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Cited by 2,262Neural and Behavioral Psychology StudiesHistorical and Modern Theater StudiesNeurological disorders and treatments

Frontal-subcortical circuits and human behavior

Cummings, J. L.·1993·Archives of Neurology
DOI 10.1001/archneur.1993.00540080076020
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Abstract

OBJECTIVE: This synthetic review was performed to demonstrate the utility of frontal-subcortical circuits in the explanation of a wide range of human behavioral disorders. DATA SOURCES: Reports of patients with degenerative disorders or focal lesions involving frontal lobe or linked subcortical structures were chosen from the English literature. Individual case reports and group investigations from peer-reviewed journals were evaluated. STUDY SELECTION: Studies were included if they described patient behavior in detail or reported pertinent neuropsy-chological findings and had compelling evidence of a disorder affecting frontal-subcortical circuits. DATA EXTRACTION: Information was used if the report from which it was taken met study selection criteria. DATA SYNTHESIS: Five parallel segregated circuits link the frontal lobe and subcortical structures. Clinical syndromes observed with frontal lobe injury are recapitulated with lesions of subcortical member structures of the circuits. Each prefrontal circuit has a signature behavioral syndrome: executive function deficits occur with lesions of the dorsolateral prefrontal circuit, disinhibition with lesions of the orbitofrontal circuit, and apathy with injury to the anterior cingulate circuit. Depression, mania, and obsessive-compulsive disorder may also be mediated by frontal-subcotical circuits. Movement disorders identify involvement of the basal ganglia component of frontal-subcortical circuits. CONCLUSIONS: Frontal-subcortical circuits mediate many aspects of human behavior.

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Crossref · 10.1001/archneur.1993.00540080076020

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  • The dorsolateral prefrontal circuit underlies executive function, including attention control and sustained organization for complex problem solving.

    “The dorsolateral prefrontal circuit underlies executive function, which includes the control of attention, as well as the sustained organization of behavior to solve complex problems (Cummings, 1993; Stuss and Alexander, 2000).”

    From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Cummings, 1993

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Authors
Cummings, J. L.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Cummings, J. L.
ORCID
Cummings, J. L.
Venue
Archives of Neurology
Publisher
American Medical Association (AMA)
Published
1993-08-01
Volume
50
Issue
8
Pages
873-880
ISSN
0003-9942 (ISSN-L)
DOI
10.1001/archneur.1993.00540080076020
OpenAlex
W2038012828
Cited by
2,262
References
68
Citations by year
2026: 16 · 2025: 25 · 2024: 38 · 2023: 40 · 2022: 33 · 2021: 50 · 2020: 60 · 2019: 53 · 2018: 66 · 2017: 58 · 2016: 57 · 2015: 71 · 2014: 82 · 2013: 88 · 2012: 86
FWCI
27.23
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
frontal-subcortical circuits, frontal lobe lesions, subcortical lesions, executive dysfunction, disinhibition, apathy, depression, mania, obsessive-compulsive disorder, basal ganglia, movement disorders, behavioral disorders, neuropsychology
MeSH terms
Behavior, Brain Diseases, Frontal Lobe, Humans, Neural Pathways

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