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Age–adjusted recurrence risks for relatives of patients with multiple sclerosis
Open accessAbstract
Familial aggregation is a cardinal epidemiological feature of multiple sclerosis, but few investigators have systematically examined recurrence risks for relatives of affected individuals in the United Kingdom. As part of a cross-sectional study of multiple sclerosis in Cambridgeshire, pedigree details were taken on 674 probands. Sex-specific, crude and age-adjusted recurrence risks were assessed amongst relatives of probands, applying a statistical model based on the observed age at onset of affected individuals and providing risks for clinical counselling. Details on year of birth, present age or age at death, and disease status were available on 11 391 relatives of successive probands. Nineteen percent of patients reported an additionally affected relative; 128 non-proband affected relatives were identified and the highest risk was observed for sisters. There was a systematic reduction in relative risk with genetic distance from the proband and no preferential recurrence for maternal or paternal relatives.
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Citations
Cited by
The natural history of multiple sclerosis:a geographically based study
Cottrell, D. A., Kremenchutzky, M., Rice, G. P. A., Koopman, W. J., Hader, W., Baskerville, J., & Ebers, G. C. (1999) · Brain · doi:10.1093/brain/122.4.625 · Cited by 1,163
Genetics of multiple sclerosis
Dyment, D. A., Ebers, G. C., & Dessa Sadovnick, A. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00663-x · Cited by 563
Multiple sclerosis: risk factors, prodromes, and potential causal pathways
Ramagopalan, S. V., Dobson, R., Meier, U. C., & Giovannoni, G. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70094-6 · Cited by 548
Sex and gender issues in multiple sclerosis
Harbo, H. F., Gold, R., & Tintoré, M. (2013) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285613488434 · Cited by 529
The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
Oksenberg, J. R., Baranzini, S. E., Sawcer, S., & Hauser, S. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2395 · Cited by 347
Metadata
- Authors
- Robertson, N. P., Fraser, M., Deans, J., Clayton, D., Walker, N., & Compston, D. A. S.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 1996
- Volume
- 119
- Issue
- 2
- Pages
- 449-455
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2128247131
- Cited by
- 234
- References
- 0
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Robertson, N. P., Fraser, M., Deans, J., Clayton, D., Walker, N., & Compston, D. A. S. (1996). Age–adjusted recurrence risks for relatives of patients with multiple sclerosis. Brain. https://doi.org/10.1093/brain/119.2.449
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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