The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine
Abstract
The way in which medication overuse transforms episodic migraine into chronic daily headache is unknown. To search for candidate brain areas involved in this process, we measured glucose metabolism with 18-FDG PET in 16 chronic migraineurs with analgesic overuse before and 3 weeks after medication withdrawal and compared the data with those of a control population (n = 68). Before withdrawal, the bilateral thalamus, orbitofrontal cortex (OFC), anterior cingulate gyrus, insula/ventral striatum and right inferior parietal lobule were hypometabolic, while the cerebellar vermis was hypermetabolic. All dysmetabolic areas recovered to almost normal glucose uptake after withdrawal of analgesics, except the OFC where a further metabolic decrease was found. A subanalysis showed that most of the orbitofrontal hypometabolism was due to eight patients overusing combination analgesics and/or an ergotamine-caffeine preparation. Medication overuse headache is thus associated with reversible metabolic changes in pain processing structures like other chronic pain disorders, but also with persistent orbitofrontal hypofunction. The latter is known to occur in drug dependence and could predispose subgroups of migraineurs to recurrent analgesic overuse.
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Cites
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Cited by
tDCS‐Induced Analgesia and Electrical Fields in Pain‐Related Neural Networks in Chronic Migraine
DaSilva, A. F., Mendonca, M. E., Zaghi, S., Lopes, M., DosSantos, M. F., Spierings, E. L., Bajwa, Z., Datta, A., Bikson, M., & Fregni, F. (2012) · Headache: The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2012.02141.x · Cited by 305
Clinical features, pathophysiology, and treatment of medication-overuse headache
Evers, S., & Marziniak, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70008-9 · Cited by 233
Katsarava, Z., & Obermann, M. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328360d596 · Cited by 55
Metadata
- Authors
- Fumal, A., Laureys, S., Di Clemente, L., Boly, M., Bohotin, V., Vandenheede, M., Coppola, G., Salmon, E., Kupers, R., & Schoenen, J.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-12-05
- Volume
- 129
- Issue
- 2
- Pages
- 543-550
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2153079669
- Cited by
- 299
- References
- 53
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fumal, A., Laureys, S., Di Clemente, L., Boly, M., Bohotin, V., Vandenheede, M., Coppola, G., Salmon, E., Kupers, R., & Schoenen, J. (2006). Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine. Brain. https://doi.org/10.1093/brain/awh691
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