The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
tDCS‐Induced Analgesia and Electrical Fields in Pain‐Related Neural Networks in Chronic Migraine
Open accessAbstract
Objective.— We investigated in a sham‐controlled trial the analgesic effects of a 4‐week treatment of transcranial direct current stimulation (tDCS) over the primary motor cortex in chronic migraine. In addition, using a high‐resolution tDCS computational model, we analyzed the current flow (electric field) through brain regions associated with pain perception and modulation. Methods.— Thirteen patients with chronic migraine were randomized to receive 10 sessions of active or sham tDCS for 20 minutes with 2 mA over 4 weeks. Data were collected during baseline, treatment and follow‐up. For the tDCS computational analysis, we adapted a high‐resolution individualized model incorporating accurate segmentation of cortical and subcortical structures of interest. Results.— There was a significant interaction term (time vs group) for the main outcome (pain intensity) and for the length of migraine episodes (ANOVA, P < .05 for both analyses). Post‐hoc analysis showed a significant improvement in the follow‐up period for the active tDCS group only. Our computational modeling studies predicted electric current flow in multiple cortical and subcortical regions associated with migraine pathophysiology. Significant electric fields were generated, not only in targeted cortical regions but also in the insula, cingulate cortex, thalamus, and brainstem regions. Conclusions.— Our findings give preliminary evidence that patients with chronic migraine have a positive, but delayed, response to anodal tDCS of the primary motor cortex. These effects may be related to electrical currents induced in pain‐related cortical and subcortical regions.
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Cites
Nitsche, M. A., & Paulus, W. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00633.x · Cited by 5,656
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Brunoni, A. R., Nitsche, M. A., Bolognini, N., Bikson, M., Wagner, T., Merabet, L., Edwards, D. J., Valero-Cabre, A., Rotenberg, A., Pascual-Leone, A., et al. (2012) · Brain stimulation · doi:10.1016/j.brs.2011.03.002 · Cited by 1,445
Self-citationBrain stem activation in spontaneous human migraine attacks
Weiller, C., May, A., Limmroth, V., Jüptner, M., Kaube, H., Schayck, R. V., Coenen, H. H., & Dlener, H. C. (1995) · Nature Medicine · doi:10.1038/nm0795-658 · Cited by 1,384
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Self-citationHypothalamic activation in cluster headache attacks
May, A., Bahra, A., Büchel, C., Frackowiak, R. S., & Goadsby, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02470-2 · Cited by 1,123
An association between migraine and cutaneous allodynia
Burstein, R., Yarnitsky, D., Goor-Aryeh, I., Ransil, B. J., & Bajwa, Z. H. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200005)47:5<614::aid-ana9>3.0.co;2-n · Cited by 1,016
Self-citationNew Appendix Criteria Open for a Broader Concept of Chronic Migraine
Olesen, J., Bousser, M.-G., Diener, H.-C., Dodick, D., First, M., Goadsby, P., Göbel, H., Lainez, M., Lance, J., Lipton, R., et al. (2006) · Cephalalgia · doi:10.1111/j.1468-2982.2006.01172.x · Cited by 909
Lang, N., Siebner, H. R., Ward, N. S., Lee, L., Nitsche, M. A., Paulus, W., Rothwell, J. C., Lemon, R. N., & Frackowiak, R. S. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04233.x · Cited by 769
Cited by
Kuo, M.-F., Paulus, W., & Nitsche, M. A. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.117 · Cited by 415
Health, T. L. G. (2020) · The Lancet Global Health · doi:10.1016/s2214-109x(20)30432-0 · Cited by 417
“16 A number of studies have reported the benefits of tDCS on chronic pain disorders(17-19) and migraines.(20) The therapy has also been noted to improve attention and concentration 22 and cognitive ability.”
Nelson, J. T., McKinley, R. A., Golob, E. J., Warm, J. S., & Parasuraman, R. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2012.11.061 · Cited by 300
Conforto, A. B., Amaro, E., Gonçalves, A. L., Mercante, J. P., Guendler, V. Z., Ferreira, J. R., Kirschner, C. C., & Peres, M. F. (2014) · Cephalalgia · doi:10.1177/0333102413515340 · Cited by 125
The effects of trauma on brain and body: A unifying role for the midbrain periaqueductal gray
Terpou, B. A., Harricharan, S., McKinnon, M. C., Frewen, P., Jetly, R., & Lanius, R. A. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24447 · Cited by 82
Metadata
- Authors
- DaSilva, A. F., Mendonca, M. E., Zaghi, S., Lopes, M., DosSantos, M. F., Spierings, E. L., Bajwa, Z., Datta, A., Bikson, M., & Fregni, F.
- Venue
- Headache: The Journal of Head and Face Pain
- Publisher
- Wiley
- Published
- 2012-04-18
- Volume
- 52
- Issue
- 8
- Pages
- 1283-1295
- ISSN
- 0017-8748 (ISSN-L)
- 1526-4610
- OpenAlex
- W2098114243
- Cited by
- 305
- References
- 65
- FWCI
- 18.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- DaSilva, A. F., Mendonca, M. E., Zaghi, S., Lopes, M., DosSantos, M. F., Spierings, E. L., Bajwa, Z., Datta, A., Bikson, M., & Fregni, F. (2012). tDCS‐Induced Analgesia and Electrical Fields in Pain‐Related Neural Networks in Chronic Migraine. Headache: The Journal of Head and Face Pain. https://doi.org/10.1111/j.1526-4610.2012.02141.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
