The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Focal cortical presentations of Alzheimer's disease
Abstract
To determine the frequency of Alzheimer's disease (AD) pathology in patients presenting with progressive focal cortical syndromes, notably posterior cortical atrophy (PCA), corticobasal syndrome (CBS), behavioural variant frontotemporal dementia (bvFTD), progressive non-fluent aphasia (PNFA) (or a mixed aphasia) and semantic dementia (SD); and to compare the age of onset, evolution and prognosis in patients with focal cortical presentations of AD versus more typical AD and those with non AD pathology. From a total of 200 patients with comprehensive prospective clinical and pathological data we selected 120 : 100 consecutive cases with focal cortical syndromes and 20 with clinically typical AD. Clinical files were reviewed blind to pathological diagnosis. Of the 100 patients with focal syndromes, 34 had AD as the primary pathological diagnosis with the following distribution across clinical subtypes: all 7 of the PCA (100%); 6 of 12 with CBS (50%); 2 of 28 with bvFTD (7.1%); 12 of 26 with PNFA (44.1%); 5 of 7 with mixed aphasia (71.4%) and 2 of 20 with SD (10%). Of 20 with clinically typical AD, 19 had pathological AD. Age at both onset and death was greater in the atypical AD cases than those with non-AD pathology, although survival was equivalent. AD is a much commoner cause of focal cortical syndromes than previously recognised, particularly in PCA, PNFA and CBS, but rarely causes SD or bvFTD. The focal syndrome may remain pure for many years. Patients with atypical AD tend…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“While not apparent in our cases, studies have demonstrated that executive or behavioral dysfunction typically develop after memory deficits in fvAD [1, 22, 23].”
From Diagnosing the frontal variant of Alzheimer’s disease: a clinician’s yellow brick road (2017) · cites this paper as [1]
In the citing paper
“Some studies have suggested that fvAD accounts for approximately 2–3% of AD, [1, 2]”
From Diagnosing the frontal variant of Alzheimer’s disease: a clinician’s yellow brick road (2017) · cites this paper as [1]
In the citing paper
“Conversely, in fvAD memory impairment is the first abnormality in up to 85% of patients (Fig. 4), with the remainder developing memory impairment within 3 years from symptom onset [1, 22, 23].”
From Diagnosing the frontal variant of Alzheimer’s disease: a clinician’s yellow brick road (2017) · cites this paper as [1]
Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Mild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980
Petersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L., & DeKosky, S. T. (2001) · Neurology · doi:10.1212/wnl.56.9.1133 · Cited by 2,065
Pathologic heterogeneity in clinically diagnosed corticobasal degeneration
Boeve, B. F., Maraganore, D. M., Parisi, J. E., Ahlskog, J. E., Graff-Radford, N., Caselli, R. J., Dickson, D. W., Kokmen, E., & Petersen, R. C. (1999) · Neurology · doi:10.1212/wnl.53.4.795 · Cited by 417
Clark, C. M., Xie, S., Chittams, J., Ewbank, D., Peskind, E., Galasko, D., Morris, J. C., McKeel, D. W., Farlow, M., Weitlauf, S. L., et al. (2003) · Archives of Neurology · doi:10.1001/archneur.60.12.1696 · Cited by 357
Greene, J. D. W., Baddeley, A. D., & Hodges, J. R. (1996) · Neuropsychologia · doi:10.1016/0028-3932(95)00151-4 · Cited by 277
Self-citationHof, P. R., Vogt, B. A., Bouras, C., & Morrison, J. H. (1997) · Vision Research · doi:10.1016/s0042-6989(96)00240-4 · Cited by 246
Neural substrates of cognitive and behavioral deficits in atypical Alzheimer's disease
von Gunten, A., Bouras, C., Kövari, E., Giannakopoulos, P., & Hof, P. R. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.11.003 · Cited by 75
Flagged first, then by citations
Cited by
Sorted by citations
Items 501–523 of 523
La dégénérescence cortico-basale : une tauopathie qui est bien plus qu’une pathologie du mouvement
Sellal, F., Lannes, B., & Mohr, M. (2015) · Pratique Neurologique - FMC · doi:10.1016/j.praneu.2014.12.004
Corlier, F. W. (2014) · theses.fr (ABES) · doi:10.70675/c68b852dz827az4d11z94a4z004c68a07153
“Les études neuropathologiques suggèrent que ces différentes formes cliniques de la MA sont associées à un motif de distribution corticale des DNF, différent de celui de la MA typique, avec une relative préservation des structures limbiques (Murray et al., 2011; Whitwell et al., 2012).”
InfluentialInvited commentary on "Structural and functional imaging in parkinsonian syndromes".
Bohnen, N., & Frey, K. (2014) · Radiographics · doi:10.1148/rg.345140192
Visuospatial Deficit and Apraxia in Posterior Cortical Atrophy (PCA): a Single Case Follow-up Study
D’Anna, L. (2014) · Journal of Neurological Disorders · doi:10.4172/2329-6895.1000166 · Cited by 1
“Morevover, it is well established that the most frequent focal cortical presentations af AD are PCA, corticobasal syndrome (CBS), behavioural variant frontotemporal dementia (bvFTD), progressive non-fluent aphasia (PNFA) (or a mixed aphasia) and semantic dementia (SD) [7].”
BackgroundDiagnosticare la malattia di Alzheimer
Sarazin, M., Hamelin, L., Lamari, F., & Bottlaender, M. (2014) · EMC - Neurologia · doi:10.1016/s1634-7072(14)67223-8
Diagnostiquer la maladie d’Alzheimer
Sarazin, M., Hamelin, L., Lamari, F., & Bottlaender, M. (2013) · EMC - Neurologia · doi:10.1016/s0246-0378(13)59696-5
Habert, M., & Kas, A. (2013) · EMC - Neurologia · doi:10.1016/s0246-0378(13)52780-1
アルツハイマー病と semantic dementia の意味記憶障害
吉野, 文., 船山, 道., 是木, 明., 斎藤, 文., 江口, 洋., 三村, 將., 吉野, 相., & 加藤, 元. (2012) · doi:10.2496/hbfr.32.405
Krolak‐Salmon, P., & Vighetto, A. (2012) · Future Neurology · doi:10.2217/fnl.12.39
“(2012) 7(4) 404 future science group [4,13–17].”
BackgroundDiagnosis of Alzheimer’s disease
Rosa‐Neto, P., Rowley, J., Leuzy, A., Mohades, S., Shin, M., Dauar, M. T., & Gauthier, S. G. (2012) · doi:10.2217/ebo.12.66
Nosologie des dégénérescences lobaires frontotemporales
Hannequin, D., Wallon, D., Martinaud, O., Maltête, D., Deramecourt, V., Campion, D., & Ber, I. L. (2011) · Pratique Neurologique - FMC · doi:10.1016/j.praneu.2011.02.009
Macías, E., González, A., Rangel, A., & Néciga, E. G. (2011) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/s0304-5412(11)70068-3
POSTERIOR CORTICAL ATROPHY: A CASE REPORT
Milošević, V., Dačković, J., Ocić, G., Ilic, V., & Salak, B. (2009) · Praxis Medica · doi:10.70949/pramed200902315m
Vemuri, P., Murray, M. E., & Jack, C. R. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410529-4.00010-3
Neuro-ophthalmology in the Geriatric Eye
Tabba, S., Yeh, Y.-H. R., Kini, T. A., Othman, B. A. A., & Lee, A. G. (2020) · touchREVIEWS in Ophthalmology · doi:10.17925/usor.2020.13.1.30
Amyloid-β PET Imaging in Aging and Dementia
Tolboom, N., Ossenkoppele, R., & van Berckel, B. N. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-01523-7_11
Major or Mild Frontotemporal Neurocognitive Disorder
Hategan, A., Bourgeois, J. A., & Hirsch, C. H. (2017) · Springer eBooks · doi:10.1007/978-3-319-67555-8_19
Diagnosis (1): Cognitive Syndromes, Comorbidities, No Diagnosis, and Wrong Diagnosis
Larner, A. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-75259-4_8 · Cited by 1
Multiple Sclerosis Presenting as Posterior Cortical Atrophy
Nathalie, E., Nia, C., Jean, V., Tony, G., & Serge, B. (2017) · doi:10.21767/2472-5048.100034
“More rarely, PCA may be associated to other neurodegenerative etiologies, such as corticobasal degeneration, dementia with Lewy bodies, prion disease (Creutzfeldt-Jakob disease), and subcortical gliosis [1,3-5].”
BackgroundGenetics of Atypical Parkinsonism
Stamelou, M., & Bhatia, K. P. (2015) · Springer eBooks · doi:10.1007/978-3-319-17223-1_3
Diagnosis (1): Cognitive Syndromes, Comorbidities, and No Diagnosis
Larner, A. J. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6371-8_7
Attention Disorders in Neurodegenerative Conditions
Bartolomeo, P. (2013) · Springer eBooks · doi:10.1007/978-1-4471-5649-9_8
Metadata
- Authors
- Alladi, S., Xuereb, J., Bak, T., Nestor, P., Knibb, J., Patterson, K., & Hodges, J. R.
- Affiliations
- MRC Cognition and Brain Sciences Unit (GB)
- Corresponding author
- Alladi, S.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-10-01
- Volume
- 130
- Issue
- 10
- Pages
- 2636-2645
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2142244150
- Cited by
- 581
- References
- 0
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 16 · 2023: 17 · 2022: 23 · 2021: 21 · 2020: 37 · 2019: 28 · 2018: 28 · 2017: 30 · 2016: 20 · 2015: 44 · 2014: 45 · 2013: 47 · 2012: 50
- FWCI
- 15.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- Alzheimer's disease, posterior cortical atrophy, corticobasal syndrome, behavioral variant frontotemporal dementia, progressive nonfluent aphasia, semantic dementia, mixed aphasia, age of onset, prognosis, survival, neuropathology
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Cerebral Cortex, Cognition Disorders, Dementia, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Prognosis, Syndrome, Survival Analysis, Age of Onset, Disease Progression, Aphasia, Primary Progressive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
