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Cited by 278Dementia and Cognitive Impairment ResearchMemory Processes and InfluencesCognitive Functions and Memory

Analysis of the episodic memory deficit in early Alzheimer's disease: Evidence from the doors and people test

Greene, John D.W., Baddeley, Alan D., Hodges, John R.·1996·Neuropsychologia
DOI 10.1016/0028-3932(95)00151-4
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Abstract

Anterograde episodic memory was assessed in a cohort of 33 patients with early dementia of Alzheimer type (DAT) and 30 matched controls using immediate and delayed prose recall, the CERAD word learning test and the recently developed doors and people test of visual and verbal recall and recognition. DAT patients showed markedly impaired learning on all three measures, with little evidence of cumulation of information across trials. Patients showed more forgetting than controls on prose recall and the CERAD word list, but more detailed analysis suggested that this differential loss was attributable to the contribution of primary memory to immediate but not delayed recall. No differences in forgetting rate were observed on the doors and people test. Scaled scores were used to derive a recall-recognition index, together with a measure of material-specific memory based on the ratio of verbal to visual memory deficits. There was no evidence for differential sensitivity of recall over recognition, implying that the episodic memory deficit is one of learning, rather than of the retrieval of learned material. Although individuals varied in the relative degree of impairment of verbal and visual memory, there was no general tendency for material-specificity. It was concluded that the episodic memory deficit in DAT is general in nature and primarily reflects impaired learning rather than accelerated forgetting or disrupted retrieval.

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  • The memory deficit in this murine model mimics early-stage Alzheimer's disease patients who are unable to store newly acquired information but preserve old memories.

    “This suggests that the memory deficit in our murine model mimics the situation in early-stage AD patients who are unable to store newly acquired information but preserve old memories (22).”

    From Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein (2010) · cites this paper as [22]

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Authors
Greene, J. D. W., Baddeley, A. D., & Hodges, J. R.
Affiliations
University of Cambridge (GB)
Corresponding author
Hodges, John R.
ORCID
Baddeley, Alan D.
Venue
Neuropsychologia
Publisher
Elsevier BV
Published
1996-06
Volume
34
Issue
6
Pages
537-551
ISSN
0028-3932 (ISSN-L)
DOI
10.1016/0028-3932(95)00151-4
OpenAlex
W1999825136
Cited by
277
References
81
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 21 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 9 · 2016: 8 · 2015: 12 · 2014: 17 · 2013: 11 · 2012: 14
FWCI
3.87
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuropsychologia (publishedVersion)
  • PubMed (publishedVersion)
  • Bristol Research (University of Bristol) (submittedVersion)
Funders
Medical Research Council
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
episodic memory, early Alzheimer's disease, anterograde amnesia, verbal learning, visual memory, forgetting, primary memory, prose recall
MeSH terms
Aged, Alzheimer Disease, Cognition, Female, Humans, Learning, Male, Memory Disorders, Neuropsychological Tests, Mental Recall

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