Cited by 148Action Observation and SynchronizationEmpathy and Medical EducationNeural and Behavioral Psychology Studies

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Acute lesions that impair affective empathy

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Leigh, Richard, Oishi, Kenichi, Hsu, John, Lindquist, Martin, Gottesman, Rebecca F., Jarso, Samson, Crainiceanu, Ciprian, Mori, Susumu, Hillis, Argye E.·2013·Brain

DOI 10.1093/brain/awt177PMC PMC3722353

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Abstract

Functional imaging studies of healthy participants and previous lesion studies have provided evidence that empathy involves dissociable cognitive functions that rely on at least partially distinct neural networks that can be individually impaired by brain damage. These studies converge in support of the proposal that affective empathy--making inferences about how another person feels--engages at least the following areas: prefrontal cortex, orbitofrontal gyrus, anterior insula, anterior cingulate cortex, temporal pole, amygdala and temporoparietal junction. We hypothesized that right-sided lesions to any one of these structures, except temporoparietal junction, would cause impaired affective empathy (whereas bilateral damage to temporoparietal junction would be required to disrupt empathy). We studied 27 patients with acute right hemisphere ischaemic stroke and 24 neurologically intact inpatients on a test of affective empathy. Acute impairment of affective empathy was associated with infarcts in the hypothesized network, particularly temporal pole and anterior insula. All patients with impaired affective empathy were also impaired in comprehension of affective prosody, but many patients with impairments in prosodic comprehension had spared affective empathy. Patients with impaired affective empathy were older, but showed no difference in performance on tests of hemispatial neglect, volume of infarct or sex distribution compared with patients with intact affective empathy.

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Authors: Leigh, R., Oishi, K., Hsu, J., Lindquist, M., Gottesman, R. F., Jarso, S., Crainiceanu, C., Mori, S., & Hillis, A. E.
Affiliations: Johns Hopkins University (US)
ORCID: Leigh, Richard
Oishi, Kenichi
Lindquist, Martin
Gottesman, Rebecca F.
Crainiceanu, Ciprian
Mori, Susumu
Hillis, Argye E.
Venue: Brain
Publisher: Oxford University Press (OUP)
Published: 2013-07-03
Volume: 136
Issue: 8
Pages: 2539-2549
ISSN: 0006-8950 (ISSN-L)
1460-2156
DOI: 10.1093/brain/awt177
PMC: PMC3722353
OpenAlex: W2170090072
Cited by: 148
References: 60
Citations by year: 2026: 4 · 2025: 9 · 2024: 10 · 2023: 8 · 2022: 15 · 2021: 12 · 2020: 12 · 2019: 16 · 2018: 18 · 2017: 9 · 2016: 10 · 2015: 13 · 2014: 10 · 2013: 2
FWCI: 17.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Brain (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01 NS47691, R01NS047691)
National Institute of Biomedical Imaging and Bioengineering (P41EB015909)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD065955)
Topics: Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
Health Sciences › Medicine › Psychiatry and Mental health › Empathy and Medical Education
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: affective empathy, acute stroke, right hemisphere infarction, temporal pole, anterior insula, temporoparietal junction, hemispatial neglect
MeSH terms: Adult, Aged, Brain, Brain Mapping, Brain Ischemia, Cognition, Emotions, Empathy, Female, Humans, Functional Laterality, Male, Middle Aged, Nerve Net, Social Perception, Stroke

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Acute lesions that impair affective empathy

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