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Acute lesions that impair affective empathy
Open accessAbstract
Functional imaging studies of healthy participants and previous lesion studies have provided evidence that empathy involves dissociable cognitive functions that rely on at least partially distinct neural networks that can be individually impaired by brain damage. These studies converge in support of the proposal that affective empathy--making inferences about how another person feels--engages at least the following areas: prefrontal cortex, orbitofrontal gyrus, anterior insula, anterior cingulate cortex, temporal pole, amygdala and temporoparietal junction. We hypothesized that right-sided lesions to any one of these structures, except temporoparietal junction, would cause impaired affective empathy (whereas bilateral damage to temporoparietal junction would be required to disrupt empathy). We studied 27 patients with acute right hemisphere ischaemic stroke and 24 neurologically intact inpatients on a test of affective empathy. Acute impairment of affective empathy was associated with infarcts in the hypothesized network, particularly temporal pole and anterior insula. All patients with impaired affective empathy were also impaired in comprehension of affective prosody, but many patients with impairments in prosodic comprehension had spared affective empathy. Patients with impaired affective empathy were older, but showed no difference in performance on tests of hemispatial neglect, volume of infarct or sex distribution compared with patients with intact affective empathy.
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“emotion recognition and empathic deficits occur after insular cortex lesions3–5”
From Insular cortex mediates approach and avoidance responses to social affective stimuli (2018) · cites this paper as [5]
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“the amygdala contributing to the emotional component of empathy (Cox et al., 2012; Leigh et al., 2013).”
From Oxytocin Enhancement of Emotional Empathy: Generalization Across Cultures and Effects on Amygdala Activity (2018) · cites this paper as Leigh et al., 2013
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Metadata
- Authors
- Leigh, R., Oishi, K., Hsu, J., Lindquist, M., Gottesman, R. F., Jarso, S., Crainiceanu, C., Mori, S., & Hillis, A. E.
- Affiliations
- Johns Hopkins University (US)
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-07-03
- Volume
- 136
- Issue
- 8
- Pages
- 2539-2549
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC3722353
- OpenAlex
- W2170090072
- Cited by
- 148
- References
- 60
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 10 · 2023: 8 · 2022: 15 · 2021: 12 · 2020: 12 · 2019: 16 · 2018: 18 · 2017: 9 · 2016: 10 · 2015: 13 · 2014: 10 · 2013: 2
- FWCI
- 17.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01 NS47691, R01NS047691)
- National Institute of Biomedical Imaging and Bioengineering (P41EB015909)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD065955)
- Topics
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Health Sciences › Medicine › Psychiatry and Mental health › Empathy and Medical Education
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- affective empathy, acute stroke, right hemisphere infarction, temporal pole, anterior insula, temporoparietal junction, hemispatial neglect
- MeSH terms
- Adult, Aged, Brain, Brain Mapping, Brain Ischemia, Cognition, Emotions, Empathy, Female, Humans, Functional Laterality, Male, Middle Aged, Nerve Net, Social Perception, Stroke
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