The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Autism: reduced connectivity between cortical areas involved in face expression, theory of mind, and the sense of self
Open accessAbstract
Whole-brain voxel-based unbiased resting state functional connectivity was analysed in 418 subjects with autism and 509 matched typically developing individuals. We identified a key system in the middle temporal gyrus/superior temporal sulcus region that has reduced cortical functional connectivity (and increased with the medial thalamus), which is implicated in face expression processing involved in social behaviour. This system has reduced functional connectivity with the ventromedial prefrontal cortex, which is implicated in emotion and social communication. The middle temporal gyrus system is also implicated in theory of mind processing. We also identified in autism a second key system in the precuneus/superior parietal lobule region with reduced functional connectivity, which is implicated in spatial functions including of oneself, and of the spatial environment. It is proposed that these two types of functionality, face expression-related, and of one’s self and the environment, are important components of the computations involved in theory of mind, whether of oneself or of others, and that reduced connectivity within and between these regions may make a major contribution to the symptoms of autism. Cheng, Rolls et al. examine whole-brain voxel-based resting-state functional connectivity in 418 people with autism. They reveal reduced connectivity between regions involved in facial expression processing and theory of mind (middle temporal gyrus), emotion processing (ventromedial prefrontal cortex), and the representation of self (precuneus and related posterior cingulate areas).
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Cites
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Methods to detect, characterize, and remove motion artifact in resting state fMRI
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Cited by
Resting-state functional connectivity in autism spectrum disorders: a review
Hull, J. V., Dokovna, L. B., Jacokes, Z. J., Torgerson, C. M., Irimia, A., & Van Horn, J. D. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00205 · Cited by 546
The Default Mode Network in Autism
Padmanabhan, A., Lynch, C. J., Schaer, M., & Menon, V. (2017) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.04.004 · Cited by 375
Cheng, W., Rolls, E. T., Qiu, J., Liu, W., Tang, Y., Huang, C.-C., Wang, X., Zhang, J., Lin, W., Zheng, L., et al. (2016) · Brain · doi:10.1093/brain/aww255 · Cited by 294
Self-citationThe functional role of the precuneus
Dadario, N. B., & Sughrue, M. E. (2023) · Brain · doi:10.1093/brain/awad181 · Cited by 319
Alaerts, K., Swinnen, S. P., & Wenderoth, N. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw027 · Cited by 193
Metadata
- Authors
- Cheng, W., Rolls, E. T., Gu, H., Zhang, J., & Feng, J.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-03-20
- Volume
- 138
- Issue
- 5
- Pages
- 1382-1393
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2104482304
- Cited by
- 263
- References
- 49
- FWCI
- 16.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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