The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Iron and dopamine: a toxic couple
Abstract
Iron accumulation is a cardinal feature of degenerating regions in the Parkinson's disease brain. As a potent pro-oxidant, redox-active iron may be a key player in upstream mechanisms that precipitate cell death in this disorder. Although an elevation in brain iron levels is a normal feature of ageing, the increase is greater in Parkinson's disease; on the other hand, the effects of the disease are most marked in the nigrostriatal dopaminergic system. In this Update, we explain that neurodegeneration in the affected regions may result from the potent redox couple formed by iron and dopamine itself, and discuss the clinical implications of this molecular trait in this dynamic and rapidly moving area of Parkinson's disease research.
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Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
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Oxidative stress in neurodegeneration: Cause or consequence?
Andersen, J. K. (2004) · Nature Medicine · doi:10.1038/nrn1434 · Cited by 1,869
The role of iron in brain ageing and neurodegenerative disorders
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Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
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Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease
Kordower, J. H., Olanow, C. W., Dodiya, H. B., Chu, Y., Beach, T. G., Adler, C. H., Halliday, G. M., & Bartus, R. T. (2013) · Brain · doi:10.1093/brain/awt192 · Cited by 1,286
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Cited by
Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease
Trist, B. G., Hare, D. J., & Double, K. L. (2019) · Aging Cell · doi:10.1111/acel.13031 · Cited by 778
Self-citationDopamine promotes cellular iron accumulation and oxidative stress responses in macrophages
Dichtl, S., Haschka, D., Nairz, M., Seifert, M., Volani, C., Lutz, O., & Weiss, G. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.12.001 · Cited by 76
Reichelt, A. C., Gibson, G. D., Abbott, K. N., & Hare, D. J. (2019) · Food & Function · doi:10.1039/c8fo02118j · Cited by 65
Self-citationIron Redox Chemistry and Implications in the Parkinson’s Disease Brain
Abeyawardhane, D. L., & Lucas, H. R. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4609702 · Cited by 35
Discovery of a Gut Bacterial Metabolic Pathway that Drives α-Synuclein Aggregation
Ortiz de Ora, L., Balsamo, J. M., Uyeda, K. S., & Bess, E. N. (2024) · ACS Chemical Biology · doi:10.1021/acschembio.4c00095 · Cited by 24
Metadata
- Authors
- Hare, D. J., & Double, K. L.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-03-08
- Volume
- 139
- Issue
- 4
- Pages
- 1026-1035
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2294172555
- Cited by
- 283
- References
- 109
- FWCI
- 19.52
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
