A high-fat high-sugar diet in adolescent rats impairs social memory and alters chemical markers characteristic of atypical neuroplasticity and parvalbumin interneuron depletion in the medial prefrontal cortex
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Abstract
A hypercaloric diet given to adolescent rats induces social memory deficits and reduced neurochemical markers of normal social development.
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Social recognition memory is probably consolidated through activation of CREB-mediated gene expression in the hippocampus, mPFC, anterior cingulate cortex, and amygdala.
“Social recognition memory is probably consolidated through the activation of cAMP response element-binding protein (CREB)-mediated gene expression in the hippocampus, mPFC, anterior cingulate cortex, and amygdala [123, 124].”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [124]
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The extracellular matrix and perineuronal nets in memory
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- Authors
- Reichelt, A. C., Gibson, G. D., Abbott, K. N., & Hare, D. J.
- Affiliations
- Western University (CA)
- UNSW Sydney (AU)
- The University of Melbourne (AU)
- Corresponding author
- Reichelt, Amy C.
- Hare, Dominic J.
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 10
- Issue
- 4
- Pages
- 1985-1998
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W2922808732
- Cited by
- 65
- References
- 21
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 12 · 2023: 7 · 2022: 7 · 2021: 12 · 2020: 11 · 2019: 2
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- rsc.li/journals-terms-of-use (am, 444 d)
- Locations
- Food & Function (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- UTS ePRESS (University of Technology Sydney) (submittedVersion)
- Funders
- Australian Research Council (DE140101071, DP180101974)
- National Health and Medical Research Council (GNT1122981)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- high-fat high-sugar diet, adolescent diet, social recognition memory, perineuronal nets, parvalbumin interneurons, medial prefrontal cortex, infralimbic cortex, ΔFosB, neuroplasticity, obesity, GABAergic interneurons
- MeSH terms
- Dietary Sugars, Animals, Humans, Interneurons, Memory, Neuronal Plasticity, Parvalbumins, Social Behavior, Rats, Sprague-Dawley, Prefrontal Cortex, Rats, Diet, High-Fat, GABAergic Neurons, Pediatric Obesity
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