Cited by 127Epilepsy research and treatmentNeuroscience and Neuropharmacology ResearchPharmacological Effects and Toxicity Studies

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau.

Abstract

There are no treatments in clinical practice known to mitigate the neurobiological processes that convert a healthy brain into an epileptic one, a phenomenon known as epileptogenesis. Downregulation of protein phosphatase 2A, a protein that causes the hyperphosphorylation of tau, is implicated in neurodegenerative diseases commonly associated with epilepsy, such as Alzheimer's disease and traumatic brain injury. Here we used the protein phosphatase 2A activator sodium selenate to investigate the role of protein phosphatase 2A in three different rat models of epileptogenesis: amygdala kindling, post-kainic acid status epilepticus, and post-traumatic epilepsy. Protein phosphatase 2A activity was decreased, and tau phosphorylation increased, in epileptogenic brain regions in all three models. Continuous sodium selenate treatment mitigated epileptogenesis and prevented the biochemical abnormalities, effects which persisted after drug withdrawal. Our studies indicate that limbic epileptogenesis is associated with downregulation of protein phosphatase 2A and the hyperphosphorylation of tau, and that targeting this mechanism with sodium selenate is a potential anti-epileptogenic therapy.

Overview

Integrity signals

Registry

Crossref · 10.1093/brain/aww116

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 57 references

Research works printed but not linked: 2

  1. Abramoff, 2004, Image processing with Image J, Biophoton Int, 11, 36
  2. 10.1042/bj3530417 · DOI

Cited by

Sorted by citations

Metadata

Authors
Liu, S.-J., Zheng, P., Wright, D. K., Dezsi, G., Braine, E., Nguyen, T., Corcoran, N. M., Johnston, L. A., Hovens, C. M., Mayo, J. N., Hudson, M., Shultz, S. R., Jones, N. C., & O’Brien, T. J.
Affiliations
  • The Royal Melbourne Hospital (AU)
  • The University of Melbourne (AU)
Venue
Brain
Published
2016-06-11
Volume
139
Issue
7
Pages
1919-1938
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
OpenAlex
W2412978786
Cited by
127
References
57
Citations by year
2026: 6 · 2025: 10 · 2024: 13 · 2023: 14 · 2022: 12 · 2021: 18 · 2020: 11 · 2019: 20 · 2018: 11 · 2017: 11 · 2016: 1
FWCI
12.74
Type
journal article
Language
en
Open access
closed
Locations
  • Brain (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Keywords
sodium selenate, epileptogenesis, protein phosphatase 2A, tau hyperphosphorylation, acquired epilepsy, amygdala kindling, status epilepticus, post-traumatic epilepsy, limbic epilepsy, drug withdrawal
MeSH terms
Brain Injuries, Traumatic, Animals, Anticonvulsants, Brain, Disease Models, Animal, Electroencephalography, Epilepsy, Kainic Acid, Kindling, Neurologic, Magnetic Resonance Imaging, Male, Phosphorylation, tau Proteins, Rats, Wistar, Excitatory Amino Acid Agonists, Rats, Protein Phosphatase 2, Selenic Acid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review