Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy.
Open accessAbstract
Temporal lobe epilepsy represents a major cause of drug-resistant epilepsy. Cognitive impairment is a frequent comorbidity, but the mechanisms are not fully elucidated. We hypothesized that the cognitive impairment in drug-resistant temporal lobe epilepsy could be due to perturbations of amyloid and tau signalling pathways related to activation of stress kinases, similar to those observed in Alzheimer’s disease. We examined these pathways, as well as amyloid-β and tau pathologies in the hippocampus and temporal lobe cortex of drug-resistant temporal lobe epilepsy patients who underwent temporal lobe resection (n = 19), in comparison with age- and region-matched samples from neurologically normal autopsy cases (n = 22). Post-mortem temporal cortex samples from Alzheimer’s disease patients (n = 9) were used as positive controls to validate many of the neurodegeneration-related antibodies. Western blot and immunohistochemical analysis of tissue from temporal lobe epilepsy cases revealed increased phosphorylation of full-length amyloid precursor protein and its associated neurotoxic cleavage product amyloid-β*56. Pathological phosphorylation of two distinct tau species was also increased in both regions, but increases in amyloid-β1-42 peptide, the main component of amyloid plaques, were restricted to the hippocampus. Furthermore, several major stress kinases involved in the development of Alzheimer’s disease pathology were significantly activated in temporal lobe epilepsy brain samples, including the c-Jun N-terminal kinase and the protein kinase R-like endoplasmic reticulum kinase. In temporal lobe epilepsy cases, hippocampal levels of phosphorylated amyloid precursor protein, its pro-amyloidogenic processing enzyme beta-site amyloid precursor protein cleaving enzyme 1, and both total and hyperphosphorylated tau expression, correlated with impaired preoperative executive function. Our study suggests that neurodegenerative and stress-related processes common to those observed in Alzheimer’s disease may contribute to cognitive impairment in drug-resistant temporal lobe epilepsy. In particular, we identified several stress pathways that may represent potential novel therapeutic targets.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The presence of tau pathology in childhood or adolescent-onset epilepsies and in relatively younger temporal lobe epilepsy patient cohorts suggests a causal link between seizure activity and p-tau accumulation.
“However, the presence of tau pathology in childhood or adolescent-onset epilepsies, such as Dravet syndrome, Nodding syndrome, Lafora disease, NPC, TSC, and ASD, and in relatively younger TLE patient cohorts (Puvenna et al., 2016; Smith et al., 2019; Gourmaud et al., 2020) suggest a causal link between seizure activity and p-tau accumulation.”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Gourmaud et al., 2020
Increased total and p-tau levels measured in surgically resected tissue from temporal lobe epilepsy patients are inversely correlated with cognitive scores.
“and increased total and p-tau levels measured in surgically resected tissue from TLE patients are inversely correlated with cognitive scores (Kandratavicius et al., 2013; Tai et al., 2016; Gourmaud et al., 2020).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Gourmaud et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., & Ashe, K. H. (2006) · Nature · doi:10.1038/nature04533 · Cited by 2,769 · cited 1× · see citing works
“The amyloidogenic APP cleavage product amyloid-b 56 accumulates before amyloid-b42 dimers and is associated with memory impairment (Lesne et al., 2006).”
BackgroundRetractedAmar, F., Sherman, M. A., Rush, T., Larson, M. E., Boyle, G. E., Liu, C., Götz, J., Buisson, A., & Lesné, S. (2017) · Science Signaling · doi:10.1126/scisignal.aal2021 · Cited by 109 · see citing works
RetractedMcKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657 · see citing works
Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172 · see citing works
Alzheimer Disease Genetics Consortium (ADGC), Kunkle, B. W., The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, P. A. E. R. F. A. D. C. (., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0358-2 · Cited by 2,946 · see citing works
Amyloid Precursor Protein Processing and Alzheimer's Disease
O'Brien, R. J., & Wong, P. C. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113613 · Cited by 2,061 · see citing works
Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works
Blümcke, I., Thom, M., Aronica, E., Armstrong, D. D., Vinters, H. V., Palmini, A., Jacques, T. S., AVANZINI, G., Barkovich, A. J., Battaglia, G. S., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02777.x · Cited by 1,746 · see citing works
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
Cleary, J. P., Walsh, D. M., Hofmeister, J. J., Shankar, G. M., Kuskowski, M. A., Selkoe, D. J., & Ashe, K. H. (2004) · Nature Neuroscience · doi:10.1038/nn1372 · Cited by 1,677 · see citing works
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653 · see citing works
The distribution of tau in the mammalian central nervous system.
Binder, L. I., Frankfurter, A., & Rebhun, L. I. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.4.1371 · Cited by 1,588 · see citing works
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
Patrick, G. N., Zukerberg, L. R., Nikolić, M., de la Monte, S. M., Dikkes, P., & Tsai, L. (1999) · Nature · doi:10.1038/45159 · Cited by 1,541 · see citing works
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
Ip, Y. T., & Davis, R. J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80143-9 · Cited by 1,538 · see citing works
Tau pathology in Alzheimer disease and other tauopathies
Iqbal, K., del C. Alonso, A., Chen, S., Chohan, M. O., El-Akkad, E., Gong, C.-X., Khatoon, S., Li, B., Liu, F., Rahman, A., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.008 · Cited by 1,037 · see citing works
Blümcke, I., Thom, M., Aronica, E., Armstrong, D. D., Bartoloméi, F., Bernasconi, A., Bernasconi, N., Bien, C. G., Cendes, F., Coras, R., et al. (2013) · Epilepsia · doi:10.1111/epi.12220 · Cited by 1,010 · see citing works
Augustinack, J. C., Schneider, A., Mandelkow, E.-M., & Hyman, B. T. (2002) · Acta Neuropathologica · doi:10.1007/s004010100423 · Cited by 998 · see citing works
Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery
Blümcke, I., Spreafico, R., Haaker, G., Coras, R., Kobow, K., Bien, C. G., Pfäfflin, M., Elger, C. E., Widman, G., Schramm, J., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1703784 · Cited by 935 · see citing works
Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
Caccamo, A., Majumder, S., Richardson, A., Strong, R., & Oddo, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100420 · Cited by 881 · see citing works
Alzheimer's disease drug development pipeline: 2018
Cummings, J., Lee, G., Ritter, A., & Zhong, K. (2018) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.03.009 · Cited by 697 · see citing works
Epilepsy and Cognitive Impairments in Alzheimer Disease
Palop, J. J. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.15 · Cited by 684 · see citing works
Moechars, D., Dewachter, I., Lorent, K., Reversé, D., Baekelandt, V., Naidu, A., Tesseur, I., Spittaels, K., Haute, C. V. D., Checler, F., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6483 · Cited by 668 · see citing works
Roberson, E. D., Halabisky, B., Yoo, J. W., Yao, J., Chin, J., Yan, F., Wu, T., Hamto, P., Devidze, N., Yu, G.-Q., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4152-10.2011 · Cited by 654 · see citing works
Sustained translational repression by eIF2α-P mediates prion neurodegeneration
Moreno, J. A., Radford, H. E., Peretti, D., Steinert, J. R., Verity, N., Martin, M. G., Halliday, M., Morgan, J., Dinsdale, D. D., Ortori, C. A., et al. (2012) · Nature · doi:10.1038/nature11058 · Cited by 616 · see citing works
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation
Chen, J., Martin, B. L., & Brautigan, D. L. (1992) · Science · doi:10.1126/science.1325671 · Cited by 601 · see citing works
Epileptic activity in Alzheimer’s disease: Causes and clinical relevance
Vossel, K. A., Tartaglia, M. C., Nygaard, H. B., Zeman, A. Z., & Miller, B. L. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30044-3 · Cited by 590 · see citing works
Incidence and impact of subclinical epileptiform activity in Alzheimer’s disease.
Vossel, K. A., Ranasinghe, K. G., Beagle, A. J., Mizuiri, D., Honma, S. M., Dowling, A. F., Darwish, S. M., Van Berlo, V., Barnes, D. E., Mantle, M., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24794 · Cited by 557 · see citing works
Wang, J., Xia, Y., Grundke, I., & Iqbal, K. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129031 · Cited by 530 · see citing works
A Review of the Epidemiology of Temporal Lobe Epilepsy
Téllez‐Zenteno, J. F., & Hernández‐Ronquillo, L. (2011) · Epilepsy Research and Treatment · doi:10.1155/2012/630853 · Cited by 526 · see citing works
Zeng, L., Rensing, N. R., & Wong, M. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0066-09.2009 · Cited by 526 · see citing works
APP processing is regulated by cytoplasmic phosphorylation
Lee, M.-S., Kao, S.-C., Lemere, C. A., Xia, W., Tseng, H.-C., Zhou, Y., Neve, R. L., Ahlijanian, M. K., & Tsai, L. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200301115 · Cited by 457 · see citing works
O’Connor, T., Sadleir, K. R., Maus, E., Velliquette, R. A., Zhao, J., Cole, S. L., Eimer, W. A., Hitt, B. D., Bembinster, L. A., Lammich, S., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.047 · Cited by 422 · see citing works
Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease
Lam, A. D., Deck, G. M., Goldman, A. M., Eskandar, E. N., Noebels, J. L., & Cole, A. J. (2017) · Nature Medicine · doi:10.1038/nm.4330 · Cited by 369 · see citing works
Bhat, R. V., Shanley, J. R., Correll, M. P., Fieles, W. E., Keith, R. A., Scott, C. W., & Lee, C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190297597 · Cited by 367 · see citing works
Caccamo, A., Magrì, A., Medina, D. X., Wisely, E. V., López‐Aranda, M. F., Silva, A. J., & Oddo, S. (2013) · Aging Cell · doi:10.1111/acel.12057 · Cited by 362 · see citing works
Interictal epileptiform discharges induce hippocampal–cortical coupling in temporal lobe epilepsy
Gelinas, J. N., Khodagholy, D., Thesen, T., Devinsky, O., & Buzsáki, G. (2016) · Nature Medicine · doi:10.1038/nm.4084 · Cited by 329 · see citing works
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
Appenzeller‐Herzog, C., & Hall, M. N. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.02.006 · Cited by 316 · see citing works
Antisense Reduction of Tau in Adult Mice Protects against Seizures
DeVos, S. L., Goncharoff, D. K., Chen, G., Kebodeaux, C. S., Yamada, K., Stewart, F. R., Schuler, D. R., Maloney, S. E., Wozniak, D. F., Rigo, F., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2107-13.2013 · Cited by 311 · see citing works
Cognitive prognosis in chronic temporal lobe epilepsy
Hermann, B. P., Seidenberg, M., Dow, C., Jones, J. E., Rutecki, P. A., Bhattacharya, A., & Bell, B. D. (2006) · Annals of Neurology · doi:10.1002/ana.20872 · Cited by 299 · see citing works
FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein
Westmark, C. J., & Malter, J. S. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050052 · Cited by 292 · see citing works
Tai, X. Y., Koepp, M., Duncan, J. S., Fox, N., Thompson, P., Baxendale, S., Liu, J. Y. W., Reeves, C., Michalak, Z., & Thom, M. (2016) · Brain · doi:10.1093/brain/aww187 · Cited by 291 · see citing works
Hippocampal interictal epileptiform activity disrupts cognition in humans
Kleen, J. K., Scott, R. C., Holmes, G. L., Roberts, D. W., Rundle, M. M., Testorf, M. E., Lenck‐Santini, P., & Jobst, B. C. (2013) · Neurology · doi:10.1212/wnl.0b013e318297ee50 · Cited by 276 · see citing works
Noebels, J. L. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2010.02909.x · Cited by 261 · see citing works
Both total and phosphorylated tau are increased in Alzheimer's disease
Sjögren, M. J. C. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.5.624 · Cited by 254 · see citing works
Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A
Martin, L., Latypova, X., Wilson, C. M., Magnaudeix, A., Perrin, M.-L., & Terro, F. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.06.008 · Cited by 250 · see citing works
Age at onset of epilepsy, pharmacoresistance, and cognitive outcomes
Berg, A. T., Zelko, F. A. J., Levy, S. R., & Testa, F. M. (2012) · Neurology · doi:10.1212/wnl.0b013e31826c1b55 · Cited by 249 · see citing works
Holth, J. K., Bomben, V. C., Reed, J. G., Inoue, T., Younkin, L., Younkin, S. G., Pautler, R. G., Botas, J., & Noebels, J. L. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3191-12.2013 · Cited by 238 · see citing works
Iijima, K., Ando, K., Takeda, S., Satoh, Y., Seki, T., Itohara, S., Greengard, P., Kirino, Y., Nairn, A. C., & Suzuki, T. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751085.x · Cited by 234 · see citing works
Buckmaster, P. S., Ingram, E. A., & Wen, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4179-08.2009 · Cited by 232 · see citing works
Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
Huang, X., Zhang, H., Yang, J., Wu, J., McMahon, J. J., Lin, Y., Cao, Z., Gruenthal, M., & Huang, Y. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.024 · Cited by 231 · see citing works
Kirouac, L., Rajic, A. J., Cribbs, D. H., & Padmanabhan, J. (2017) · eneuro · doi:10.1523/eneuro.0149-16.2017 · Cited by 207 · see citing works
Activation of the Unfolded Protein Response Is an Early Event in Alzheimer’s and Parkinson’s Disease
Hoozemans, J. J. M., van Haastert, E. S., Nijholt, D. A. T., Rozemüller, A. J. M., & Scheper, W. (2012) · Neurodegenerative Diseases · doi:10.1159/000334536 · Cited by 202 · see citing works
Patients with epilepsy: Cognitively compromised before the start of antiepileptic drug treatment?
Taylor, J., Kolamunnage‐Dona, R., Marson, A. G., Smith, P. E. M., Aldenkamp, A. P., Baker, G. A., & on behalf of the SANAD study group (2009) · Epilepsia · doi:10.1111/j.1528-1167.2009.02195.x · Cited by 202 · see citing works
Aplin, A. E., Gibb, G. M., Jacobsen, J. S., Gallo, J., & Anderton, B. H. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67020699.x · Cited by 201 · see citing works
Prevalence and Incidence of Drug-Resistant Mesial Temporal Lobe Epilepsy in the United States
Asadi‐Pooya, A. A., Stewart, G. R., Abrams, D. J., & Sharan, A. D. (2016) · World Neurosurgery · doi:10.1016/j.wneu.2016.12.074 · Cited by 199 · see citing works
Sheng, J. G., Boop, F. A., Mrak, R. E., & Griffin, W. S. T. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63051872.x · Cited by 198 · see citing works
Caspase-2 cleavage of tau reversibly impairs memory
Zhao, X., Kotilinek, L. A., Smith, B., Hlynialuk, C., Zahs, K., Ramsden, M., Cleary, J., & Ashe, K. H. (2016) · Nature Medicine · doi:10.1038/nm.4199 · Cited by 187 · see citing works
Talos, D. M., Sun, H., Zhou, X., Fitzgerald, E. C., Jackson, M. C., Klein, P., Lan, V. J., Joseph, A., & Jensen, F. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035885 · Cited by 182 · see citing works
Self-citationEarly Alterations of AMPA Receptors Mediate Synaptic Potentiation Induced by Neonatal Seizures
Rakhade, S. N., Zhou, C., Aujla, P. K., Fishman, R. E., Sucher, N. J., & Jensen, F. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1734-08.2008 · Cited by 180 · see citing works
Self-citationGoto, J., Talos, D. M., Klein, P., Qin, W., Chekaluk, Y. I., Anderl, S., Malinowska, I. A., Nardo, A. D., Bronson, R. T., Chan, J. A.-W., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106454108 · Cited by 179 · see citing works
Self-citationBorn, H. A., Kim, J.-Y., Savjani, R. R., Das, P., Dabaghian, Y. A., Guo, Q., Yoo, J. W., Schuler, D. R., Cirrito, J. R., Zheng, H., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5171-13.2014 · Cited by 178 · see citing works
Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model
Schoch, K. M., DeVos, S. L., Miller, R. L., Chun, S. J., Norrbom, M., Wozniak, D. F., Dawson, H. N., Bennett, C. F., Rigo, F., & Miller, T. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.042 · Cited by 175 · see citing works
van Vliet, E. A., Forte, G., Holtman, L., den Burger, J. C. G., Sinjewel, A., de Vries, H. E., Aronica, E., & Gorter, J. A. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03513.x · Cited by 173 · see citing works
Devi, L., & Ohno, M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.04.031 · Cited by 169 · see citing works
Subthalamic Nucleus Deep Brain Stimulation: Basic Concepts and Novel Perspectives
Hamani, C., Florence, G., Heinsen, H., Plantinga, B. R., Temel, Y., Uludaǧ, K., Alho, E. J. L., Teixeira, M. J., Amaro, E., & Fonoff, E. T. (2017) · eNeuro · doi:10.1523/eneuro.0140-17.2017 · Cited by 169 · see citing works
Should cognition be screened in new-onset epilepsies? A study in 247 untreated patients
Witt, J., & Helmstaedter, C. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6526-2 · Cited by 168 · see citing works
Senile plaques in temporal lobe epilepsy
Mackenzie, I. R. A., & Miller, L. A. (1994) · Acta Neuropathologica · doi:10.1007/bf00294177 · Cited by 168 · see citing works
Thom, M., Liu, J. Y. W., Thompson, P., Phadke, R., Narkiewicz, M., Martinian, L., Marsdon, D., Koepp, M., Caboclo, L., Catarino, C. B., et al. (2011) · Brain · doi:10.1093/brain/awr209 · Cited by 167 · see citing works
Di Nardo, A., Kramvis, I., Cho, N., Sadowski, A., Meikle, L., Kwiatkowski, D. J., & Sahin, M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0778-09.2009 · Cited by 165 · see citing works
Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
Youmans, K. L., Tai, L. M., Kanekiyo, T., Stine Jr, W. B., Michon, S.-C., Nwabuisi-Heath, E., Manelli, A. M., Fu, Y., Riordan, S., Eimer, W. A., et al. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-8 · Cited by 164 · see citing works
Miners, J. S., Helmond, Z. V., Chalmers, K. A., Wilcock, G. K., Love, S., & Kehoe, P. G. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000240463.87886.9a · Cited by 153 · see citing works
Interictal epileptiform activity outside the seizure onset zone impacts cognition
Ung, H., Cazares, C., Nanivadekar, A. C., Kini, L. G., Wagenaar, J., Becker, D. A., Krieger, A. Μ., Lucas, T. H., Litt, B., & Davis, K. A. (2017) · Brain · doi:10.1093/brain/awx143 · Cited by 148 · see citing works
Self-citationPuvenna, V., Engeler, M., Banjara, M., Brennan, C., Schreiber, P., Dadas, A., Bahrami, A., Solanki, J., Bandyopadhyay, A., Morris, J. K., et al. (2016) · Brain Research · doi:10.1016/j.brainres.2015.11.007 · Cited by 144 · see citing works
Epilepsy as a spectrum disorder: Implications from novel clinical and basic neuroscience
Jensen, F. E. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2010.02904.x · Cited by 141 · see citing works
Self-citationBraak, H., Zetterberg, H., Tredici, K. D., & Blennow, K. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1139-0 · Cited by 141 · see citing works
Tau reduction prevents disease in a mouse model of <scp>D</scp> ravet syndrome
Gheyara, A. L., Ponnusamy, R., Djukic, B., Craft, R. J., Ho, K., Guo, W., Finucane, M. M., Sanchez, P. E., & Mucke, L. (2014) · Annals of Neurology · doi:10.1002/ana.24230 · Cited by 138 · see citing works
Hilbich, C., Mönning, U., Grund, C., Masters, C. L., & Beyreuther, K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74350-6 · Cited by 137 · see citing works
Lee, K. J., Moussa, C., Lee, Y. J., Sung, Y., Howell, B. W., Turner, R. S., Pak, D. T. S., & Hoe, H.-S. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.078 · Cited by 133 · see citing works
Seizures in Alzheimer’s disease
Born, H. A. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.051 · Cited by 131 · see citing works
Liu, S.-J., Zheng, P., Wright, D. K., Dezsi, G., Braine, E., Nguyen, T., Corcoran, N. M., Johnston, L. A., Hovens, C. M., Mayo, J. N., et al. (2016) · Brain · doi:10.1093/brain/aww116 · Cited by 127 · see citing works
Chin, J., & Scharfman, H. E. (2013) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.11.040 · Cited by 123 · see citing works
Standen, C. L., Brownlees, J., Grierson, A. J., Kesavapany, S., Lau, K., McLoughlin, D. M., & Miller, C. C. J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00102.x · Cited by 121 · see citing works
P70 S6 kinase mediates tau phosphorylation and synthesis
Pei, J.-J., An, W., Zhou, X., Nishimura, T., Norberg, J., Benedikz, E., Götz, J., & Winblad, B. G. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.11.059 · Cited by 119 · see citing works
Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primary screen
Lalonde, R., Dumont, M., Staufenbiel, M., & Strazielle, C. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.06.020 · Cited by 116 · see citing works
Seizure susceptibility and mortality in mice that over-express amyloid precursor protein.
Westmark, C. J., Westmark, P. R., Beard, A. M., Hildebrandt, S. M., & Malter, J. S. (2008) · PubMed Central · Cited by 116 · see citing works
The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity
Hoe, H., Fu, Z., Makarova, A., Lee, J.-Y., Lu, C., Feng, L., Pajoohesh‐Ganji, A., Matsuoka, Y., Hyman, B. T., Ehlers, M., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900141200 · Cited by 114 · see citing works
Structural brain changes in medically refractory focal epilepsy resemble premature brain aging
Pardoe, H., Cole, J. H., Blackmon, K., Thesen, T., & Kuzniecky, R. (2017) · Epilepsy Research · doi:10.1016/j.eplepsyres.2017.03.007 · Cited by 114 · see citing works
Di, J., Cohen, L. S., Corbo, C. P., Phillips, G. R., Idrissi, A. E., & Alonso, A. D. C. (2016) · Scientific Reports · doi:10.1038/srep20833 · Cited by 113 · see citing works
Sun, Y.-X., Ji, X., Mao, X., Xie, L., Jia, J., Galván, V., Greenberg, D. A., & Jin, K. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-131124 · Cited by 112 · see citing works
mTor mediates tau localization and secretion: implication for Alzheimer’s disease
Tang, Z., Ioja, E., Bereczki, E., Hultenby, K., Li, C., Guan, Z., Winblad, B., & Pei, J.-J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.03.003 · Cited by 112 · see citing works
Ziyatdinova, S., Gurevicius, K., Kutchiashvili, N., Bolkvadze, T., Nissinen, J., Tanila, H., & Pitkänen, A. (2011) · Epilepsy Research · doi:10.1016/j.eplepsyres.2011.01.003 · Cited by 106 · see citing works
Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2
Yan, R. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00097 · Cited by 105 · see citing works
Caccamo, A., Branca, C., Talboom, J. S., Shaw, D. M., Turner, D., Ma, L., Messina, A. A., Huang, Z., Wu, J., & Oddo, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2781-15.2015 · Cited by 101 · see citing works
Gourmaud, S., Paquet, C., Dumurgier, J., Pace, C., Bouras, C., Gray, F., Laplanche, J., MEURS, E. F., Mouton‐Liger, F., & Hugon, J. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140062 · Cited by 95 · see citing works
Self-citationEnfermedad de Alzheimer de inicio precoz y de inicio tardío: ¿son la misma entidad?
Tellechea, P., Pujol, N., Esteve‐Belloch, P., Echeveste, B., García-Eulate, M. R., Arbizu, J., & Riverol, M. (2015) · Neurología · doi:10.1016/j.nrl.2015.08.002 · Cited by 86 · see citing works
Amyloid Clearance as a Treatment Target Against Alzheimer's Disease
Kurz, A., & Perneczky, R. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-102139 · Cited by 83 · see citing works
Endoplasmic Reticulum Stress and Apoptosis Signaling in Human Temporal Lobe Epilepsy
Yamamoto, A., Murphy, N., Schindler, C. K., So, N. K., Stöhr, S., Taki, W., Prehn, J. H. M., & Henshall, D. C. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000202886.22082.2a · Cited by 82 · see citing works
Crespo‐Biel, N., Canudas, A. M., Camins, A., & Pallàs, M. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.10.002 · Cited by 82 · see citing works
Early- and late-onset Alzheimer disease: Are they the same entity?
Tellechea, P., Pujol, N., Esteve‐Belloch, P., Echeveste, B., García-Eulate, M. R., Arbizu, J., & Riverol, M. (2017) · Neurología (English Edition) · doi:10.1016/j.nrleng.2015.08.009 · Cited by 81 · see citing works
Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.
Jones, N. C., Nguyen, T., Corcoran, N. M., Velakoulis, D., Chen, T., Grundy, R., O'Brien, T. J., & Hovens, C. M. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.005 · Cited by 81 · see citing works
Bell, J. J. L., Rakhade, S. N., Klein, P., Obeid, M., Jackson, M. C., Joseph, A., & Jensen, F. E. (2013) · Epilepsia · doi:10.1111/epi.12378 · Cited by 76 · see citing works
Self-citationAssociation Between Childhood-Onset Epilepsy and Amyloid Burden 5 Decades Later
Joutsa, J., Rinne, J. O., Hermann, B. P., Karrasch, M., Anttinen, A., Shinnar, S., & Sillanpää, M. L. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.6091 · Cited by 75 · see citing works
Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy
Talos, D. M., Jacobs, L., Gourmaud, S., Coto, C. A., Sun, H., Lim, K., Lucas, T. H., Davis, K. A., Martinez‐Lage, M., & Jensen, F. E. (2018) · Annals of Neurology · doi:10.1002/ana.25149 · Cited by 74 · see citing works
Self-citationDysregulation of tau phosphorylation in mouse brain during excitotoxic damage.
Liang, Z., Liu, F., Iqbal, K., Grundke-Iqbal, I., & Gong, C.-X. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1069 · Cited by 73 · see citing works
Pasciuto, E., Ahmed, T., Wahle, T., Gardoni, F., D’Andrea, L., Pacini, L., Jacquemont, S., Tassone, F., Balschun, D., Dotti, C. G., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.032 · Cited by 71 · see citing works
Seizure resistance without parkinsonism in aged mice after tau reduction
Li, Z., Hall, A. M., Kelinske, M., & Roberson, E. D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.05.001 · Cited by 71 · see citing works
Espíndola, S. L., Damianich, A., Alvarez, R. J., Sartor, M., Belforte, J. E., Ferrario, J. E., Gallo, J.-M., & Avale, M. E. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.079 · Cited by 65 · see citing works
Yan, X.-X., Cai, Y., Shelton, J., Deng, S.-H., Luo, X.-G., Oddo, S., LaFerla, F. M., Cai, H., Rose, G. M., & Patrylo, P. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048782 · Cited by 64 · see citing works
Temporal lobe epilepsy is associated with distinct cognitive phenotypes
Elverman, K. H., Resch, Z. J., Quasney, E. E., Sabsevitz, D. S., Binder, J. R., & Swanson, S. J. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.04.015 · Cited by 64 · see citing works
Westmark, C. J. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.122 · Cited by 63 · see citing works
Hornberger, T. A., Sukhija, K. B., Wang, X.-R., & Chien, S. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.08.045 · Cited by 63 · see citing works
Spigolon, G., Veronesi, C., Bonny, C., & Vercelli, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07158.x · Cited by 62 · see citing works
Brain structure and aging in chronic temporal lobe epilepsy
Dabbs, K., Becker, T., Jones, J. E., Rutecki, P. A., Seidenberg, M., & Hermann, B. P. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03447.x · Cited by 62 · see citing works
Morales‐Corraliza, J., Mazzella, M. J., Berger, J. D., Diaz, N. S., Choi, J. H. K., Levy, E., Matsuoka, Y., Planel, E., & Mathews, P. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007134 · Cited by 59 · see citing works
Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus
Torres-Peraza, J. F., Engel, T., Martín‐Ibáñez, R., Sanz‐Rodriguez, A., Fernández-Fernández, M. R., Esgleas, M., Canals, J. M., Henshall, D. C., & Lucas, J. J. (2013) · Brain · doi:10.1093/brain/awt044 · Cited by 58 · see citing works
Effect of epileptic seizures on the cerebrospinal fluid–A systematic retrospective analysis.
Tumani, H., Jobs, C., Brettschneider, J., Hoppner, A. C., Kerling, F., & Fauser, S. (2015) · Epilepsy Research · doi:10.1016/j.eplepsyres.2015.04.004 · Cited by 57 · see citing works
Cell injury and Premature Neurodegeneration in Focal Malformations of Cortical Development
Iyer, A. M., Prabowo, A. S., Anink, J. J., Spliet, W. G. M., van Rijen, P. C., & Aronica, E. (2013) · Brain Pathology · doi:10.1111/bpa.12060 · Cited by 56 · see citing works
Hara, M., Hirokawa, K., Kamei, S., & Uchihara, T. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1097-6 · Cited by 55 · see citing works
Perez, S. E., Miguel, J. C., He, B., Malek‐Ahmadi, M. H., Abrahamson, E. E., Ikonomović, M. D., Lott, I. T., Doran, E. W., Alldred, M. J., Ginsberg, S. D., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01965-6 · Cited by 47 · see citing works
Transcriptional and post‐transcriptional regulation of β‐secretase
Tamagno, E., Guglielmotto, M., Monteleone, D., Vercelli, A., & Tabaton, M. (2012) · IUBMB Life · doi:10.1002/iub.1099 · Cited by 40 · see citing works
Expression of β-amyloid precursor protein in refractory epilepsy
Sima, X., Xu, J., Li, J., Zhong, W., & You, C. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.1977 · Cited by 37 · see citing works
Expression of neurodegenerative disease‐related proteins and caspase‐3 in glioneuronal tumours
Prabowo, A. S., Iyer, A. M., Veersema, T. J., Anink, J. J., Meeteren, A. Y. N. S., Spliet, W. G. M., van Rijen, P. C., Ferrier, C. H., Thom, M., & Aronica, E. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12143 · Cited by 36 · see citing works
Involvement of IRE1α signaling in the hippocampus in patients with mesial temporal lobe epilepsy
Liu, G., Guo, H., Guo, C., Zhao, S., Gong, D., & Zhao, Y. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.10.004 · Cited by 35 · see citing works
Tai, T. Y., Warner, L. N., Jones, T. D., Jung, S., Concepcion, F. A., Skyrud, D. W., Fender, J. S., Liu, Y. K., Williams, A. D., Neumaier, J. F., et al. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.024 · Cited by 35 · see citing works
Tian, F., Zeng, C., Ma, Y., Guo, T.-H., Chen, J.-M., Chen, Y., Cai, X., Li, F.-R., Wang, X., Huang, W., et al. (2010) · PubMed · Cited by 34 · see citing works
Carnevalli, L. S., Pereira, M. G., Jaqueta, C. B., Alves, V. S., Paiva, V. N., Vattem, K. M., Wek, R. C., Mello, L. E., & Castilho, B. A. (2006) · Biochemical Journal · doi:10.1042/bj20051643 · Cited by 29 · see citing works
Kodam, A., Ourdev, D., Maulik, M., Hariharakrishnan, J., Banerjee, M., Yu⁃xiang, W. A. N. G., & Kar, S. (2018) · Brain Pathology · doi:10.1111/bpa.12617 · Cited by 27 · see citing works
APP Causes Hyperexcitability in Fragile X Mice
Westmark, C. J., Chuang, S.-C., Hays, S. A., Filon, M. J., Ray, B. C., Westmark, P. R., Gibson, J. R., Huber, K. M., & Wong, R. K. S. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00147 · Cited by 24 · see citing works
How many adults with temporal epilepsy have a mild course and do not require epilepsy surgery?
Hernández‐Ronquillo, L., Buckley, S., Ladino, L. D., Wu, A., Moien‐Afshari, F., Rizvi, S., & Tellez-Zenteno, J. F. (2016) · Epileptic Disorders · doi:10.1684/epd.2016.0822 · Cited by 22 · see citing works
Jang, S.-S., Royston, S. E., Lee, G., Wang, S., & Chung, H. J. (2016) · Neural Plasticity · doi:10.1155/2016/2123748 · Cited by 21 · see citing works
The c-Jun N-terminal kinase inhibitor SP600125 is neuroprotective in amygdala kindled rats
Chen, X., Wu, J., Hua, D., Shu, K., Wang, J., Li, L., & Lei, T. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.082 · Cited by 17 · see citing works
Novel monoclonal antibodies targeting the microtubule-binding domain of human tau
Croft, C. L., Moore, B. D., Ran, Y., Chakrabarty, P., Levites, Y., Golde, T. E., & Giasson, B. I. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195211 · Cited by 16 · see citing works
Osler, M., Mortensen, E. L., Christensen, K., & Christensen, G. T. (2018) · International Journal of Epidemiology · doi:10.1093/ije/dyy018 · Cited by 15 · see citing works
Chen, J., Zheng, G., Guo, H., & Shi, Z.-N. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0236-4 · Cited by 13 · see citing works
Flagged first, then by citations
1 of the 134 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Gheyara AL, Ponnusamy R, Djukic B, Craft RJ, Ho K, Guo W, et al. Tau reduction prevents disease in a mouse model of Dravet syn- drome. Ann Neurol 2014; 76: 443-56.
Cited by
Sorted by citations
Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy
Hermann, B. P., Struck, A. F., Busch, R. M., Reyes, A., Kaestner, E. J., & McDonald, C. R. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00555-z · Cited by 153 · see citing works
Amyloid-β: a potential link between epilepsy and cognitive decline
Romoli, M., Sen, A., Parnetti, L., Calabresi, P., & Costa, C. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00505-9 · Cited by 132 · see citing works
Balestrini, S., Arzimanoglou, A. A., Blümcke, I., Scheffer, I. E., Wiebe, S., Zelano, J., & Walker, M. C. (2021) · Epileptic Disorders · doi:10.1684/epd.2021.1255 · Cited by 131 · see citing works
Kamondi, A., Grigg-Damberger, M. M., Löscher, W., Tanila, H., & Horvath, A. A. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00932-4 · Cited by 102 · see citing works
Neurovascular unit dysfunction as a mechanism of seizures and epilepsy during aging
van Vliet, E. A., & Marchi, N. (2022) · Epilepsia · doi:10.1111/epi.17210 · Cited by 68 · see citing works
Alzheimer Disease and Epilepsy
Fang, Y., Si, X., Wang, J., Wang, Z., Chen, Y., Liu, Y., Yan, Y., Tian, J., Zhang, B., & Pu, J. (2023) · Neurology · doi:10.1212/wnl.0000000000207423 · Cited by 66 · see citing works
Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways
Canet, G., Zub, E., Zussy, C., Hernandez, C., Blaquière, M., Garcia, V., Vitalis, M., de Bock, F., Moreno, M. P., Audinat, É., et al. (2022) · Epilepsia · doi:10.1111/epi.17186 · Cited by 65 · see citing works
Anti-Inflammatory Activity of Melatonin: a Focus on the Role of NLRP3 Inflammasome
Ashrafizadeh, M., Najafi, M., Kaviyani, N., Mohammadinejad, R., Farkhondeh, T., & Samarghandian, S. (2021) · Inflammation · doi:10.1007/s10753-021-01428-9 · Cited by 64 · see citing works
Proteomic differences in the hippocampus and cortex of epilepsy brain tissue
Pires, G., Leitner, D., Drummond, E., Kanshin, E., Nayak, S., Askenazi, M., Faustin, A., Friedman, D. J., Debure, L., Ueberheide, B. M., et al. (2021) · Brain Communications · doi:10.1093/braincomms/fcab021 · Cited by 61 · see citing works
Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer’s disease and 5XFAD mice
Barbour, A. J., Gourmaud, S., Lancaster, E., Li, X., Stewart, D. A., Hoag, K., Irwin, D. J., Talos, D. M., & Jensen, F. E. (2024) · Brain · doi:10.1093/brain/awae126 · Cited by 58 · see citing works
Self-citationTombini, M., Assenza, G., Ricci, L., Lanzone, J., Boscarino, M., Vico, C., Magliozzi, A., & Lazzaro, V. D. (2021) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-200286 · Cited by 54 · see citing works
The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease
Gourmaud, S., Stewart, D. A., Irwin, D. J., Roberts, N., Barbour, A. J., Eberwine, G., O’Brien, W. T., Vassar, R. J., Talos, D. M., & Jensen, F. E. (2021) · Brain · doi:10.1093/brain/awab268 · Cited by 48 · see citing works
Self-citationFyn-tau Ablation Modifies PTZ-Induced Seizures and Post-seizure Hallmarks of Early Epileptogenesis
Putra, M. R. E., Puttachary, S., Liu, G., Lee, G. S., & Thippeswamy, T. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.592374 · Cited by 47 · see citing works
Cytoskeleton and Associated Proteins: Pleiotropic JNK Substrates and Regulators
Benoit, B., Baillet, A., & Poüs, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168375 · Cited by 45 · see citing works
Epilepsy, antiepileptic drugs and dementia
Beghi, E., & Beghi, M. (2020) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000802 · Cited by 44 · see citing works
eIF2-dependent translation initiation: Memory consolidation and disruption in Alzheimer’s disease
Oliveira, M. M., & Klann, E. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.07.009 · Cited by 41 · see citing works
Badawi, G. A., Shokr, M. M., Elshazly, S. M., Zaki, H. F., & Mohamed, A. F. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176851 · Cited by 39 · see citing works
Paudel, Y. N., Angelopoulou, E., Piperi, C., Othman, I., & Shaikh, M. F. (2020) · Biology · doi:10.3390/biology9060122 · Cited by 42 · see citing works
Aluminum and Tau in Neurofibrillary Tangles in Familial Alzheimer’s Disease
Mold, M. J., O’Farrell, A., Morris, B., & Exley, C. (2021) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-210011 · Cited by 39 · see citing works
Mechanisms Involved in Epileptogenesis in Alzheimer’s Disease and Their Therapeutic Implications
Altuna, M., Olmedo‐Saura, G., Carmona‐Iragui, M., & Fortea, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084307 · Cited by 39 · see citing works
Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy
Casillas-Espinosa, P. M., Anderson, A., Harutyunyan, A., Li, C. N., Lee, J.-Y., Braine, E. L., Brady, R. D., Sun, M., Huang, C., Barlow, C. K., et al. (2023) · eLife · doi:10.7554/elife.78877 · Cited by 37 · see citing works
Akel, S., Asztély, F., Banote, R. K., Axelsson, M., Zetterberg, H., & Zelano, J. (2023) · Epilepsia · doi:10.1111/epi.17713 · Cited by 36 · see citing works
Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms
Hwang, K., Vaknalli, R. N., Addo-Osafo, K., Vicente, M., & Vossel, K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.903973 · Cited by 35 · see citing works
Similar brain proteomic signatures in Alzheimer’s disease and epilepsy
Leitner, D., Pires, G., Kavanagh, T., Kanshin, E., Askenazi, M., Ueberheide, B. M., Devinsky, O., Wısnıewskı, T., & Drummond, E. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02683-4 · Cited by 35 · see citing works
Hyperphosphorylated Tau in Mesial Temporal Lobe Epilepsy: a Neuropathological and Cognitive Study
Toscano, E. C. D. B., Vieira, É. L. M., Grinberg, L. T., Rocha, N. P., Brant, J. A. S., Paradela, R. S., Giannetti, A. V., Suemoto, C. K., Leite, R. E. P., Nitríni, R., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-022-03190-x · Cited by 31 · see citing works
Alzheimer’s disease and epilepsy: An increasingly recognized comorbidity
Yang, F., Chen, L., Yu, Y., Xu, T., Chen, L., Yang, W., Wu, Q., & Han, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.940515 · Cited by 31 · see citing works
Mold, M. J., O’Farrell, A., Morris, B., & Exley, C. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200838 · Cited by 29 · see citing works
Low prevalence of amyloid and tau pathology in drug-resistant temporal lobe epilepsy.
Silva, J. C., Vivash, L., Malpas, C. B., Hao, Y., McLean, C., Chen, Z., O'Brien, T. J., Jones, N. C., & Kwan, P. (2021) · Epilepsia · doi:10.1111/epi.17086 · Cited by 28 · see citing works
Assessment of tau phosphorylation and β‐amyloid pathology in human drug‐resistant epilepsy
Aroor, A., Nguyen, P., Li, Y., Das, R. R., Lugo, J. N., & Brewster, A. L. (2023) · Epilepsia Open · doi:10.1002/epi4.12744 · Cited by 26 · see citing works
Kodam, A., Ourdev, D., Maulik, M., Hariharakrishnan, J., Banerjee, M., Yu⁃xiang, W. A. N. G., & Kar, S. (2018) · Brain Pathology · doi:10.1111/bpa.12617 · Cited by 27 · see citing works
The crosstalk between epilepsy and dementia: A systematic review and meta-analysis
Chen, L., Yang, W., Yang, F., Yu, Y., Xu, T., Wang, D., Zhao, Q., Wu, Q., & Han, Y. (2024) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2024.109640 · Cited by 26 · see citing works
Zhen, Z., Guo, M., Li, H.-M., Guo, O., Zhen, J., Fu, J., & Tan, G.-J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.683483 · Cited by 23 · see citing works
Beyond Seizure Control: Treating Comorbidities in Epilepsy via Targeting of the P2X7 Receptor
Gil, B., Smith, J., Tang, Y., Illés, P., & Engel, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042380 · Cited by 26 · see citing works
The association of seizure control with neuropathology in dementia
Zawar, I., Łuniewski, A., Gundlapalli, R., Manning, C. A., Parikh, P., Kapur, J., & Quigg, M. (2025) · Brain · doi:10.1093/brain/awaf017 · Cited by 25 · see citing works
Hautecloque, G., Sellal, F., Bousiges, O., Phillipi, N., Blanc, F., & Cretin, B. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221197 · Cited by 24 · see citing works
Late-onset temporal lobe epilepsy: insights from brain atrophy and Alzheimer’s disease biomarkers
Ballerini, A., Biagioli, N., Carbone, C., Chiari, A., Tondelli, M., Vinceti, G., Bedin, R., Malagoli, M., Genovese, M., Scolastico, S., et al. (2024) · Brain · doi:10.1093/brain/awae207 · Cited by 24 · see citing works
Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale
You, J., Huang, H., Chan, C. T. Y., & Li, L. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.779558 · Cited by 23 · see citing works
Qiao, Q., Qu, Z., Shuang, T., Cao, H., Zhang, Y., Sun, C., Jia, L., & Wang, W. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s376979 · Cited by 22 · see citing works
CSF biomarkers in patients with epilepsy in Alzheimer’s disease: a nation-wide study
Banote, R. K., Håkansson, S., Zetterberg, H., & Zelano, J. (2022) · Brain Communications · doi:10.1093/braincomms/fcac210 · Cited by 22 · see citing works
Lopes, F. B., Aranha, C. M. S. Q., & Fernandes, J. P. S. (2021) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13866 · Cited by 21 · see citing works
The Proteoform Landscape of Tau from the Human Brain
Xu, T., Su, T., Soye, B. J. D., Kandi, S., Huang, C., Wilkins, J. T., Castellani, R. J., Kafader, J. O., Patrie, S. M., Vassar, R. J., et al. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5c00139 · Cited by 20 · see citing works
Kalyvas, A.-C., Dimitriou, M., Ioannidis, P., Grigoriadis, N., & Afrantou, T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13133879 · Cited by 20 · see citing works
Late-onset epilepsy and the risk of dementia: a systematic review and meta-analysis
Huang, L., Fu, C., Li, J., & Peng, S. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02118-8 · Cited by 19 · see citing works
Hashemi, P., & Ahmadi, S. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03274-2 · Cited by 19 · see citing works
Ren, Z., Yue, M., Han, X., Zhao, Z., Wang, B., Hong, Y., Zhao, T., Wang, N., Zhao, P., Hong, Y., et al. (2023) · Epileptic Disorders · doi:10.1002/epd2.20044 · Cited by 19 · see citing works
Timalsina, B., Haque, M. N., Choi, H. J., Dash, R., & Moon, I. S. (2023) · Phytotherapy Research · doi:10.1002/ptr.7777 · Cited by 18 · see citing works
Xu, X., Mei, B., Yang, Y., Li, J., Weng, J., Yang, Y., Zhu, Q., Zhang, H., & Liu, X. (2025) · International Journal of Biological Sciences · doi:10.7150/ijbs.109315 · Cited by 17 · see citing works
Peek, S. I., Twele, F., Meller, S., Packer, R. M. A., & Volk, H. A. (2023) · The Veterinary Journal · doi:10.1016/j.tvjl.2023.106061 · Cited by 17 · see citing works
Putra, M. R. E., Rao, N. S., Gardner, C., Liu, G., Trommater, J., Bunney, M., Gage, M., Bassuk, A. G., Hefti, M. M., Lee, G. S., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae327 · Cited by 17 · see citing works
Modulation of neuroinflammation as a therapeutic strategy for the control of epilepsy
Ramos, A. J., Lazarowski, A., Vega-García, A., Buriticá, E., Auzmendi, J., Becerra-Hernández, L. V., Nuñez-Lumbreras, M. D. L. Á., Orozco-Suárez, S. A., Alves, S. S., Garcia‐Cairasco, N., et al. (2025) · Seizure · doi:10.1016/j.seizure.2025.08.023 · Cited by 18 · see citing works
Wu, Q., Wang, H., Liu, X., Zhao, Y., & Zhang, J. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.823908 · Cited by 16 · see citing works
Serum neurofilament light chain in patients with epilepsy and cognitive impairment
Ueda, M., Suzuki, M., Hatanaka, M., Nakamura, T., Hirayama, M., & Katsuno, M. (2023) · Epileptic Disorders · doi:10.1002/epd2.20024 · Cited by 16 · see citing works
The Bidirectional Relationship Between Epilepsy and Alzheimer’s Disease
Stewart, D., & Johnson, E. L. (2025) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-025-01404-y · Cited by 16 · see citing works
Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease
Juvenal, G. D. A., Higa, G. S. V., Marques, L. B., Zampieri, T. T., Viana, F. J. C., Britto, L. R. G., Tang, Y. C., Illés, P., Virgilio, F. D., Ulrich, H., et al. (2024) · Purinergic Signalling · doi:10.1007/s11302-024-10034-x · Cited by 14 · see citing works
Amyloid deposition in adults with drug‐resistant temporal lobe epilepsy
Fonseca, E., Lallana, S., Ortega, G., Cano, A. C., Sarria‐Estrada, S., Pareto, D., Quintana, M., Lorenzo‐Bosquet, C., López‐Maza, S., Gifreu, A., et al. (2024) · Epilepsia · doi:10.1111/epi.18142 · Cited by 14 · see citing works
Localized proteomic differences in the choroid plexus of Alzheimer's disease and epilepsy patients
Leitner, D., Kanshin, E., Faustin, A., Thierry, M., Friedman, D. J., Devore, S., Ueberheide, B. M., Devinsky, O., & Wısnıewskı, T. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1221775 · Cited by 15 · see citing works
Zou, Y., Wang, C., Li, H., Zhong, M., Lin, J., Hu, Y., Chen, Z., & Gan, C. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1500105 · Cited by 13 · see citing works
Progressive Dysregulation of Tau Phosphorylation in an Animal Model of Temporal Lobe Epilepsy
Concepcion, F. A., Ekstrom, N. A., Khan, M. N., Estes, O., & Poolos, N. P. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.04.020 · Cited by 12 · see citing works
Cognitive decline in adult-onset temporal lobe epilepsy: Insights from aetiology
Hernández, G., Sala, J., Adell, V., Rico, I., Gasa‐Roqué, A., Morandeira, F., Campdelacreu, J., Gascón, J., & Falip, M. (2024) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2024.108159 · Cited by 12 · see citing works
Aluminium co-localises with Biondi ring tangles in Parkinson’s disease and epilepsy
Mold, M. J., & Exley, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-05627-8 · Cited by 12 · see citing works
Identification of common core ion channel genes in epilepsy and Alzheimer’s disease
Tang, T. S., Li, X., Yu, E., Li, M., & Pan, X. (2023) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-023-03447-x · Cited by 12 · see citing works
Exploring biomarkers of neurodegeneration in epilepsy: Critical insights
Farhan, R., Hashmi, S. A., Kapur, J., D’Abreu, A., Punia, V., Manning, C. A., Smith, V. L., & Zawar, I. (2025) · Epileptic Disorders · doi:10.1002/epd2.70023 · Cited by 13 · see citing works
Polak-Szabela, A., Dziembowska, I., Bracha, M., Pedrycz, A., Kędziora–Kornatowska, K., & Kozakiewicz, M. (2021) · Clinical Interventions in Aging · doi:10.2147/cia.s310750 · Cited by 11 · see citing works
Sokol, D. K., & Lahiri, D. K. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1201723 · Cited by 11 · see citing works
Tackling seizures in patients with Alzheimer’s disease
Tombini, M., Boscarino, M., & Lazzaro, V. D. (2023) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2023.2278487 · Cited by 11 · see citing works
Understanding epileptogenesis from molecules to network alteration
Park, K. (2024) · encephalitis · doi:10.47936/encephalitis.2024.00038 · Cited by 11 · see citing works
Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting
Sandoval, K. E., & WITT, K. A. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.124.001117 · Cited by 14 · see citing works
Dahal, A., Karthivashan, G., & Kar, S. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.02.010 · Cited by 11 · see citing works
Lu, M., Feng, R., Zhang, C., Xiao, Y., & Yin, C. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03382-z · Cited by 10 · see citing works
Ueda, S., Kuzuya, A., Kawata, M., Okawa, K., Honjo, C., Wada, T., Matsumoto, M., Goto, K., Miyamoto, M., Yonezawa, A., et al. (2023) · The FASEB Journal · doi:10.1096/fj.202300837r · Cited by 10 · see citing works
Maslarova, A., Shin, J. N., Navas-Olivé, A., Vöröslakos, M., Hamer, H. M., Doerfler, A., Henin, S. E., Buzsáki, G., & Liu, A. A. (2025) · Nature Communications · doi:10.1038/s41467-025-66562-6 · Cited by 10 · see citing works
Volumetric and structural connectivity abnormalities co-localise in TLE
Horsley, J., Schroeder, G. M., Thomas, R. H., de Tisi, J., Vos, S. B., Winston, G. P., Duncan, J. S., Wang, Y., & Taylor, P. N. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103105 · Cited by 10 · see citing works
Vivash, L. E., Johns, H. T., Churilov, L. P., MacPhail, S., Casillas-Espinosa, P. M., Malpas, C. B., Shultz, S. R., Tailby, C., Wijayath, M., Reutens, D. C., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-075888 · Cited by 9 · see citing works
Liu, S., He, Z., Shi, W., & Li, J. (2024) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2024.110070 · Cited by 10 · see citing works
Hyperphosphorylated Tau and Cognition in Epilepsy
Witt, J., Andernach, J., Becker, A. J., & Helmstaedter, C. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14020514 · Cited by 9 · see citing works
Neurodegeneration and the immune system: lessons from autoimmune encephalitis
Campetella, L., Smolik, K., Farina, A., Joubert, B., Muñiz‐Castrillo, S., Desestret, V., & Honnorat, J. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13094-0 · Cited by 10 · see citing works
Keezer, M. R. (2025) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001529 · Cited by 9 · see citing works
Hernández, C. F., Villamán, C., Leu, C., Lal, D., Mata, I. F., Klein, A. D., & Pérez‐Palma, E. (2025) · Scientific Reports · doi:10.1038/s41598-025-95755-8 · Cited by 9 · see citing works
Audiogenic Seizures in the Streptozotocin-Induced Rat Alzheimer’s Disease Model
Alves, S. S., de Oliveira, J. A. C., Lazarini-Lopes, W., Servilha‐Menezes, G., Grigório-de-Sant’Ana, M., Vecchio, F. D., Mazzei, R. F., Almeida, S. S., da Silva-Júnior, R. M. P., & Garcia‐Cairasco, N. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230153 · Cited by 8 · see citing works
Yang, P., Huang, Y., Zhu, Y., Wang, Q., Guo, Y., & Li, L. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116928 · Cited by 8 · see citing works
Qin, C., Li, Y., & Wang, K. (2021) · Cells · doi:10.3390/cells10102757 · Cited by 8 · see citing works
Higher plasma neurofilament-light chain concentration in drug-resistant epilepsy
Akel, S., Axelsson, M., Asztély, F., Zetterberg, H., & Zelano, J. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf108 · Cited by 7 · see citing works
Okechukwu, N. G., Zaccone, C., Barbera, L. L., Nobili, A., & D’Amelio, M. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115581 · Cited by 7 · see citing works
Protein profiling and assessment of amyloid beta levels in plasma in canine refractory epilepsy
Phochantachinda, S., Chantong, B., Reamtong, O., & Chatchaisak, D. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1258244 · Cited by 7 · see citing works
MRI-Derived Modeling of Disease Progression Patterns in Patients With Temporal Lobe Epilepsy
Lee, H. M., Fadaie, F., Gill, R. S., Caldairou, B., Sziklas, V., Crane, J., Hong, S., Bernhardt, B. C., Bernasconi, A., & Bernasconi, N. (2024) · Neurology · doi:10.1212/wnl.0000000000209524 · Cited by 7 · see citing works
The prevalence of chronic traumatic encephalopathy in a historical epilepsy post‐mortem collection
Ryniejska, M., Hachami, H. E., Mrzyglod, A., Liu, J. Y. W., & Thom, M. (2024) · Brain Pathology · doi:10.1111/bpa.13317 · Cited by 7 · see citing works
Frackowiak, J., & Mazur‐Kolecka, B. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1160967 · Cited by 7 · see citing works
Epilepsy and Related Disorders
Duncan, J. S., Sander, J. W. A. S., Alim‐Marvasti, A., Balestrini, S., Baxendale, S., Bindman, D., Chinthapalli, K., Chowdhury, F. A., Diehl, B., Eriksson, S. H., et al. (2024) · doi:10.1002/9781119715672.ch10 · Cited by 7 · see citing works
Hyperactive neuronal networks enhance tau spread in an Alzheimer’s disease mouse modelPreprint
Barbour, A. J., Hoag, K., Cornblath, E. J., Chavez, A., Lucas, A., Li, X., Zebrowitz, S. E., Hassman, C., Vazquez, O., Xie, S. X., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.01.625514 · Cited by 6 · see citing works
Self-citationBursts of brain erosion: seizures and age-dependent neurological vulnerability
Cresto, N., Givalois, L., Badaut, J., Janvier, A., Génin, A., Audinat, É., Brewster, A. L., & Marchi, N. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.11.003 · Cited by 6 · see citing works
Takeyama, H., Matsumoto, R., Usami, K., Tojima, M., Shima, A., Honda, M., Sakamoto, M., Murai, T., Hayashi, K., Fushimi, Y., et al. (2025) · Epileptic Disorders · doi:10.1002/epd2.70061 · Cited by 6 · see citing works
Luo, X., Li, C., Yu, X., Kuang, G., Wang, X., Liang, J., & Jiang, J. (2023) · Acta Epileptologica · doi:10.1186/s42494-022-00111-2 · Cited by 6 · see citing works
Li, R., Zeng, K., Liu, J., Yang, Z., & Wang, Y. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.09.046 · Cited by 5 · see citing works
Blood biomarkers of seizures in epilepsy: machine learning reveals altered plasma proteome
Akel, S., Ashtiani, S. H., Sarangdhar, M. A., Axelsson, M., & Zelano, J. (2025) · BMJ Neurology Open · doi:10.1136/bmjno-2025-001321 · Cited by 5 · see citing works
Connectome architecture for gray matter atrophy and surgical outcomes in temporal lobe epilepsy
Lin, Q., Cao, D., Li, W., Zhang, Y., Li, Y., Liu, P., Huang, X. Y., Huang, K., Gong, Q., Zhou, D., et al. (2025) · Epilepsia · doi:10.1111/epi.18343 · Cited by 5 · see citing works
Li, H., Xie, Z., Tian, Y., Zhou, R., Yang, Y., Lin, B., Chen, S., Wu, J., Deng, Z., Li, J., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03318-0 · Cited by 6 · see citing works
Arrozi, A. P., Yanagisawa, D., Kato, T., Akatsu, H., Hashizume, Y., Kaneda, D., & Tooyama, I. (2021) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-210298 · Cited by 5 · see citing works
Do Epilepsy Patients with Cognitive Impairment Have Alzheimer’s Disease-like Brain Metabolism?
He, M., Kolesar, T. A., Goertzen, A. L., Ng, M., & Ko, J. H. (2023) · Biomedicines · doi:10.3390/biomedicines11041108 · Cited by 5 · see citing works
Epilepsy in the Aging Brain: Time to Rethink the Narrative
Zawar, I., Lisgaras, C. P., Sen, A., Jensen, F. E., & Reyes, A. (2026) · Epiliepsy currents/Epilepsy currents · doi:10.1177/15357597261417707 · Cited by 4 · see citing works
Self-citationZhang, Y., Zhang, Y., Wang, H., Fan, D., Ren, X. Z., Kuang, X., Wu, D., & Ma, H. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c05455 · Cited by 4 · see citing works
- Authors
- Gourmaud, S., Shou, H., Irwin, D. J., Sansalone, K., Jacobs, L. M., Lucas, T. H., Marsh, E. D., Davis, K. A., Jensen, F. E., & Talos, D. M.
- Affiliations
- University of Pennsylvania (US)
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Jensen, Frances E
- Talos, Delia M
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-12-13
- Volume
- 143
- Issue
- 1
- Pages
- 191-209
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC6935754
- OpenAlex
- W2996580238
- Cited by
- 155
- References
- 134
- Citations by year
- 2026: 20 · 2025: 33 · 2024: 30 · 2023: 28 · 2022: 18 · 2021: 21 · 2020: 4 · 2018: 1
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Brain (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institutes of Health/National Institute of Neurological Disorders and Stroke (R01NS101156, R21NS105437, R01NS080565, K23NS088341, K23NS092973)
- University Research Foundation
- Brightfocus Foundation (A2016244S)
- Penn Institute on Aging
- Repository Core for Neurological Disorders, Department of Neurology
- Boston Children’s Hospital
- NIH (P30HD018655)
- Center for Neurodegenerative Disease Research (CNDR) at the University of Pennsylvania
- NIH/National Institute (AG010124)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- temporal lobe epilepsy, drug-resistant epilepsy, cognitive impairment, Alzheimer's disease, tau hyperphosphorylation, stress kinases, c-Jun N-terminal kinase, PERK, BACE1, executive function, hippocampus, temporal cortex, temporal lobectomy, neurodegeneration
- MeSH terms
- Drug Resistant Epilepsy, Adolescent, Adult, Aged, Aged, 80 and over, Alzheimer Disease, Autopsy, Child, Child, Preschool, Epilepsy, Temporal Lobe, Female, Hippocampus, Humans, Male, Middle Aged, Peptide Fragments, Temporal Lobe, Case-Control Studies, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, Neurosurgical Procedures, eIF-2 Kinase, JNK Mitogen-Activated Protein Kinases, Young Adult, Plaque, Amyloid, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
