The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Zika virus-associated neurological disorders: a review
Open accessAbstract
Zika virus, an arbovirus transmitted by mosquitoes of the Aedes species, is now rapidly disseminating throughout the Americas and the ongoing Brazilian outbreak is the largest Zika virus epidemic so far described. In addition to being associated with a non-specific acute febrile illness, a number of neurological manifestations, mainly microcephaly and Guillain-Barré syndrome, have been associated with infection. These with other rarer neurological conditions suggest that Zika virus, similar to other flaviviruses, is neuropathogenic. The surge of Zika virus-related microcephaly cases in Brazil has received much attention and the role of the virus in this and in other neurological manifestations is growing. Zika virus has been shown to be transmitted perinatally and the virus can be detected in amniotic fluid, placenta and foetus brain tissue. A significant increase in Guillain-Barré syndrome incidence has also been reported during this, as well as in previous outbreaks. More recently, meningoencephalitis and myelitis have also been reported following Zika virus infection. In summary, while preliminary studies have suggested a clear relationship between Zika virus infection and certain neurological conditions, only longitudinal studies in this epidemic, as well as experimental studies either in animal models or in vitro, will help to better understand the role of the virus and the pathogenesis of these disorders. Zika virus is spreading rapidly throughout the Americas. A number of neurological manifestations, in particular microcephaly and Guillain-Barré syndrome, have been associated with infection. Araujo et al. discuss the role of Zika infection in the pathogenesis of these disorders, and highlight the remaining questions and uncertainties.
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Cites
Zika Virus Outbreak on Yap Island, Federated States of Micronesia
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Zika Virus Associated with Microcephaly
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The Brazilian Zika virus strain causes birth defects in experimental models
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Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth
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Cited by
Onorati, M., Li, Z., Liu, F., Sousa, A. M. M., Nakagawa, N., Li, M., Dell’Anno, M. T., Gulden, F. O., Pochareddy, S., Tebbenkamp, A. T. N., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.038 · Cited by 292
Yu, J., Liu, X., Ke, C., Wu, Q., Lu, W., Qin, Z., He, X., Liu, Y., Deng, J., Xu, S., et al. (2017) · Viruses · doi:10.3390/v9070165 · Cited by 38
Overview on the Current Status of Zika Virus Pathogenesis and Animal Related Research
Pawitwar, S. S., Dhar, S., Tiwari, S., Ojha, C. R., Lapierre, J., Martins, K., Rodzinski, A., Parira, T., Paudel, I., Li, J., et al. (2017) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-017-9743-8 · Cited by 30
Self-citation
Metadata
- Authors
- Araujo, A. Q. C., Silva, M. T. T., & Araujo, A. P. Q. C.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-06-29
- Volume
- 139
- Issue
- 8
- Pages
- 2122-2130
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2466122204
- Cited by
- 406
- References
- 48
- FWCI
- 45.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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