Cited by 30Mosquito-borne diseases and controlViral Infections and VectorsViral Infections and Outbreaks Research

Overview on the Current Status of Zika Virus Pathogenesis and Animal Related Research

Pawitwar, Shashank S., Dhar, Supurna, Tiwari, Sneham, Ojha, Chet Raj, Lapierre, Jessica, Martins, Kyle, Rodzinski, Alexandra, Parira, Tiyash +6 more·2017·Journal of Neuroimmune Pharmacology

Abstract

There is growing evidence that Zika virus (ZIKV) infection is linked with activation of Guillan-Barré syndrome (GBS) in adults infected with the virus and microcephaly in infants following maternal infection. With the recent outpour in publications by numerous research labs, the association between microcephaly in newborns and ZIKV has become very apparent in which large numbers of viral particles were found in the central nervous tissue of an electively aborted microcephalic ZIKV-infected fetus. However, the underlying related mechanisms remain poorly understood. Thus, development of ZIKV-infected animal models are urgently required. The need to develop drugs and vaccines of high efficacy along with efficient diagnostic tools for ZIKV treatment and management raised the demand for a very selective animal model for exploring ZIKV pathogenesis and related mechanisms. In this review, we describe recent advances in animal models developed for studying ZIKV pathogenesis and evaluating potential interventions against human infection, including during pregnancy. The current research directions and the scientific challenges ahead in developing effective vaccines and therapeutics are also discussed.

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Crossref · 10.1007/s11481-017-9743-8

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126 of 126 references verified0 citation errors · 0 not checkable

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Authors
Pawitwar, S. S., Dhar, S., Tiwari, S., Ojha, C. R., Lapierre, J., Martins, K., Rodzinski, A., Parira, T., Paudel, I., Li, J., Dutta, R. K., Silva, M. R., Kaushik, A., & El-Hage, N.
Affiliations
Florida International University (US)
Venue
Journal of Neuroimmune Pharmacology
Published
2017-04-25
Volume
12
Issue
3
Pages
371-388
ISSN
  • 1557-1890 (ISSN-L)
  • 1557-1904
OpenAlex
W2610096538
Cited by
30
References
126
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 6 · 2018: 8 · 2017: 6
FWCI
0.93
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroimmune Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Drug Abuse (DA036154, DA034547, DA036154-S1)
  • Environmental Research and Education Foundation (ES023779)
  • National Institute of Allergy and Infectious Diseases (AI111210)
  • National Institute of General Medical Sciences (GM055425, GM061347)
  • National Science Foundation (1408063)
  • Florida International University Graduate School Presidential Fellowship
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
Keywords
Zika virus, pathogenesis, animal models, Guillain-Barré syndrome, microcephaly, maternal infection, vaccine development, antiviral agents, pregnancy, neurotropism
MeSH terms
Zika Virus Infection, Animals, Disease Models, Animal, Female, Humans, Microcephaly, Pregnancy

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