Overview on the Current Status of Zika Virus Pathogenesis and Animal Related Research
Abstract
There is growing evidence that Zika virus (ZIKV) infection is linked with activation of Guillan-Barré syndrome (GBS) in adults infected with the virus and microcephaly in infants following maternal infection. With the recent outpour in publications by numerous research labs, the association between microcephaly in newborns and ZIKV has become very apparent in which large numbers of viral particles were found in the central nervous tissue of an electively aborted microcephalic ZIKV-infected fetus. However, the underlying related mechanisms remain poorly understood. Thus, development of ZIKV-infected animal models are urgently required. The need to develop drugs and vaccines of high efficacy along with efficient diagnostic tools for ZIKV treatment and management raised the demand for a very selective animal model for exploring ZIKV pathogenesis and related mechanisms. In this review, we describe recent advances in animal models developed for studying ZIKV pathogenesis and evaluating potential interventions against human infection, including during pregnancy. The current research directions and the scientific challenges ahead in developing effective vaccines and therapeutics are also discussed.
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AG129 and Irf3/5/7 TKO mice have been indicated to be uncommonly available in some research laboratories.
“Furthermore, AG129 and Irf3/5/7 TKO mice has been indicated to be uncommonly available in some research laboratories [33, 34].”
From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [33]
A limitation of AG129 mice is their inability to develop vaccines or drugs that depend on the intact interferon pathway.
“However, the limitation of AG129 mice is unable to develop the vaccine or drug that is dependent on the intact interferon pathway [33].”
From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [33]
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Szaba, F. M., Tighe, M., Kummer, L. W., Lanzer, K. G., Ward, J. M., Lanthier, P., Kim, I.-J., Kuki, A., Blackman, M. A., Thomas, S. J., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006994 · Cited by 97 · see citing works
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- Authors
- Pawitwar, S. S., Dhar, S., Tiwari, S., Ojha, C. R., Lapierre, J., Martins, K., Rodzinski, A., Parira, T., Paudel, I., Li, J., Dutta, R. K., Silva, M. R., Kaushik, A., & El-Hage, N.
- Affiliations
- Florida International University (US)
- ORCID
- Venue
- Journal of Neuroimmune Pharmacology
- Published
- 2017-04-25
- Volume
- 12
- Issue
- 3
- Pages
- 371-388
- ISSN
- 1557-1890 (ISSN-L)
- 1557-1904
- OpenAlex
- W2610096538
- Cited by
- 30
- References
- 126
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 6 · 2018: 8 · 2017: 6
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Neuroimmune Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA036154, DA034547, DA036154-S1)
- Environmental Research and Education Foundation (ES023779)
- National Institute of Allergy and Infectious Diseases (AI111210)
- National Institute of General Medical Sciences (GM055425, GM061347)
- National Science Foundation (1408063)
- Florida International University Graduate School Presidential Fellowship
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Keywords
- Zika virus, pathogenesis, animal models, Guillain-Barré syndrome, microcephaly, maternal infection, vaccine development, antiviral agents, pregnancy, neurotropism
- MeSH terms
- Zika Virus Infection, Animals, Disease Models, Animal, Female, Humans, Microcephaly, Pregnancy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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