The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons
Open accessAbstract
Neuropathic pain encompasses a diverse array of clinical entities affecting 7–10% of the population, which is challenging to adequately treat. Several promising therapeutics derived from molecular discoveries in animal models of neuropathic pain have failed to translate following unsuccessful clinical trials suggesting the possibility of important cellular-level and molecular differences between animals and humans. Establishing the extent of potential differences between laboratory animals and humans, through direct study of human tissues and/or cells, is likely important in facilitating translation of preclinical discoveries to meaningful treatments. Patch-clamp electrophysiology and RNA-sequencing was performed on dorsal root ganglia taken from patients with variable presence of radicular/neuropathic pain. Findings establish that spontaneous action potential generation in dorsal root ganglion neurons is associated with radicular/neuropathic pain and radiographic nerve root compression. Transcriptome analysis suggests presence of sex-specific differences and reveals gene modules and signalling pathways in immune response and neuronal plasticity related to radicular/neuropathic pain that may suggest therapeutic avenues and that has the potential to predict neuropathic pain in future cohorts.
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Self-citationSpatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors
Tavares-Ferreira, D., Shiers, S., Ray, P. R., Wangzhou, A., Jeevakumar, V., Sankaranarayanan, I., Cervantes, A. M., Reese, J. C., Chamessian, A., Copits, B. A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abj8186 · Cited by 451
Self-citationChallenges of neuropathic pain: focus on diabetic neuropathy
Rosenberger, D. C., Blechschmidt, V., Timmerman, H., Wolff, A., & Treede, R.-D. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-020-02145-7 · Cited by 325
Metadata
- Authors
- North, R. Y., Li, Y., Ray, P., Rhines, L. D., Tatsui, C. E., Rao, G., Johansson, C. A., Zhang, H., Kim, Y. H., Zhang, B., Dussor, G., Kim, T. H., Price, T. J., & Dougherty, P. M.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-03-19
- Volume
- 142
- Issue
- 5
- Pages
- 1215-1226
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2923498555
- Cited by
- 282
- References
- 35
- FWCI
- 19.86
- Type
- journal article
- Language
- en
- Open access
- green
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- North, R. Y., Li, Y., Ray, P., Rhines, L. D., Tatsui, C. E., Rao, G., Johansson, C. A., Zhang, H., Kim, Y. H., Zhang, B., Dussor, G., Kim, T. H., Price, T. J., & Dougherty, P. M. (2019). Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons. Brain. https://doi.org/10.1093/brain/awz063
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