Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols
Abstract
Our recent studies have shown that polyphenols present in green tea (GTP) possess significant antigenotoxic activity and afford protection against polycyclic aromatic hydrocarbon-induced skin tumor initiation in mice. In this study we assessed the effect of oral feeding and topical application of GTP on ultraviolet B (UVB) radiation-induced skin carcinogenesis in female SKH-1 hairless mice. Chronic oral feeding of GTP (0.1%, w/v) in drinking water resulted in significantly (P less than 0.01) lower tumor yield (percent of animals with tumors and number of tumors per mouse) and extended TDT50 (P less than 0.05), as compared to animals receiving normal drinking water. Topical application of GTP before UVB irradiation also afforded protection against photocarcinogenesis; however, the protective response was lower than that observed by oral feeding of GTP in drinking water. These results, in conjunction with our prior publications, suggest that consumption of green tea may reduce the risk of some forms of human cancer induced by both physical and chemical environmental carcinogens.
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Tea polyphenols, specifically epigallocatechin-3-gallate, have anti-inflammatory and anticarcinogenic effects and can inhibit collagenase activity.
“Aside from the AO functions, tea polyphenols, specifically epigallocatechin-3gallate, also have anti-inflammatory and anticarcinogenic effects (112,117) and can inhibit collagenase activity.”
From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [117]
Green tea polyphenols protect against photocarcinogenesis.
“| (epicatechin-3-gallate), | from tea | Photocarcinogenesis | | + | (117-119) |”
From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [117]
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- Authors
- Wang, Z. Y., Agarwal, R., Bickers, D. R., & Mukhtar, H.
- Affiliations
- University Hospitals of Cleveland (US)
- Corresponding author
- Mukhtar, Hasan
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1991
- Volume
- 12
- Issue
- 8
- Pages
- 1527-1530
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W1980429742
- Cited by
- 217
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 10 · 2013: 11 · 2012: 5
- FWCI
- 12.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carcinogenesis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01es001900-24)
- National Institute of Environmental Health Sciences (ES-1900)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR039750, P30 AR39750)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- green tea polyphenols, UV-B radiation, photocarcinogenesis, skin carcinogenesis, SKH-1 mice, topical application, oral feeding, antigenotoxicity, polycyclic aromatic hydrocarbons, tumor latency, chemoprevention
- MeSH terms
- Animals, Female, Mice, Hairless, Neoplasms, Radiation-Induced, Phenols, Skin Neoplasms, Tea, Mice
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