CoChat
Sign Up
Cited by 262Skin Protection and AgingSirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant Activities

Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice☆☆Part of this work was conducted at the Department of Dermatology, Case Western Reserve University and the Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106.

Afaq, Farrukh, Adhami, Vaqar Mustafa, Ahmad, Nihal·2003·Toxicology and Applied Pharmacology
DOI 10.1016/s0041-008x(02)00014-5
Open this paper in CoChat — free account

Abstract

Nonmelanoma skin cancer is the most common cancer among humans and solar UV radiation, particularly its UVB component (290-320 nm), is its major cause. One way to reduce the occurrence of the cancer is via the use of substances (often antioxidants) termed "photochemopreventive agents". Resveratrol (trans-3,4',5-trihydroxystilbene), a phytoalexin found in grapes, nuts, fruits, and red wine, is a potent antioxidant with strong anti-inflammatory and antiproliferative properties. This study was designed to examine whether resveratrol possesses the potential to ameliorate the damages caused by short-term UVB exposure to mouse skin. Single topical application of resveratrol (25 micromol/0.2 ml acetone per mouse) to SKH-1 hairless mice was found to result in significant inhibition of UVB (180 mJ/cm(2))-mediated increase in bifold skin thickness and skin edema. The resveratrol treatment to mouse skin was also found to result in significant inhibition of UVB-mediated induction of cyclooxygenase and ornithine decarboxylase (ODC) enzyme activities and protein expression of ODC, which are well-established markers for tumor promotion. We also observed that resveratrol inhibits UVB-mediated increased level of lipid peroxidation, a marker of oxidative stress. Taken together, our results suggest that resveratrol may afford substantial protection against the damages caused by UVB exposure, and these protective effects may be mediated via its antioxidant properties.

Integrity signals

Registry

Crossref · 10.1016/s0041-008x(02)00014-5

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Resveratrol protects against edema.

    “| Resveratrol | Skin and seeds of | Edema | | + | (103) |”

    From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [103]

  • A single application of resveratrol on hairless mice skin before UVB radiation inhibited skin edema, cyclooxygenase, ornithine decarboxylase induction, and lipid peroxidation.

    “A single application of resveratrol on hairless mice's skin before exposure to UVB radiation led to the inhibition of skin edema, cyclooxygenase, and ornithine decarboxylase induction and lipid peroxidation in the skin [4, 76].”

    From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [76]

Cites

Flagged first, then by citations

1 of the 62 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Afaq, F., Adhami, V. M., & Ahmad, N.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
Ahmad, Nihal
ORCID
Venue
Toxicology and Applied Pharmacology
Publisher
Elsevier BV
Published
2003-01
Volume
186
Issue
1
Pages
28-37
ISSN
0041-008X (ISSN-L)
DOI
10.1016/s0041-008x(02)00014-5
OpenAlex
W1579832894
Cited by
262
References
62
Citations by year
2026: 1 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 8 · 2019: 10 · 2018: 16 · 2017: 17 · 2016: 6 · 2015: 18 · 2014: 14 · 2013: 7 · 2012: 18
FWCI
13.75
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Toxicology and Applied Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
resveratrol, UV-B radiation, non-melanoma skin cancer, SKH-1 mice, topical application, cyclooxygenase, ornithine decarboxylase, lipid peroxidation, oxidative stress, antioxidants, skin edema, tumor promotion
MeSH terms
Resveratrol, Administration, Topical, Animals, Antioxidants, Female, Hydrogen Peroxide, Mice, Hairless, Prostaglandin-Endoperoxide Synthases, Radiation Injuries, Experimental, Skin, Stilbenes, Ultraviolet Rays, Lipid Peroxidation, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review