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Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin
Abstract
A green tea polyphenol fraction was evaluated for its ability to inhibit tumor initiation by polycyclic aromatic hydrocarbons and tumor promotion by a phorbol ester in the skin of CD-1 mice. Topical application of the green tea polyphenol fraction inhibited benzo[a]pyrene- and 7,12-dimethylbenz[a]-anthracene-induced tumor initiation as well as 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion. Topical application of the green tea polyphenol fraction also inhibited TPA-induced inflammation, ornithine decarboxylase activity, hyperplasia and hydrogen peroxide formation. Studies with individual polyphenolic compounds in green tea indicated that topical application of (-)-epigallocatechin gallate, (-)-epigallocatechin and (-)-epicatechin gallate inhibited TPA-induced inflammation in mouse epidermis.
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Cited by
Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085
Tannins and Human Health: A Review
Chung, K.-T., Wong, T. Y., Wei, C.-I., Huang, Y.-W., & Lin, Y. (1998) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408699891274273 · Cited by 1,996
Surh, Y.-J. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s1383-5742(99)00057-5 · Cited by 633
Cutaneous photodamage, oxidative stress, and topical antioxidant protection
Pinnell, S. R. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.16 · Cited by 544
Cancer Prevention With Natural Compounds
Gullett, N. P., Ruhul Amin, A. R. M., Bayraktar, S., Pezzuto, J. M., Shin, D. M., Khuri, F. R., Aggarwal, B. B., Surh, Y.-J., & Kucuk, O. (2010) · Seminars in Oncology · doi:10.1053/j.seminoncol.2010.06.014 · Cited by 485
Metadata
- Authors
- Huang, M.-T., Ho, C.-T., Wang, Z. Y., Ferraro, T., Finnegan-Olive, T., Lou, Y.-R., Mitchell, J. M., Laskin, J. D., Newmark, H., Yang, C. S., & Conney, A. H.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1992
- Volume
- 13
- Issue
- 6
- Pages
- 947-954
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W1986093516
- Cited by
- 207
- References
- 0
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huang, M.-T., Ho, C.-T., Wang, Z. Y., Ferraro, T., Finnegan-Olive, T., Lou, Y.-R., Mitchell, J. M., Laskin, J. D., Newmark, H., Yang, C. S., & Conney, A. H. (1992). Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis. https://doi.org/10.1093/carcin/13.6.947
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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