The DOI matches its Crossref record.
Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA
Abstract
The endogenous production of oxidative damage in DNA by free radicals released as a by-product of respiration is a likely cause of mutations which, if they occur in appropriate genes, may lead to cancer. Using an endonuclease specific for oxidized pyrimidines, in conjunction with the highly sensitive method of single cell gel electrophoresis, we have detected significant oxidative damage in untreated, freshly isolated lymphocytes from normal, healthy individuals.
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Citations
Cited by
Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing
Tice, R. R., Agurell, E., Anderson, D., Burlinson, B., Hartmann, A., Kobayashi, H., Miyamae, Y., Rojas, E., Ryu, J.-C., & Sasaki, Y. F. (2000) · Environmental and Molecular Mutagenesis · doi:10.1002/(sici)1098-2280(2000)35:3<206::aid-em8>3.0.co;2-j · Cited by 4,860
The Comet Assay for DNA Damage and Repair: Principles, Applications, and Limitations
Collins, A. R. (2004) · Molecular Biotechnology · doi:10.1385/mb:26:3:249 · Cited by 2,892
Self-citationWISEMAN, H., & HALLIWELL, B. (1996) · Biochemical Journal · doi:10.1042/bj3130017 · Cited by 2,345
Free radicals, oxidative stress, and antioxidants in human health and disease
Aruoma, O. I. (1998) · Journal of the American Oil Chemists' Society · doi:10.1007/s11746-998-0032-9 · Cited by 1,682
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
Parrinello, S., Samper, E., Krtolica, A., Goldstein, J., Melov, S., & Campisi, J. (2003) · Nature Cell Biology · doi:10.1038/ncb1024 · Cited by 1,116
Metadata
- Authors
- Collins, A. R., Duthie, S. J., & Dobson, V. L.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1993
- Volume
- 14
- Issue
- 9
- Pages
- 1733-1735
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W1968499584
- Cited by
- 828
- References
- 0
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Collins, A. R., Duthie, S. J., & Dobson, V. L. (1993). Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis. https://doi.org/10.1093/carcin/14.9.1733
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
