p53 is dispensable for UV-induced cell cycle arrest at late G1 in mammalian cells

Al-Mohanna, Mai A.; Al-Khodairy, Fahad M.; Krezolek, Zbigniew; Bertilsson, Per-Anders; Al-Houssein, Khalid A.; Aboussekhra, Abdelilah

doi:10.1093/carcin/22.4.573

Cited by 30Cancer-related Molecular PathwaysDNA Repair MechanismsCell death mechanisms and regulation

p53 is dispensable for UV-induced cell cycle arrest at late G1 in mammalian cells

Al-Mohanna, Mai A., Al-Khodairy, Fahad M., Krezolek, Zbigniew, Bertilsson, Per-Anders, Al-Houssein, Khalid A., Aboussekhra, Abdelilah·2001·Carcinogenesis

DOI 10.1093/carcin/22.4.573

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Abstract

Genotoxic agents, including gamma-rays and UV light, induce transient arrest at different phases of the cell cycle. These arrests are required for efficient repair of DNA lesions, and employ several factors, including the product of the tumor suppressor gene p53 that plays a central role in the cellular response to DNA damage. p53 protein has a major function in the gamma-ray-induced cell cycle delay in G(1) phase. However, it remains uncertain as to whether p53 is also involved in the UV-mediated G(1) delay. This report provides evidence that p53 is not involved in UV-induced cellular growth arrest in late G(1) phase. This has been demonstrated in HeLa cells synchronized at the G(1)/S border by aphidicolin, followed by UV exposure. Interestingly, the length of this p53-independent G(1) arrest has been shown to be UV dose-dependent. Similar results were also obtained with other p53-deficient cell lines, including human promyelocytic leukemia HL-60 and mouse p53 knock-out cells. As expected, all of these cell lines were defective in gamma-ray-induced cell growth arrest at late G(1). Moreover, it is shown that in addition to cell cycle arrest, HL-60 cells undergo apoptosis in G(1) phase in response to UV light but not to gamma-rays. Together, these findings indicate that p53- compromised cells have a differential response following exposure to ionizing radiation or UV light.

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UVR can cause cell cycle arrest both at G1 and G2 phases of cell cycle.
“Previous studies have shown that UVR can cause cell cycle arrest both at G1 [63] and G2 phases [64] of cell cycle.”
From The Effect of Lycopene Preexposure on UV‐B‐Irradiated Human Keratinocytes (2016) · cites this paper as [63]

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Authors: Al-Mohanna, M. A., Al-Khodairy, F. M., Krezolek, Z., Bertilsson, P.-A., Al-Houssein, K. A., & Aboussekhra, A.
Corresponding author: Aboussekhra, Abdelilah
ORCID: Al-Khodairy, Fahad M.
Aboussekhra, Abdelilah
Venue: Carcinogenesis
Publisher: Oxford University Press (OUP)
Published: 2001-04
Volume: 22
Issue: 4
Pages: 573-578
ISSN: 0143-3334 (ISSN-L)
1460-2180
DOI: 10.1093/carcin/22.4.573
OpenAlex: W2149316054
Cited by: 30
References: 42
Citations by year: 2024: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI: 0.59
Type: journal article
Language: en
Open access: closed
Locations: Carcinogenesis (publishedVersion)
PubMed (publishedVersion)
Funders: King Faisal Specialist Hospital and Research Centre
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: p53, DNA damage response, p53-deficient cells, HL-60 cells, HeLa cells, UV-induced apoptosis, ionizing radiation response, UV dose dependence
MeSH terms: Animals, Cell Cycle, Cell Line, Dose-Response Relationship, Radiation, Flow Cytometry, Gamma Rays, HeLa Cells, Humans, Light, Time Factors, Ultraviolet Rays, Tumor Suppressor Protein p53, G1 Phase, Apoptosis, Mice, Knockout, HL-60 Cells, Mice, DNA Fragmentation

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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p53 is dispensable for UV-induced cell cycle arrest at late G1 in mammalian cells

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