Caffeic and ferulic acid as blockers of nitrosamine formation

Kuenzig, W.; Chau, J.; Norkus, E.; Holowaschenko, H.; Newmark, H.; Mergens, W.; Conney, A.H.

doi:10.1093/carcin/5.3.309

Cited by 121Phytochemicals and Antioxidant ActivitiesCarcinogens and Genotoxicity AssessmentAntioxidant Activity and Oxidative Stress

Caffeic and ferulic acid as blockers of nitrosamine formation

Kuenzig, W., Chau, J., Norkus, E., Holowaschenko, H., Newmark, H., Mergens, W., Conney, A.H.·1984·Carcinogenesis

DOI 10.1093/carcin/5.3.309

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Abstract

Caffeic acid and ferulic acid, which are naturally occurring phenols present in a wide variety of plants, were examined for their ability to react with nitrite in vitro and to inhibit nitrosamine formation in vivo. Their activities were compared with other phenols (butylated hydroxyanisole and Trolox) and with a non-phenolic polyhydroxylated compound, glycerol guaiacolate. In simulated gastric fluid, caffeic acid and ferulic acid reacted rapidly and completely with an equimolar quantity of sodium nitrite. In rats receiving aminopyrine and nitrite, caffeic acid and ferulic acid blocked the elevation of serum N-nitrosodimethylamine (NDMA) levels and the serum glutamic pyruvic transaminase levels associated with hepatotoxicity. Neither phenol had any effect on serum levels of NDMA in rats treated with NDMA. In both the in vitro (reaction with nitrite) and in vivo (inhibition of hepatotoxicity) systems, caffeic acid was more effective than ferulic acid. Butylated hydroxyanisole and Trolox were partially effective, and glycerol guaiacolate was inactive. The results of this study suggest that dietary caffeic acid and ferulic acid may play a role in the body's defense against carcinogenesis by inhibiting the formation of N-nitroso compounds.

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The reduction of caffeic and ferulic acids may lower their protective effects against carcinogenesis and mammalian tumors.
“This may lower their protective effects against carcinogenesis and even mammalian tumors (Kuenzig et al., 1984;Baskaran et al., 2010).”
From RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize (2012) · cites this paper as Kuenzig et al., 1984
This may lower their protective effects against carcinogenesis and mammalian tumor formation.
“This may lower their protective effects against carcinogenesis and mammalian tumor formation [69,70].”
From Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize (2014) · cites this paper as [69]

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Authors: Kuenzig, W., Chau, J., Norkus, E., Holowaschenko, H., Newmark, H., Mergens, W., & Conney, A. H.
Venue: Carcinogenesis
Publisher: Oxford University Press (OUP)
Published: 1984
Volume: 5
Issue: 3
Pages: 309-313
ISSN: 0143-3334 (ISSN-L)
1460-2180
DOI: 10.1093/carcin/5.3.309
OpenAlex: W2044415061
Cited by: 120
References: 0
Citations by year: 2026: 3 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 4
FWCI: 3.55
Type: journal article
Language: en
Open access: closed
Locations: Carcinogenesis (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords: caffeic acid, ferulic acid, nitrosamine formation, nitrosation inhibition, nitrite, N-nitrosodimethylamine, hepatotoxicity, alanine aminotransferase, aminopyrine, butylated hydroxyanisole, Trolox, carcinogenesis prevention, simulated gastric fluid
MeSH terms: Alanine Transaminase, Aminopyrine, Animals, Caffeic Acids, Cholagogues and Choleretics, Cinnamates, Coumaric Acids, Gastric Juice, Kinetics, Male, Mutagenicity Tests, Mutation, Nitrites, Nitrosamines, Phenols, Rats, Inbred Strains, Salmonella typhimurium, Sodium Nitrite, Rats

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Caffeic and ferulic acid as blockers of nitrosamine formation

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