The DOI matches its Crossref record.
Caffeic and ferulic acid as blockers of nitrosamine formation
Abstract
Caffeic acid and ferulic acid, which are naturally occurring phenols present in a wide variety of plants, were examined for their ability to react with nitrite in vitro and to inhibit nitrosamine formation in vivo. Their activities were compared with other phenols (butylated hydroxyanisole and Trolox) and with a non-phenolic polyhydroxylated compound, glycerol guaiacolate. In simulated gastric fluid, caffeic acid and ferulic acid reacted rapidly and completely with an equimolar quantity of sodium nitrite. In rats receiving aminopyrine and nitrite, caffeic acid and ferulic acid blocked the elevation of serum N-nitrosodimethylamine (NDMA) levels and the serum glutamic pyruvic transaminase levels associated with hepatotoxicity. Neither phenol had any effect on serum levels of NDMA in rats treated with NDMA. In both the in vitro (reaction with nitrite) and in vivo (inhibition of hepatotoxicity) systems, caffeic acid was more effective than ferulic acid. Butylated hydroxyanisole and Trolox were partially effective, and glycerol guaiacolate was inactive. The results of this study suggest that dietary caffeic acid and ferulic acid may play a role in the body's defense against carcinogenesis by inhibiting the formation of N-nitroso compounds.
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“This may lower their protective effects against carcinogenesis and even mammalian tumors (Kuenzig et al., 1984;Baskaran et al., 2010).”
From RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize (2012) · cites this paper as Kuenzig et al., 1984
In the citing paper
“This may lower their protective effects against carcinogenesis and mammalian tumor formation [69,70].”
From Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize (2014) · cites this paper as [69]
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Items 101–121 of 121
ICHIHARA, T., MIYASHITA, K., KAWABE, M., IMAIDA, K., ASAMOTO, M., OGISO, T., TAMANO, S., HIROSE, M., & SHIRAI, T. (2005) · The Journal of Toxicological Sciences · doi:10.2131/jts.30.1 · Cited by 3
Wheeler, G. C., & Wheeler, J. (1990) · Lincoln (University of Nebraska) · doi:10.5281/zenodo.25115 · Cited by 3
Screening of Effective Components from Kale to Inhibit N - Nitrosodimethylamine Formation
정미자, 이수정, 최선영, & 성낙주 (2003) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2003.32.2.223 · Cited by 3
Effect of butylated hydroxyanisole on in vitro and in vivo nitrosation of dibutylamine
Airoldi, L., Pastorelli, R., Macrí, A., et al. (1987) · Toxicology · doi:10.1016/0300-483x(87)90011-4 · Cited by 3
Simultaneous C- and N-nitrosation of synephrine. A kinetic study
Fernández‐Liencres, M. P., Carazo, F., Cabeza, M. C., et al. (1993) · Journal of the Chemical Society Perkin Transactions 2 · doi:10.1039/p29930002265 · Cited by 3
Nardin, T., Franceschini, J., Martinelli, F., Franciosi, E., & Larcher, R. (2025) · Molecules · doi:10.3390/molecules30204107 · Cited by 4
“Kuenzig et al. [32] first demonstrated that phenolic acids such as caffeic and ferulic acid can effectively block nitrosamine formation, while Honikel extensively reviewed the inhibitory action of ascorbate and erythorbate in curing processes.”
Food phenolics and cancer chemoprevention
Shahidi, F. (2004) · Elsevier eBooks · doi:10.1533/9781855739017.4.669 · Cited by 2
The Chemistry of Coffee Furans and Hydroxycinnamates under Simulated Gastric Conditions
Napolitano, A., & Panzella, L. (2014) · Coffee in Health and Disease Prevention · doi:10.1016/b978-0-12-409517-5.00097-8 · Cited by 2
Divakaran, S. A., & Anitha, C. T. (2021) · Journal of Applied and Natural Science · doi:10.31018/jans.v13i3.2732 · Cited by 2
“As an antioxidant, FA plays a major role in the body's defence against carcinogenesis by inhibiting the formation of N-nitroso compounds (Kuenzig et al., 1984; Lee et al., 2009; Aarabi et al., 2016).”
BackgroundChemoprevention of Chemical Carcinogenesis and Human Cancer
Morse, M. A., & Stoner, G. D. (2005) · CRC Press eBooks · doi:10.1201/9780203503430.ch21 · Cited by 2
Clinical Stabilization in Parkinson´s Disease: The Multi-Target Treatment Description and Results
Nakanishi, T., & Tamai, I. (2019) · doi:10.17303/jnnd.2016.3.102 · Cited by 1
Inhibition of in Vivo Mutagenicity by Maillard Reaction Products and Coffee
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(2013) · CRC Press eBooks · doi:10.1201/b13973-30
(2008) · CRC Press eBooks · doi:10.1201/9780849378812.ch2
(2015) · CRC Press eBooks · doi:10.1201/b18962-3
Rani, U., Lather, P., Dhingra, D., et al. (2026) · Cytotechnology · doi:10.1007/s10616-026-00932-w
Shao, X., Pan, Q., Xiao, Q., Chen, C., Xu, B., & Li, P. (2026) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2026.111760
Sirvins, C. (2024) · theses.fr (ABES) · doi:10.70675/578552b1z332ez4b45za97dz5a97925cb761
Sirvins, C., Goupy, P., & Dufour, C. (2026) · Current Research in Food Science · doi:10.1016/j.crfs.2026.101581
Metadata
- Authors
- Kuenzig, W., Chau, J., Norkus, E., Holowaschenko, H., Newmark, H., Mergens, W., & Conney, A. H.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1984
- Volume
- 5
- Issue
- 3
- Pages
- 309-313
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2044415061
- Cited by
- 120
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 4
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carcinogenesis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- caffeic acid, ferulic acid, nitrosamine formation, nitrosation inhibition, nitrite, N-nitrosodimethylamine, hepatotoxicity, alanine aminotransferase, aminopyrine, butylated hydroxyanisole, Trolox, carcinogenesis prevention, simulated gastric fluid
- MeSH terms
- Alanine Transaminase, Aminopyrine, Animals, Caffeic Acids, Cholagogues and Choleretics, Cinnamates, Coumaric Acids, Gastric Juice, Kinetics, Male, Mutagenicity Tests, Mutation, Nitrites, Nitrosamines, Phenols, Rats, Inbred Strains, Salmonella typhimurium, Sodium Nitrite, Rats
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