LACK OF COMBINATION HEPATOCARCINOGENICITY OF HARMAN, NORHARMAN AND AMITROLE WHEN GIVEN WITH NaNO2 IN THE RAT
Open accessAbstract
N-nitrosocompounds, which induce cancers in various organs, may be formed endogenously with intake of amino compounds such as secondary amines and sodium nitrite (NaNO(2)) in combination. The present study was performed to investigate whether three amino compounds, 1-methyl-9H-pyrido[3,4-b]indole (harman), 9H-pyrido[3,4-b]indole (norharman) and 2-amino-1,3,4-triazole (amitrole), might be converted in vivo to compounds capable of promoting hepatocarcinogenesis when given with NaNO(2). However, in an 8-week model, no modifying potential was evident in terms of numbers and areas of putative preneoplastic glutathione S-transferase placental form (GST-P)-positive foci in any of the groups receiving paired treatments. These results demonstrate that combinations of harman, norharman and amitrole with NaNO(2) lack promoting effects for liver carcinogenesis in our medium-term bioassay system.
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Sodium nitrite does not significantly contribute to cellular transformation.
“However, studies also indicated that sodium nitrite does not significantly contribute to cellular transformation [272, 273].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [272]
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- Authors
- ICHIHARA, T., MIYASHITA, K., KAWABE, M., IMAIDA, K., ASAMOTO, M., OGISO, T., TAMANO, S., HIROSE, M., & SHIRAI, T.
- Affiliations
- Nagoya City University (JP)
- DIMS Institute of Medical Science
- Kagawa University (JP)
- National Institute of Health Sciences (LK)
- Venue
- The Journal of Toxicological Sciences
- Publisher
- Japanese Society of Toxicology
- Published
- 2005
- Volume
- 30
- Issue
- 1
- Pages
- 1-6
- ISSN
- 0388-1350 (ISSN-L)
- 1880-3989
- OpenAlex
- W1970408217
- Cited by
- 3
- References
- 33
- Citations by year
- 2012: 1
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Toxicological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Synthesis and bioactivity of alkaloids
- Keywords
- hepatocarcinogenesis, sodium nitrite, harman, norharman, 3-amino-1,2,4-triazole, N-nitrosation, glutathione S-transferase placental, preneoplastic foci, secondary amines
- MeSH terms
- Amitrole, Animals, Carbolines, Harmine, Liver Neoplasms, Experimental, Male, Rats, Inbred F344, Sodium Nitrite, Weight Gain, Rats
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