Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00062-3 · Cited by 1,819

In situ detection of fragmented DNA (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note*1

Kraupp, B. G., Ruttkay-Nedecký, B., Koudelka, H., Bukowska, K., Bursch, W., & Schulte‐Hermann, R. (1995) · Hepatology · doi:10.1002/hep.1840210534 · Cited by 1,223

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

Zhang, Y., Lee, F. Y., Barrera, G., Lee, H., Vales, C., Gonzalez, F. J., Willson, T. M., & Edwards, P. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506982103 · Cited by 974

Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration

Huang, W., Ma, K., Zhang, J., Qatanani, M., Cuvillier, J., Liu, J., Dong, B., Huang, X., & Moore, D. D. (2006) · Science · doi:10.1126/science.1121435 · Cited by 645

Endocrine functions of bile acids

Houten, S. M., 渡辺, 光., & Auwerx, J. H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601049 · Cited by 595

The Farnesoid X Receptor Modulates Adiposity and Peripheral Insulin Sensitivity in Mice

Cariou, B., van Harmelen, K., Durán-Sandoval, D., van Dijk, T. H., Grefhorst, A., Abdelkarim, M., Caron, S., Torpier, G., Fruchart, J., Gonzalez, F. J., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510258200 · Cited by 546

Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas

Faubion, W. A., Guicciardi, M. E., Miyoshi, H., Bronk, S. F., Roberts, P. J., Svingen, P. A., Kaufmann, S. H., & Gores, G. J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4765 · Cited by 539

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

Fiorucci, S., Antonelli, E., Rizzo, G., Renga, B., Mencarelli, A., Riccardi, L., Orlandi, S., Pellicciari, R., & Morelli, A. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.001 · Cited by 472

Activation of hepatic stellate cells - a key issue in liver fibrosis

Reeves, H. L. (2002) · Frontiers in bioscience · doi:10.2741/reeves · Cited by 421

Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.

Peraino, C., Fry, R. J., & Staffeldt, E. F. (1971) · PubMed · Cited by 410

The gut–liver axis in hepatocarcinoma: a focus on the nuclear receptor FXR and the enterokine FGF19

Piglionica, M., Cariello, M., & Moschetta, A. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.08.005 · Cited by 30

Carcinogenic and anticancer activities of microbiota-derived secondary bile acids

Kouhzad, M., Götz, F., Navidifar, T., Taki, E., Ghamari, M., Mohammadzadeh, R., Seyedolmohadesin, M., & Bostanghadiri, N. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1514872 · Cited by 31

Disordered farnesoid X receptor signaling is associated with liver carcinogenesis in Abcb11 ‐deficient mice

Wang, L., Luo, Q., Zeng, S., Lou, Y., Li, X., Hu, M., Lu, L., & Liu, Z. (2021) · The Journal of Pathology · doi:10.1002/path.5780 · Cited by 28

Farnesoid X receptor inhibits LNcaP cell proliferation via the upregulation of PTEN

Liu, J., Tong, S., Wang, X., & Qu, L. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1894 · Cited by 27

Models to Study Liver Regeneration

Pritchard, M. T., & Apte, U. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420128-6.00002-6 · Cited by 27

Bile acids and their receptors in hepatic immunity

Fiorucci, S., Marchianò, S., Distrutti, E., & Biagioli, M. (2025) · Liver Research · doi:10.1016/j.livres.2025.01.005 · Cited by 31

Genotypes and different clinical variants between children and adults in progressive familial intrahepatic cholestasis: a state-of-the-art review

Vitale, G., Sciveres, M., Mandato, C., D’Adamo, P., & Giorgio, A. D. (2025) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-025-03599-2 · Cited by 26

Current Landscape and Evolving Therapies for Primary Biliary Cholangitis

Fiorucci, S., Urbani, G., Giorgio, C. D., Biagioli, M., & Distrutti, E. (2024) · Cells · doi:10.3390/cells13181580 · Cited by 28

Helicobacter hepaticus –Induced Liver Tumor Promotion Is Associated with Increased Serum Bile Acid and a Persistent Microbial-Induced Immune Response

García, A., Zeng, Y., Muthupalani, S., Ge, Z., Potter, A. F., Mobley, M. W., Boussahmain, C., Feng, Y., Wishnok, J. S., & Fox, J. G. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1975 · Cited by 26

Physical exercise plays a role in rebalancing the bile acids of enterohepatic axis in non‐alcoholic fatty liver disease

Zhang, M., Xiao, B., Chen, X., Ou, B., & Wang, S. (2023) · Acta Physiologica · doi:10.1111/apha.14065 · Cited by 28

Regulation of the gene encoding the intestinal bile acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2

Ma, L., Jüttner, M., Kullak-Ublick, G. A., & Eloranta, J. J. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00102.2011 · Cited by 25

Abnormal Metabolism in the Progression of Nonalcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Mechanistic Insights to Chemoprevention

Orabi, D., Berger, N. A., & Brown, J. M. (2021) · Cancers · doi:10.3390/cancers13143473 · Cited by 25

The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics study

Yang, G., Jena, P. K., Hu, Y. C., Sheng, L., Chen, S., Slupsky, C. M., Davis, R. R., Tepper, C. G., & Wan, Y. Y. (2023) · Biomarker Research · doi:10.1186/s40364-023-00458-9 · Cited by 23

Microbial transformations of bile acids and their receptors in the regulation of metabolic dysfunction-associated steatotic liver disease

Gao, Y., Lin, J., Ye, C., Guo, S., & Jiang, C. (2023) · Liver Research · doi:10.1016/j.livres.2023.09.002 · Cited by 26

Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes

Teng, Y. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i1.300 · Cited by 26

Bile-ology: from bench to bedside

Jin, L., Fang, Z., Fan, M.-J., & Huang, W. (2019) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1900158 · Cited by 22

Polyphenic trait promotes liver cancer in a model of epigenetic instability in mice

Cassano, M., Offner, S., Planet, E., Piersigilli, A., Jang, S. M., Henry, H., Geuking, M. B., Mooser, C., McCoy, K. D., Macpherson, A. J., et al. (2017) · Hepatology · doi:10.1002/hep.29182 · Cited by 22

Sex Dimorphic Effects of Bile Acid Metabolism in Liver Cancer in Mice

Golonka, R. M., Yeoh, B. S., Saha, P., Tian, Y., Chiang, J. Y. L., Patterson, A. D., Gewirtz, A. T., Joe, B., & Vijay–Kumar, M. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.01.011 · Cited by 24

Chronic Activation of FXR in Transgenic Mice Caused Perinatal Toxicity and Sensitized Mice to Cholesterol Toxicity

Cheng, Q., Inaba, Y., Lu, P., Xu, M., He, J., Zhao, Y., Guo, G. L., Kuruba, R., de la Vega, R., Evans, R. G., et al. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1337 · Cited by 22

Tumor suppressor p53 regulates bile acid homeostasis via small heterodimer partner

Kim, D., & Lee, J. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019678108 · Cited by 20

Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia

Chen, M.-C., Chen, Y., Wang, T.-W., Hsu, H., & Lai, M.-D. (2016) · Oncology Reports · doi:10.3892/or.2016.5011 · Cited by 21

Targeting Farnesoid X Receptor in Tumor and the Tumor Microenvironment: Implication for Therapy

Nenkov, M., Shi, Y. H., Ma, Y., Gaßler, N., & Chen, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010006 · Cited by 23

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Bellafante, E., McIlvride, S., Nikolova, V., Fan, H. M., Manna, L. B., Chambers, J., Machirori, M., Banerjee, A., Murphy, K. G., Martineau, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67968-6 · Cited by 20

The farnesoid X receptor induces fetuin-B gene expression in human hepatocytes

Murakami, T., Walczak, R., Caron, S., Duhem, C., Vidal, V., Darteil, R., & Staels, B. (2007) · Biochemical Journal · doi:10.1042/bj20070658 · Cited by 20

Roles of Bile Acid-Activated Receptors in Monocytes-Macrophages and Dendritic Cells

Jia, H., He, X., Jiang, T., & Kong, F. (2025) · Cells · doi:10.3390/cells14120920 · Cited by 21

Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet

Chun, H. J., Shim, Y. J., & Kwon, Y. H. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108869 · Cited by 19

System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells

Wigger, L., Casals‐Casas, C., Baruchet, M., Trang, B. K., Pradervand, S., Naldi, A., & Desvergne, B. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220894 · Cited by 19

Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis

Trauner, M. A., Gindin, Y., Jiang, Z., Chung, C., Subramanian, G. M., Myers, R. P., Gulamhusein, A. F., Kowdley, K. V., Levy, C., Goodman, Z. D., et al. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.11.004 · Cited by 18

The protective role of hydrophilic tetrahydroxylated bile acids (THBA)

Sheps, J. A., Wang, R., Wang, J., & Ling, V. W. T. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158925 · Cited by 19

Transcriptional Regulation of the Intestinal Nuclear Bile Acid Farnesoid X Receptor (FXR) by the caudal-related Homeobox 2 (CDX2)

Modica, S., Cariello, M., Morgano, A., Groß, I., Vegliante, M. C., Murzilli, S., Salvatore, L., Freund, J., Sabbà, C., & Moschetta, A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.571513 · Cited by 18

Cathepsin V is correlated with the prognosis and tumor microenvironment in liver cancer

Liu, J., Zhang, W., Wang, Z., Wang, Y., Li, T., Wang, Y., Ding, J., & Ning, B. (2023) · Molecular Carcinogenesis · doi:10.1002/mc.23660 · Cited by 17

Cooperative behavior of the nuclear receptor superfamily and its deregulation in prostate cancer

Long, M. D., Thorne, J. L., Russell, J., Battaglia, S., Singh, P. K., Sucheston-Campbell, L. E., & Campbell, M. J. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt334 · Cited by 17

Proteomics for the discovery of nuclear bile acid receptor FXR targets

Gardmo, C., Tamburro, A., Modica, S., & Moschetta, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.03.009 · Cited by 17

Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites

Teske, K. A., Bogart, J. W., Sanchez, L. M., Yu, O. B., Preston, J., Cook, J. M., Silvaggi, N. R., Bikle, D. D., & Arnold, L. A. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.01.002 · Cited by 17

Pathological and therapeutic roles of bile acid metabolism and signaling in hepatocellular carcinoma: Insights from human and mouse studies

Wang, X., Klaassen, C. D., Chen, X., & Zhang, Y. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100073 · Cited by 17

Baohuoside I inhibits FXR signaling pathway to interfere with bile acid homeostasis via targeting ER α degradation

Zhao, Z. Z., Yang, L., Wang, Q.-L., Du, J., Zheng, Z., Jiang, Y., Li, P., & Li, H. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-022-09737-x · Cited by 16

Enhanced expression of farnesoid X receptor in human hepatocellular carcinoma

Kumagai, A., Fukushima, J., Takikawa, H., Fukuda, T., & Fukusato, T. (2013) · Hepatology Research · doi:10.1111/hepr.12047 · Cited by 16

Helicobacter hepaticus Infection Promotes Hepatitis and Preneoplastic Foci in Farnesoid X Receptor (FXR) Deficient Mice

Swennes, A. G., Sheh, A., Parry, N. M., Muthupalani, S., Lertpiriyapong, K., García, A., & Fox, J. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106764 · Cited by 16

Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXRα

Fang, C., Filipp, F. V., & Smith, J. W. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m021733 · Cited by 15

Bile acids in liver and gastrointestinal cancer

Monte, M. J., Fàbrega, L., Romero, M. R., Temprano, Á. G., Kaplowitz, N., García‐Ruiz, C., Marı́n, J. J. G., & Fernández-Checa, J. C. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.09.002 · Cited by 16

Dysregulation and activities of ubiquitin specific peptidase 2b in the pathogenesis of hepatocellular carcinoma.

Nadolny, C., Zhang, X., Chen, Q., Hashmi, S. F., Ali, W., Hemme, C. L., Ahsan, N., Chen, Y., & Deng, R. (2021) · Europe PMC (PubMed Central) · Cited by 15

FXR deficiency in hepatocytes disrupts the bile acid homeostasis and inhibits autophagy to promote liver injury in Schistosoma japonicum-infected mice

Zhang, B., Li, J., Zong, X., Wang, J., Xin, L., Song, H., Zhang, W., Koda, S., Hua, H. M., Zhang, B., et al. (2022) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010651 · Cited by 14

Review article: nuclear receptors and liver disease – current understanding and new therapeutic implications

Elfaki, D., Bjornsson, E. S., & Lindor, K. D. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04104.x · Cited by 14

CAMK2γ antagonizes mTORC1 activation during hepatocarcinogenesis

Meng, Z., Ma, X., Du, J., Wang, X., He, M., Gu, Y., Zhang, J., Han, W., Fang, Z., Gan, X., et al. (2016) · Oncogene · doi:10.1038/onc.2016.400 · Cited by 14

The Microbial Bile Acid Metabolite 3-Oxo-LCA Inhibits Colorectal Cancer Progression

Sun, F., Wang, K., Dong, X., Secaira-Morocho, H., Hui, A., Cai, C., Sze, J., Low, B., Udgata, S., Pasch, C. A., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-3898 · Cited by 17

Gut microbiome and bile acid metabolism in liver disease: Mechanisms, clinical implications, and therapeutic opportunities

Zhou, H., Huang, Y., Chen, C., Song, M., & Hylemon, P. B. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100120 · Cited by 17

C-Terminal Truncated HBx Facilitates Oncogenesis by Modulating Cell Cycle and Glucose Metabolism in FXR-Deficient Hepatocellular Carcinoma

Wu, X., Ni, Z., Song, T., Lv, W., Chen, Y., Huang, D., Xie, Y., Huang, W., & Niu, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065174 · Cited by 13

Uncovering the Gut–Liver Axis Biomarkers for Predicting Metabolic Burden in Mice

Yang, G., Liu, R., Rezaei, S., Liu, X., & Wan, Y. Y. (2023) · Nutrients · doi:10.3390/nu15153406 · Cited by 13

Hepatic gene expression in mouse models of non‐alcoholic fatty liver disease after acute exercise

Piguet, A., Guarino, M., Potaczek, D. P., Garn, H., & Dufour, J. (2019) · Hepatology Research · doi:10.1111/hepr.13323 · Cited by 13

Discovery of 9,11-Seco-Cholesterol Derivatives as Novel FXR Antagonists

Zhou, J.-X., Li, C.-N., Liu, Y., Lin, S., Wang, Y., Xie, C., & Nan, F. (2022) · ACS Omega · doi:10.1021/acsomega.2c01567 · Cited by 12

Activation of farnesoid X receptor attenuates liver injury in systemic lupus erythematosus

Lian, F., Wang, Y., Chen, J., Xu, H., Yang, X., Liang, L., Zhan, Z., Ye, Y., & Chen, M. (2011) · Rheumatology International · doi:10.1007/s00296-011-1874-2 · Cited by 12

Nuclear receptor ligands in therapy of cholestatic liver disease

Sturm, E. (2009) · Frontiers in bioscience · doi:10.2741/3529 · Cited by 12

Cholangiocarcinoma development: The resurgence of bile acids

Maroni, L., Alpini, G. D., & Marzioni, M. (2014) · Hepatology · doi:10.1002/hep.27223 · Cited by 12

The contributions of bacteria metabolites to the development of hepatic encephalopathy

Gilbert, M. C., Setayesh, T., & Wan, Y. Y. (2022) · Liver Research · doi:10.1016/j.livres.2022.11.005 · Cited by 10

Farnesoid X receptor alpha (FXRα) is a critical actor of the development and pathologies of the male reproductive system

Garcia, M., Thirouard, L., Monrose, M., Holota, H., Haze, A. D., Caira, F., Beaudoin, C., & Volle, D. H. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03247-6 · Cited by 11

Genomic and transcriptomic somatic alterations of hepatocellular carcinoma in non-cirrhotic livers

Skidmore, Z. L., Kunisaki, J., Lin, Y., Cotto, K. C., Barnell, E. K., Hundal, J., Krysiak, K., Magrini, V. J., Trani, L., Walker, J., et al. (2022) · Cancer Genetics · doi:10.1016/j.cancergen.2022.04.002 · Cited by 10

Trimethylamine N-oxide ameliorates hepatic damage including reduction of hepatic bile acids and cholesterol in Fxr -null mice

Miyata, M., Takeda, K., Nagira, S., & Sugiura, Y. (2024) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2024.2346765 · Cited by 10

Hepatocellular carcinoma in the context of non-alcoholic steatohepatitis (NASH): recent advances in the pathogenic mechanisms

Lequoy, M., Gigante, E., Couty, J., & Desbois‐Mouthon, C. (2020) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2019-0044 · Cited by 12

Intestinal FXR Activation via Transgenic Chimera or Chemical Agonism Prevents Colitis-Associated and Genetically-Induced Colon Cancer

Cariello, M., Zerlotin, R., Pasculli, E., Piccinin, E., Peres, C., Porru, E., Roda, A., Gadaleta, R. M., & Moschetta, A. (2022) · Cancers · doi:10.3390/cancers14133081 · Cited by 11

Non-Alcoholic Fatty Liver Disease: The Effect of Bile Acids and Farnesoid X Receptor Agonists on Pathophysiology and Treatment

Khalid, Q., Bailey, I., & Patel, V. B. (2015) · Liver Research - Open Journal · doi:10.17140/lroj-1-106 · Cited by 10

Fish oil feeding reverses hepatomegaly and disrupted hepatic function due to the lack of FXR signaling.

Miyata, M., Shinno, K., Kinoshita, T., Kinoshita, Y., & Sugiura, Y. (2017) · Journal of Toxicological Sciences · doi:10.2131/jts.42.671 · Cited by 9

Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking

Giancristofaro, A., Barbosa, A. J. M., Ammazzalorso, A., Amoia, P., Filippis, B. D., Fantacuzzi, M., Giampietro, L., Maccallini, C., & Amoroso, R. (2018) · MedChemComm · doi:10.1039/c8md00272j · Cited by 10

Pinelliae Rhizoma Praeparatum Involved in the Regulation of Bile Acids Metabolism in Hepatic Injury

Guo, S., Zhang, S., Liu, L., Yang, P., Dang, X., Wei, H., Hu, N., Shi, L., & Zhang, Y. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00972 · Cited by 10

Serum levels of total bile acids are associated with an increased risk of HCC in patients with cirrhosis

El‐Serag, H. B., Thrift, A. P., Duong, H. T., Ning, J., Khaderi, S. A., Singal, A. G., Asrani, S. K., Marrero, J. A., Powell, H., Rizwan, K., et al. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000545 · Cited by 9

FXR-mediated antigen-specific CD8 + T cell enhances antitumor immunity in intrahepatic cholangiocarcinoma

Liu, S., Liang, Z., Zhu, L., Zheng, Y., Yu, H., Ye, S., Liang, T., Huang, L., Ouyang, J., Cao, Y., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-012259 · Cited by 9

Upregulation of thrombomodulin expression by activation of farnesoid X receptor in vascular endothelial cells.

He, X., Xu, Z., Wang, B., Zheng, Y.-R., Gong, W., Huang, G., Zhang, L., Li, Y., & He, F. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.08.020 · Cited by 9

Partial abrogation of FXR-KNG1 signaling by carboxyl-terminal truncated HBx-C30 in hepatitis B virus-associated hepatocellular carcinoma.

Niu, Y.-D., Chen, L., Wu, M.-P., Huang, W.-Y., Wu, X., Huang, D.-M., Xie, Y.-M., & Shi, G.-G. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198264 · Cited by 8

Farnesoid X receptor functions in cervical cancer via the p14ARF-mouse double minute 2-p53 pathway

Huang, X., Wang, B., Shen, H., Huang, D., & Shi, G. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07201-x · Cited by 8

Discovery of New Non‐Steroidal F arnesoid X R eceptor Modulators Through 3 D Shape Similarity Search and Structure‐Based Virtual Screening

Wang, L., Si, P., Sheng, Y., Chen, Y., Wan, P., Shen, X., Tang, Y., Chen, L., & Li, W. (2014) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12432 · Cited by 9

Fibroblast Growth Factor 19, a Double-Edged Sword

Jansen, P. L. M. (2017) · Hepatic Oncology · doi:10.2217/hep-2017-0008 · Cited by 9

Bile acid metabolism and hepatocellular carcinoma: mechanisms of drug resistance and intervention strategies

Lü, Y., Feng, X., Wang, Z., Zou, M., Xu, Z., Liu, Q.-J., Chen, W., Ding, J., & Liu, H. (2025) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbaf020 · Cited by 12

FXR Friend-ChIPs in the Enterohepatic System

Meadows, V., Yang, Z., Basaly, V., & Guo, G. L. (2023) · Seminars in Liver Disease · doi:10.1055/a-2128-5538 · Cited by 8

Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury

Liu, X., Khalafalla, M. G., Chung, C., Gindin, Y., Hubchak, S. C., LeCuyer, B. E., Kriegermeier, A. A., Zhang, D., Qiu, W., Ding, X., et al. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100289 · Cited by 8

Nuclear Receptor Modulators — Current Approaches and Future Perspectives

Kronenberger, T., Keminer, O., Wrenger, C., & Windshügel, B. (2015) · InTech eBooks · doi:10.5772/59666 · Cited by 9

Activation of Farnesoid X Receptor Increases the Expression of Cytokine Inducible SH2-Containing Protein in HepG2 Cells

Xu, Z., Huang, G., Gong, W., Zhao, Y., Zhou, P., Zeng, Y., & He, F. (2012) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2012.0008 · Cited by 8

Transcriptional Control of Trpm6 by the Nuclear Receptor FXR

Kim, E. Y., & Lee, J. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041980 · Cited by 7

Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor–deficient mice

Golonka, R. M., Yeoh, B. S., Saha, P., Gohara, A. F., Tummala, R., Stepkowski, S. M., Tiwari, A. K., Joe, B., Gonzalez, F. J., Gewirtz, A. T., et al. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000166 · Cited by 8

Role of cholesterol homeostasis in MASH-driven hepatocellular carcinoma: not just a neutral fat

Ribas, V. (2024) · Exploration of Digestive Diseases · doi:10.37349/edd.2024.00048 · Cited by 8

Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver

Zhu, Y., Li, G., Dong, Y., Zhou, H. H., Kong, B., Aleksunes, L. M., Richardson, J. R., Li, F., & Guo, G. L. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.11.012 · Cited by 7

Regulation of N-Myc downstream regulated gene 2 by bile acids

Langhi, C., Pedraz‐Cuesta, E., Donate, Y., Marrero, P. F., Haro, D., & Rodríguez, J. C. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.03.058 · Cited by 8

The Identification of Pivotal Transcriptional Factors Mediating Cell Responses to Drugs With Drug-Induced Liver Injury Liabilities

Shah, F., Medvedev, A. V., Wassermann, A. M., Brodney, M. D., Zhang, L., Makarov, S. S., & Stanton, R. V. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx231 · Cited by 7

FXR agonists for colorectal and liver cancers, as a stand-alone or in combination therapy

Yu, D., Lu, Z., Wang, R., Xiang, Y., Li, H., Lu, J., Zhang, L., Chen, H., Li, W., Luan, X., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115570 · Cited by 7

Association Between Gadoxetic Acid-Enhanced Magnetic Resonance Imaging, Organic Anion Transporters, and Farnesoid X Receptor in Benign Focal Liver Lesions

van Rosmalen, B. V., Visentin, M., Furumaya, A., van Delden, O. M., Geert Kazemier, M., van Gulik, T. M., Verheij, J., & Stieger, B. (2023) · Drug Metabolism and Disposition · doi:10.1124/dmd.123.001492 · Cited by 6

Bile Acids and Farnesoid X Receptor in Renal Pathophysiology

Yang, J., Pontoglio, M., & Terzi, F. (2024) · The Nephron journals/Nephron journals · doi:10.1159/000538038 · Cited by 6

Impact of dietary carbohydrate restriction on the pathobiology of Hepatocellular Carcinoma: The gut-liver axis and beyond

Cramer, T. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101736 · Cited by 6

Chronic activation of FXR-induced liver growth with tissue-specific targeting Cyclin D1

Wu, W., Wu, Q., & Liu, X.-M. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1634955 · Cited by 6

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and femalesPreprint

Patton, M. E., Kelekar, S., Taylor, L. J., Dean, A. E., Zuo, Q., Thakare, R. N., Lee, S. H., Gentry, E. C., Panitchpakdi, M. W., Dorrestein, P. C., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.25.172635 · Cited by 8

Liver Metabolism at the Crossroads: The Reciprocal Control of Nutrient-Sensing Nuclear Receptors and Autophagy

Kim, E. Y., & Lee, J. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125825 · Cited by 7

Farnesoid X Receptor Attenuates the Tumorigenicity of Liver Cancer Stem Cells by Inhibiting STAT3 Phosphorylation

Ye, W.-L., Zhao, Y., Wang, Y.-B., Wang, Y.-H., Zhang, H., Wang, F.-L., & Chen, W. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031122 · Cited by 6

Hepatic Nuclear Receptors in Cholestasis-to-Cholangiocarcinoma Pathology

Cheon, I., Kim, M., Kim, K. H., & Ko, S. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.07.023 · Cited by 5

Glycyrrhetic Acid Derivative TY501 Protects Against Lithocholic Acid–Induced Cholestasis

Zheng, X., Zhu, S., Zhou, Z., Liu, W., & Xu, W. (2017) · Drug Research · doi:10.1055/s-0043-122222 · Cited by 5

Molecular mechanism for the involvement of nuclear receptor FXR in HBV-associated hepatocellular carcinoma

Niu, Y., Xie, W., & Qin, W. (2011) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2011.06.001 · Cited by 5

Microbial Metabolites as Molecular Mediators of Host-Microbe Symbiosis in Colorectal Cancer

Keane, J. M., Joyce, S. A., Gahan, C. G. M., Hyland, N. P., & Houston, A. M. (2020) · Results and problems in cell differentiation · doi:10.1007/978-3-030-51849-3_22 · Cited by 5

System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cellsPreprint

Wigger, L., Casals-Casas, C., Baruchet, M., Trang, K. B., Pradervand, S., Naldi, A., & Desvergne, B. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/514976 · Cited by 5

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and femalesPreprint

Patton, M. E., Kelekar, S., Taylor, L. J., Dean, A. E., Zuo, Q., Thakare, R. N., Lee, S.-H., Gentry, E. C., Panitchpakdi, M. W., Dorrestein, P. C., et al. (2024) · eLife · doi:10.7554/elife.96783.1 · Cited by 4

Therapeutic targets for metabolic dysfunction-associated steatotic liver disease and their roles in hepatocellular carcinoma

Wei, C., Wu, J., Zhang, C., Zhao, Y., Li, C., & Yang, X. (2023) · Exploration of Digestive Diseases · doi:10.37349/edd.2023.00031 · Cited by 3

FXR splicing by SF3B3 promotes MYC-driven hepatocarcinogenesis

Wang, X., Luo, J., Han, L., Xu, T., Wang, H., Zhang, M., Li, G. L., Li, X., Zhang, W., & Zhang, Y. (2025) · Hepatology · doi:10.1097/hep.0000000000001523 · Cited by 3

Combined, elobixibat, and colestyramine reduced cholesterol toxicity in a mouse model of metabolic dysfunction-associated steatotic liver disease

Iwaki, M., Kessoku, T., Tanaka, K., Ozaki, A., Kasai, Y., Kobayashi, T., Nogami, A., Honda, Y., Ogawa, Y., Imajo, K., et al. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000285 · Cited by 4

Farnesoid X receptor‑driven metabolic plasticity: Bridging physiological adaptation and malignant transformation in lipid handling (Review)

Sun, Y., Sun, K., Ling, H., & Xia, Q. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5551 · Cited by 4

Chapter 1 Regulation of Metabolism by Nuclear Hormone Receptors

Huang, H.-J., & Schulman, I. G. (2009) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(09)87001-4 · Cited by 3

Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development

Takahashi, S., Tanaka, N., Fukami, T., Xie, C., Yagai, T., Kim, D., Velenosi, T. J., Yan, T., Krausz, K. W., Levi, M., et al. (2018) · Hepatology Communications · doi:10.1002/hep4.1263 · Cited by 49

Endogenous bile acids as carcinogens

Jansen, P. L. M. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.06.001 · Cited by 52

Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor

Yang, F., Huang, X., Yi, T., Yen, Y., Moore, D. D., & Huang, W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1078 · Cited by 488

606 Integrated analysis of genome-wide copy number and expression changes reveals novel genes in oesophageal adenocarcinoma

Goh, X. Y., Rees, J. R., Paterson, A., Chin, S., O'Donovan, M., Alderson, D., Yistra, B., Caldas, C., & Fitzgerald, R. C. (2010) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(10)72313-2

Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis

Kong, B., Zhu, Y., Li, G., Williams, J. A. R., Buckley, K., Tawfik, O. W., Luyendyk, J. P., & Guo, G. L. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00134.2015 · Cited by 50