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Cited by 128Genomics, phytochemicals, and oxidative stressGlutathione Transferases and PolymorphismsPharmacogenetics and Drug Metabolism

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Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China

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Kensler, Thomas W., Ng, Derek, Carmella, Steven G., Chen, Menglan, Jacobson, Lisa P., Muñoz, Alvaro, Egner, Patricia A., Chen, Jian Guo, Qian, Geng Sun, Chen, Tao Yang, Fahey, Jed W., Talalay, Paul, Groopman, John D., Yuan, Jian-Min, Hecht, Stephen S.·2012·Carcinogenesis
DOI 10.1093/carcin/bgr229PMC PMC3276337
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Abstract

Epidemiological evidence has suggested that consumption of a diet rich in cruciferous vegetables reduces the risk of several types of cancers and chronic degenerative diseases. In particular, broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can release the chemopreventive agent, sulforaphane, an inducer of glutathione S-transferases. Two broccoli sprout-derived beverages, one sulforaphane-rich (SFR) and the other glucoraphanin-rich (GRR), were evaluated for pharmacodynamic action in a crossover clinical trial design. Study participants were recruited from the farming community of He Zuo Township, Qidong, China, previously documented to have a high incidence of hepatocellular carcinoma with concomitant exposures to aflatoxin and more recently characterized with exposures to substantive levels of airborne pollutants. Fifty healthy participants were randomized into two treatment arms. The study protocol was as follows: a 5 days run-in period, a 7 days administration of beverage, a 5 days washout period and a 7 days administration of the opposite beverage. Urinary excretion of the mercapturic acids of acrolein, crotonaldehyde, ethylene oxide and benzene were measured both pre- and postinterventions using liquid chromatography tandem mass spectrometry. Statistically significant increases of 20-50% in the levels of excretion of glutathione-derived conjugates of acrolein, crotonaldehyde and benzene were seen in individuals receiving SFR, G…

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  • Clinical trials with broccoli sprouts in populations highly exposed to air pollution demonstrate the ability of antioxidant pathway activation via Nrf2 to increase metabolism and excretion of airborne pollutants in healthy adults.

    “Clinical trials with broccoli sprouts, rich in the chemoprotective compound glucoraphanin and its biologically active metabolite sulforaphane, in populations highly exposed to air pollution demonstrate the ability of antioxidant pathway activation via Nrf2 to increase metabolism and excretion of airborne pollutants in healthy adults [212].”

    From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [212]

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Metadata

Authors
Kensler, T. W., Ng, D., Carmella, S. G., Chen, M., Jacobson, L. P., Muñoz, A., Egner, P. A., Chen, J. G., Qian, G. S., Chen, T. Y., Fahey, J. W., Talalay, P., Groopman, J. D., Yuan, J.-M., & Hecht, S. S.
Affiliations
  • Johns Hopkins University (US)
  • University of Minnesota (US)
  • Qidong Liver Cancer Prevention Research (CN)
Corresponding author
Kensler, Thomas W.
ORCID
Venue
Carcinogenesis
Publisher
Oxford University Press (OUP)
Published
2011-11-01
Volume
33
Issue
1
Pages
101-107
ISSN
  • 0143-3334 (ISSN-L)
  • 1460-2180
DOI
10.1093/carcin/bgr229
PMC
PMC3276337
OpenAlex
W2165080088
Cited by
128
References
0
Citations by year
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FWCI
3.64
Type
journal article
Language
en
Open access
Locations
  • Carcinogenesis (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute (R01 CA93780, R01CA093780)
  • National Institute of Environmental Health Sciences (P01ES006052, P30ES003819)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords
glucoraphanin, sulforaphane, glucosinolates, air pollutants, detoxification, acrolein, crotonaldehyde, ethylene oxide, benzene, mercapturic acids, glutathione S-transferase induction, hepatocellular carcinoma, aflatoxins, cruciferous vegetables, chemoprevention, agricultural communities
MeSH terms
Acetylcysteine, Acrolein, Adult, Air Pollutants, Aldehydes, Benzene, Beverages, Brassica, China, Ethylene Oxide, Female, Glucosinolates, Humans, Imidoesters, Male, Middle Aged, Oximes, Polycyclic Aromatic Hydrocarbons, Smoking, Sulfoxides, Thiocyanates, Biomarkers, Isothiocyanates, DNA Adducts

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