Kensler, Thomas W.

Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

Kensler, T. W., Wakabayashi, N., & Biswal, S. (2007) · Annual Review of Pharmacology and Toxicology

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 3,630

The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis

Yamamoto, M., Kensler, T. W., & Motohashi, H. (2018) · Physiological Reviews

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,968

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

Ramos-Gomez, M., Kwak, M.-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., & Kensler, T. W. (2001) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 1,102

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M.-I., Kobayashi, A., Yamamoto, M., Kensler, T. W., & Talalay, P. (2004) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 986

Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology

Kensler, T. W., Roebuck, B. D., Wogan, G. N., & Groopman, J. D. (2011) · Toxicological Sciences

Mycotoxins in Agriculture and FoodCarcinogens and Genotoxicity Assessment

Cited by 703

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

Wakabayashi, J., Zhang, Z., Wakabayashi, N., Tamura, Y., Fukaya, M., Kensler, T. W., Iijima, M., & Sesaki, H. (2009) · Journal of Cell Biology

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 667

When NRF2 Talks, Who's Listening?

Wakabayashi, N., Slocum, S. L., Skoko, J. J., Shin, S., & Kensler, T. W. (2010) · Antioxidants & Redox Signaling

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 595

Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

Rangasamy, T., Guo, J., Mitzner, W. A., Roman, J., Singh, A., Fryer, A. D., Yamamoto, M., Kensler, T. W., Tuder, R. M., Georas, S. N., et al. (2005) · The Journal of Experimental Medicine

Asthma and respiratory diseasesGenomics, phytochemicals, and oxidative stress

Cited by 580

Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2

Kadl, A., Meher, A. K., Sharma, P. R., Lee, M. Y., Doran, A. C., Johnstone, S. R., Elliott, M. R., Gruber, F., Han, J., Chen, W., et al. (2010) · Circulation Research

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 573

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

Sussan, T. E., Rangasamy, T., Blake, D. J., Malhotra, D., El-Haddad, H., Bedja, D., Yates, M. S., Kombairaju, P., Yamamoto, M., Liby, K. T., et al. (2009) · Proceedings of the National Academy of Sciences

Chronic Obstructive Pulmonary Disease (COPD) ResearchGenomics, phytochemicals, and oxidative stress

Cited by 346

Myeloperoxidase as a Biomarker of Skin Irritation and Inflammation

Trush, M. A., Egner, P. A., & Kensler, T. W. (1994) · Food and Chemical Toxicology

Contact Dermatitis and AllergiesImmunotoxicology and immune responses

Cited by 146

Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China

Kensler, T. W., Ng, D., Carmella, S. G., Chen, M., Jacobson, L. P., Muñoz, A., Egner, P. A., Chen, J. G., Qian, G. S., Chen, T. Y., et al. (2012) · Carcinogenesis

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 128

Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence

Volonte, D., Liu, Z., Musille, P. M., Stoppani, E., Wakabayashi, N., Di, Y.-P., Lisanti, M. P., Kensler, T. W., & Galbiati, F. (2013) · Molecular Biology of the Cell

Genomics, phytochemicals, and oxidative stressCaveolin-1 and cellular processes

Cited by 119

Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model: Astrocytic Nrf2 Hyperactivation Prevents the Formation of Demyelinating Lesions

Draheim, T., Liessem, A., Scheld, M., Wilms, F., Weißflog, M., Denecke, B., Kensler, T. W., Zendedel, A., Beyer, C., Kipp, M., et al. (2016) · Glia

Multiple Sclerosis Research StudiesGenomics, phytochemicals, and oxidative stress

Cited by 95

NF‐E2‐related factor 2 regulates the stress response to UVA‐1‐oxidized phospholipids in skin cells

Gruber, F., Mayer, H., Lengauer, B., Mlitz, V., Sanders, J. M., Kadl, A., Bilban, M., de Martin, R., Wagner, O., Kensler, T. W., et al. (2010) · The FASEB Journal

Genomics, phytochemicals, and oxidative stressSkin Protection and Aging

Cited by 80

Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development

Ramadori, P., Drescher, H., Erschfeld, S., Schumacher, F., Berger, C., Fragoulis, A., Schenkel, J., Kensler, T. W., Wruck, C. J., Trautwein, C., et al. (2016) · Free Radical Biology and Medicine

Liver Disease Diagnosis and TreatmentGenomics, phytochemicals, and oxidative stress

Cited by 61

Health position paper and redox perspectives – Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases

Cuadrado, A., Cazalla, E., Bach, A., Bathish, B., Naidu, S. D., DeNicola, G. M., Dinkova-Kostova, A. T., Fernández-Ginés, R., Grochot-Przeczek, A., Hayes, J. D., et al. (2025) · Redox Biology

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 28