The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies
Open accessAbstract
Cellular senescence, a state of stable growth arrest, can occur in response to various stress stimuli such as telomere shortening, treatment with chemotherapeutic drugs or the aberrant activation of oncogenes. Senescent cells communicate with their environment by secreting various cytokines and growth factors, and it has become clear that this 'secretory phenotype' can have pro- as well as anti-tumorigenic effects. Recent work from our laboratory showed that premalignant, senescent hepatocytes are recognized and cleared through an antigen-specific immune response and that this immune response, designated as 'senescence surveillance' is crucial for tumor suppression in the liver [(Kang,T.W. et al. (2011) Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature, 479, 547-551]. It is an emerging concept that immune responses against senescent cells have a broader biological significance in cancer- as well as non-cancer pathologies and current data suggest that distinct immune responses are engaged to clear senescent cells in different disease settings. In this review article, we will discuss different examples how immune responses against senescent cells are involved to restrict disease progression in cancer- and non-cancer pathologies.
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“In the case of senescent tumor cells, there is good evidence that they are subjected to strict immune surveillance and are efficiently removed by phagocytosis”
From The Hallmarks of Aging (2013) · cites this paper as Hoenicke and Zender, 2012
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Senescent cells can be eliminated through a SASP-induced immune response, which can involve both innate and adaptive immunity.”
From Inside and out: the activities of senescence in cancer (2014) · cites this paper as [111]
In the citing paper
“Although senescent cells can be recognized by T helper cells and cleared by macrophages and natural killer lymphocytes [27,34,35], their number has been shown to increase with normal ageing in tissues of humans, primates and rodents [36,37].”
From Ageing, Cellular Senescence and Neurodegenerative Disease (2018) · cites this paper as [35]
In the citing paper
“activating an immune response”
From Inside and out: the activities of senescence in cancer (2014) · cites this paper as [111]
In the citing paper
“Indeed, senescent cells formed following tissue damage can promote their own clearance by secreting chemo-attractants that recruit and activate immune cells [265].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [265]
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Citations
Cites
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“Most strikingly, late-life clearance of senescent cells still attenuated progression of already established age-related disorders (40).”
BackgroundSenescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473
Self-citationSenescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232
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Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086
Research works printed but not linked: 2
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Cited by
Sorted by citations
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
“In the case of senescent tumor cells, there is good evidence that they are subjected to strict immune surveillance and are efficiently removed by phagocytosis (Hoenicke and Zender, 2012; Kang et al., 2011; Xue et al., 2007).”
BackgroundCellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818
Cellular senescence in aging and age-related disease: from mechanisms to therapy
Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774
Programmed cell senescence during mammalian embryonic development
Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.019 · Cited by 1,428
“…secretory phenotype (SASP) can also evoke a local inflammatory response with complex effects, including the elimination of senescent cells by phagocytosis, thus leading to tissue remodeling and damage resolution (Freund et al., 2010; Hoenicke and Zender, 2012; Krizhanovsky et al., 2008).”
Influential
Metadata
- Authors
- Hoenicke, L., & Zender, L.
- Affiliations
- Helmholtz Centre for Infection Research (DE)
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Zender, L.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-04-02
- Volume
- 33
- Issue
- 6
- Pages
- 1123-1126
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2121022075
- Cited by
- 248
- References
- 40
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 11 · 2023: 15 · 2022: 26 · 2021: 21 · 2020: 31 · 2019: 24 · 2018: 24 · 2017: 14 · 2016: 22 · 2015: 14 · 2014: 12 · 2013: 17 · 2012: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Carcinogenesis (publishedVersion)
- PubMed (publishedVersion)
- HZI (Helmholtz Centre for Infection Research) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- cellular senescence, senescence-associated secretory phenotype, tumor suppression, liver cancer, antigen-specific immune response, tumor immunology, telomere shortening, chemotherapy-induced senescence, oncogene activation
- MeSH terms
- Humans, Immunologic Surveillance, Liver, Neoplasms, Precancerous Conditions, Cytokines, Cellular Senescence, Disease Progression, Chemokines, Hepatocytes
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