The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
GABA Receptor Antagonists Modulate Postmitotic Cell Migration in Slice Cultures of Embryonic Rat Cortex
Abstract
Recent studies indicate that GABA acts as a chemoattractant during rat cortical histogenesis. In vivo, GABA localizes in appropriate locations for a chemoattractant, along migratory routes and near target destinations for migrating cortical neurons. In vitro, GABA induces dissociated embryonic cortical neurons to migrate. Here, embryonic rat cortical slices were cultured in the presence or absence of GABA receptor (GABA-R) antagonists to assess GABA's effects on neuronal migration in situ. Gestational day 18 (E18) cortical slices were incubated overnight in bromodeoxyuridine (BrdU)-containing medium to label ventricular zone (vz) cells as they underwent terminal mitosis. The slices were then cultured in BrdU-free medium with or without GABA-R antagonists. In control slices, most BrdU(+) cells were observed in the cortical plate (cp) after 48 h. In contrast, cultures maintained in either saclofen (a GABA(B)-R antagonist) or picrotoxin (a GABA(A/C)-R antagonist) had few BrdU-labeled cp cells. However, the effects of the two antagonists were distinct. In the picrotoxin-treated slices, nearly half of all BrdU(+) cells remained in the vz and subventricular zone (svz), whereas saclofen treatment resulted in an accumulation of BrdU(+) cells in the intermediate zone (iz). Bicuculline, a GABA(A)-R antagonist, did not block, but rather enhanced migration of BrdU(+) cells into the cp. These results provide evidence that picrotoxin-sensitive receptors promote the migration of vz/svz cells into the iz, while saclofen-sensitive receptors signal cells to migrate into the cp. Thus, as cortical cells differentiate, changing receptor expression appears to modulate migratory responses to GABA.
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“GABA has been shown to influence neuronal migration in the embryonic cortex (Behar et al., 2000; López-Bendito et al., 2003), the settlement of interneurons in the cortical plate (Bortone and Polleux, 2009), and the formation on inhibitory synapses (Oh et al., 2016), and may also influence the neurogenesis of pyramidal cells (Silva et al., 2018).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Behar et al., 2000
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Cites
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A role for Cajal–Retzius cells and reelin in the development of hippocampal connections
Del Río, J. A., Heimrich, B., Borrell, V., Förster, E., Drakew, A., Alcántara, S., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., et al. (1997) · Nature · doi:10.1038/385070a0 · Cited by 472
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GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Ben-Ari, Y., Gaiarsa, J.-L., Tyzio, R., & Khazipov, R. (2007) · Physiological Reviews · doi:10.1152/physrev.00017.2006 · Cited by 1,304
Is there more to gaba than synaptic inhibition?
Owens, D. F., & Kriegstein, A. R. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn919 · Cited by 1,172
C ELL M IGRATION IN THE F OREBRAIN
Marín, Ó., & Rubenstein, J. L. R. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131058 · Cited by 957
Development and Functional Diversification of Cortical Interneurons
Lim, L., Mi, D., Llorca, A., & Marín, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.009 · Cited by 714
“Are some of the transient interneurons important for shaping early neuronal networks, similar to Cajal-Retzius cells? GABA has been shown to influence neuronal migration in the embryonic cortex (Behar et al., 2000; López-Bendito et al., 2003), the settlement of interneurons in the cortical plate (Bortone and Polleux,…”
Wichterle, H., Turnbull, D. H., Nery, S., Fishell, G., & Alvarez-Buylla, A. (2001) · Development · doi:10.1242/dev.128.19.3759 · Cited by 722
Metadata
- Authors
- Behar, T. N.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Behar, T. N.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-09-01
- Volume
- 10
- Issue
- 9
- Pages
- 899-909
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2135435398
- Cited by
- 218
- References
- 43
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 10 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 17 · 2012: 10
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- GABA receptor antagonists, neuronal migration, picrotoxin, saclofen, bicuculline, GABAB receptors, GABAA receptor, GABAC receptors, ventricular zone, subventricular zone, intermediate zone, cortical plate, BrdU labeling
- MeSH terms
- Animals, Baclofen, Bicuculline, Bromodeoxyuridine, Cell Movement, Cerebral Cortex, Chemotaxis, Female, gamma-Aminobutyric Acid, Glial Fibrillary Acidic Protein, Intermediate Filament Proteins, Mitosis, Nerve Tissue Proteins, Neuroglia, Neurons, Organ Culture Techniques, Picrotoxin, Pregnancy, Receptors, GABA-A, Cellular Senescence, GABA Antagonists, Rats, Nestin
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