Dual Role of Brain Factor-1 in Regulating Growth and Patterning of the Cerebral Hemispheres
Abstract
Brain factor-1 (BF-1) is a winged-helix (WH) transcription factor with a restricted pattern of expression in the neural tube. In the embryo, BF-1 is localized to the progenitor cells of the most rostral neural tube, the telencephalic neuroepithelium. Expression of BF-1 persists in the adult brain in the structures derived from the telencephalon, including the cerebral cortex, the hippocampus, the olfactory bulbs and the basal ganglia. Targeted disruption of the BF-1 gene in mice results in hypoplasia of the cerebral hemispheres. Proliferation of the telencephalic neuroepithelium is decreased and neuronal differentiation occurs prematurely. The forebrain of the BF-1 (-/-) mutant also displays dorsal-ventral patterning defects. Development of the ventral (basal) region of the telencephalon is more severely affected than the dorsal region. These anomalies are associated with the ectopic expression of BMP4 in the dorsal telencephalic neuroepithelium and the loss of shh in the ventral telencephalon. These results raise the possibility that BF-1 may modulate both progenitor cell proliferation and regional patterning by regulating the expression or activity of inductive signals which act on the telencephalic neuroepithelium.
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NeuN and BF-1 are markers for neuronal viability.
“To determine whether there was any effect on neuronal viability, we examined two additional markers by western blot, NeuN36 and BF-137.”
From A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system (2019) · cites this paper as [37]
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- Authors
- Dou, C.-L.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Dou, C.-L.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-09-01
- Volume
- 9
- Issue
- 6
- Pages
- 543-550
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2114327257
- Cited by
- 152
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 8 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 10
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- winged helix transcription factor, dorsoventral patterning, BMP4, Sonic hedgehog, neuronal differentiation, progenitor cell proliferation, forebrain patterning, BMP signaling, Sonic hedgehog signaling
- MeSH terms
- Animals, beta-Galactosidase, Brain Chemistry, Cell Cycle, Cell Differentiation, DNA-Binding Proteins, Female, Lac Operon, Microtubule-Associated Proteins, Nerve Tissue Proteins, Neurons, Pregnancy, Stem Cells, Transcription Factors, Genes, Reporter, Mice, Knockout, Gene Expression Regulation, Developmental, Bone Morphogenetic Proteins, Neocortex, Mice, Forkhead Transcription Factors, Bone Morphogenetic Protein 4
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