The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Sex Differences and the Impact of Steroid Hormones on the Developing Human Brain
Open accessAbstract
Little is known about the hormonal effects of puberty on the anatomy of the developing human brain. In a voxel-based morphometry study, sex-related differences in gray matter (GM) volume were examined in 46 subjects aged 8-15 years. Males had larger GM volumes in the left amygdala, whereas females had larger right striatal and bilateral hippocampal GM volumes than males. Sexually dimorphic areas were related to Tanner stages (TS) of pubertal development and to circulating level of steroid hormones in a subsample of 30 subjects. Regardless of sex, amygdala and hippocampal volumes varied as a function of TS and were associated with circulating testosterone (TEST) levels. By contrast, striatal GM volumes were unrelated to pubertal development and circulating steroid hormones. Whole-brain regression analyses revealed positive associations between circulating estrogen levels and parahippocampal GM volumes as well as between TEST levels and diencephalic brain structures. In addition, a negative association was found between circulating TEST and left parietal GM volumes. These data suggest that GM development in certain brain regions is associated with sexual maturation and that pubertal hormones might have organizational effects on the developing human brain.
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Cited by
A meta-analysis of sex differences in human brain structure
Ruigrok, A. N. V., Salimi-Khorshidi, G., Lai, M.-C., Baron-Cohen, S., Lombardo, M. V., Tait, R. J., & Suckling, J. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.004 · Cited by 1,192
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The role of puberty in the developing adolescent brain
Blakemore, S., Burnett, S., & Dahl, R. E. (2010) · Human Brain Mapping · doi:10.1002/hbm.21052 · Cited by 1,011
Tamnes, C. K., Østby, Y., Fjell, A. M., Westlye, L. T., Due-Tønnessen, P., & Walhovd, K. B. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp118 · Cited by 779
Gillies, G. E., & McArthur, S. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002071 · Cited by 733
Metadata
- Authors
- Neufang, S., Specht, K., Hausmann, M., Gunturkun, O., Herpertz-Dahlmann, B., Fink, G. R., & Konrad, K.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-06-11
- Volume
- 19
- Issue
- 2
- Pages
- 464-473
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2139890969
- Cited by
- 423
- References
- 73
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Neufang, S., Specht, K., Hausmann, M., Gunturkun, O., Herpertz-Dahlmann, B., Fink, G. R., & Konrad, K. (2009). Sex Differences and the Impact of Steroid Hormones on the Developing Human Brain. Cerebral Cortex. https://doi.org/10.1093/cercor/bhn100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
