Severe Scene Learning Impairment, but Intact Recognition Memory, after Cholinergic Depletion of Inferotemporal Cortex Followed by Fornix Transection

Browning, P. G. F.; Gaffan, D.; Croxson, P. L.; Baxter, M. G.

doi:10.1093/cercor/bhp097

Cited by 46Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

Severe Scene Learning Impairment, but Intact Recognition Memory, after Cholinergic Depletion of Inferotemporal Cortex Followed by Fornix Transection

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Browning, P. G. F., Gaffan, D., Croxson, P. L., Baxter, M. G.·2010·Cerebral Cortex

DOI 10.1093/cercor/bhp097PMC PMC2803729

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Abstract

To examine the generality of cholinergic involvement in visual memory in primates, we trained macaque monkeys either on an object-in-place scene learning task or in delayed nonmatching-to-sample (DNMS). Each monkey received either selective cholinergic depletion of inferotemporal cortex (including the entorhinal cortex and perirhinal cortex) with injections of the immunotoxin ME20.4-saporin or saline injections as a control and was postoperatively retested. Cholinergic depletion of inferotemporal cortex was without effect on either task. Each monkey then received fornix transection because previous studies have shown that multiple disconnections of temporal cortex can produce synergistic impairments in memory. Fornix transection mildly impaired scene learning in monkeys that had received saline injections but severely impaired scene learning in monkeys that had received cholinergic lesions of inferotemporal cortex. This synergistic effect was not seen in monkeys performing DNMS. These findings confirm a synergistic interaction in a macaque monkey model of episodic memory between connections carried by the fornix and cholinergic input to the inferotemporal cortex. They support the notion that the mnemonic functions tapped by scene learning and DNMS have dissociable neural substrates. Finally, cholinergic depletion of inferotemporal cortex, in this study, appears insufficient to impair memory functions dependent on an intact inferotemporal cortex.

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Cholinergic lesions of inferotemporal cortex in monkeys do not impair visual scene learning unless combined with fornix lesions.
“Cholinergic lesions of inferotemporal cortex in monkeys do not impair visual scene learning unless combined with fornix lesions (Browning et al., 2010).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Browning et al., 2010

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Cerebral Cortex doi:10.1093/cercor/bhp097 Severe Scene Learning Impairment, but Intact Recognition Memory, after Cholinergic Depletion of Inferotemporal Cortex Followed by Fornix Transection
Browning, P. G. F., Gaffan, D., Croxson, P. L., & Baxter, M. G. (2014)
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Authors: Browning, P. G. F., Gaffan, D., Croxson, P. L., & Baxter, M. G.
Affiliations: University of Oxford (GB)
Corresponding author: Browning, P. G. F.
ORCID: Browning, P. G. F.
Croxson, P. L.
Baxter, M. G.
Venue: Cerebral Cortex
Publisher: Oxford University Press (OUP)
Published: 2009-05-15
Volume: 20
Issue: 2
Pages: 282-293
ISSN: 1047-3211 (ISSN-L)
1460-2199
DOI: 10.1093/cercor/bhp097
PMC: PMC2803729
OpenAlex: W2097872540
Cited by: 46
References: 30
Citations by year: 2025: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 3 · 2012: 7
FWCI: 2.42
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Cerebral Cortex (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: Wellcome Trust (071291)
Medical Research Council (MC_qA137504)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: recognition memory, cholinergic depletion, inferotemporal cortex, fornix transection, delayed nonmatching-to-sample, episodic memory, entorhinal cortex, perirhinal cortex, cholinergic input, macaque, memory dissociation
MeSH terms: Acetylcholine, Afferent Pathways, Animals, Cholinergic Fibers, Denervation, Hippocampus, Learning, Learning Disabilities, Macaca fascicularis, Macaca mulatta, Male, Neuropsychological Tests, Neurotoxins, Teaching, Temporal Lobe, Visual Perception, Neurosurgical Procedures, Axotomy, Basal Nucleus of Meynert, Fornix, Brain, Recognition, Psychology

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Severe Scene Learning Impairment, but Intact Recognition Memory, after Cholinergic Depletion of Inferotemporal Cortex Followed by Fornix Transection

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