The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Uncertainty during Anticipation Modulates Neural Responses to Aversion in Human Insula and Amygdala
Open accessAbstract
Uncertainty about potential negative future outcomes can cause stress and is a central feature of anxiety disorders. The stress and anxiety associated with uncertain situations may lead individuals to overestimate the frequency with which uncertain cues are followed by negative outcomes, an example of covariation bias. Using functional magnetic resonance imaging, we found that uncertainty-related expectations modulated neural responses to aversion. Insula and amygdala responses to aversive pictures were larger after an uncertain cue (that preceded aversive or neutral pictures) than a certain cue (that always preceded aversive pictures). Anticipatory anterior cingulate cortex (ACC) activity elicited by the cues was inversely associated with the insula and amygdala responses to aversive pictures following the cues. Nearly 75% of subjects overestimated the frequency of aversive pictures following uncertain cues, and ACC and insula activity predicted this uncertainty-related covariation bias. Findings provide the first evidence of the brain mechanisms of covariation bias and highlight the temporal dynamics of ACC, insula, and amygdala recruitment for processing aversion in the context of uncertainty.
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In the citing paper
“AIC responses to expected aversive stimuli are larger if expectations are uncertain”
From An Interoceptive Predictive Coding Model of Conscious Presence (2012) · cites this paper as Sarinopoulos et al., 2010
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“In their study, insula and amygdala responses were larger after an uncertain cue than a certain cue.”
From Extension of the Transdiagnostic Model to Focus on Intolerance of Uncertainty: A Review of the Literature and Implications for Treatment (2014) · cites this paper as Sarinopoulos et al. (2010)
In the citing paper
“Studies of instructed fear that have examined neural activity underlying both anticipation of and responses to briefly presented aversive pictures have also revealed dorsal amygdala activation (Mackiewicz et al., 2006; Nitschke et al., 2006), provided that the aversive events are predictably signaled (Sarinopoulos et al., 2010).”
From Phasic and sustained fear in humans elicits distinct patterns of brain activity (2011) · cites this paper as Sarinopoulos et al., 2010
In the citing paper
“Particularly, sources in the insula and amygdala, known to process subjective salience (Davis, & Whalen, 2001;Straube, & Miltner, 2011), corroborate imaging results, specifically uncertainty-related amygdalar hyperactivity in pediatric anxiety (Sarinopoulos et al., 2010;Williams et al., 2015).”
From Uncertainty increases neural indices of attention in obsessive-compulsive disorder (2017) · cites this paper as Sarinopoulos et al., 2010
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Citations
Cites
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
Rescorla, R. A. (1972) · Medical Entomology and Zoology · Cited by 7,268
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
Talairach, J., Tournoux, P., & Rayport, M. (1988) · Thieme eBooks · Cited by 5,058
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406 · cited 1×
“Current conceptualizations of insula function emphasize interoception and the detailed representation of the body’s internal state, including peripheral signals relevant for emotion (Craig 2002, 2009; Critchley 2004, 2005; Critchley et al. 2004).”
BackgroundContributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377
Research works printed but not linked: 1
- LeDoux, 2002, The synaptic self
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Sorted by citations
Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective
Grupe, D. W., & Nitschke, J. B. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3524 · Cited by 2,007
Self-citationGut feelings: the emerging biology of gut-brain communication
Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726
An Interoceptive Predictive Coding Model of Conscious Presence
Seth, A. K., Suzuki, K., & Critchley, H. D. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00395 · Cited by 950
“Moreover, AIC responses to expected aversive stimuli are larger if expectations are uncertain (Sarinopoulos et al., 2010).”
BackgroundThe Role of Emotion Regulation in Autism Spectrum Disorder
Mazefsky, C. A., Herrington, J., Siegel, M., Scarpa, A., Maddox, B. B., Scahill, L., & White, S. W. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.05.006 · Cited by 881
Self-citationUncertainty and stress: Why it causes diseases and how it is mastered by the brain
Peters, A., McEwen, B. S., & Friston, K. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.05.004 · Cited by 652
“…stress-related responses are broadcast by the ACC to the anterior insular and onto autonomic centers to elicit autonomic reflexes (Barrett and Simmons, 2015; Behrens et al., 2007; Feinstein et al., 2006; Karlsson et al., 2012; Liljeholm et al., 2013; Paulus et al., 2002; Sarinopoulos et al., 2010).”
Influential
Metadata
- Authors
- Sarinopoulos, I., Grupe, D. W., Mackiewicz, K. L., Herrington, J. D., Lor, M., Steege, E. E., & Nitschke, J. B.
- Affiliations
- Michigan State University (US)
- University of Wisconsin–Madison (US)
- University of Colorado Boulder (US)
- Children's Hospital of Philadelphia (US)
- Columbia University (US)
- West Virginia University (US)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-08-13
- Volume
- 20
- Issue
- 4
- Pages
- 929-940
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC2837092
- OpenAlex
- W2138497717
- Cited by
- 241
- References
- 114
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 9 · 2023: 9 · 2022: 18 · 2021: 15 · 2020: 11 · 2019: 9 · 2018: 22 · 2017: 14 · 2016: 18 · 2015: 18 · 2014: 21 · 2013: 20 · 2012: 17
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Waisman Center (HD03352)
- National Institutes of Health (5k02mh082130-05)
- National Institute of Mental Health (K02‑MH082130, P30-HD03352, R01MH074847, K08MH063984, R01-MH74847, K08-MH63984)
- National Institute of Child Health and Human Development (P30HD03352, HD03352)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD03352., P30HD003352)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- uncertainty, anticipation, aversion, insula, amygdala, anterior cingulate cortex, anxiety, stress, aversive stimuli, expectations, temporal dynamics of neural responses
- MeSH terms
- Affect, Amygdala, Avoidance Learning, Brain Mapping, Cues, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Photic Stimulation, Uncertainty, Young Adult
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