Studying the role of human parietal cortex in visuospatial attention with concurrent TMS-fMRI
Open accessAbstract
Combining transcranial magnetic stimulation (TMS) with concurrent functional magnetic resonance imaging (fMRI) allows study of how local brain stimulation may causally affect activity in remote brain regions. Here, we applied bursts of high- or low-intensity TMS over right posterior parietal cortex, during a task requiring sustained covert visuospatial attention to either the left or right hemifield, or in a neutral control condition, while recording blood oxygenation-level-dependent signal with a posterior MR surface coil. As expected, the active attention conditions activated components of the well-described "attention network," as compared with the neutral baseline. Also as expected, when comparing left minus right attention, or vice versa, contralateral occipital visual cortex was activated. The critical new finding was that the impact of high- minus low-intensity parietal TMS upon these visual regions depended on the currently attended side. High- minus low-intensity parietal TMS increased the difference between contralateral versus ipsilateral attention in right extrastriate visual cortex. A related albeit less pronounced pattern was found for left extrastriate visual cortex. Our results confirm that right human parietal cortex can exert attention-dependent influences on occipital visual cortex and provide a proof of concept for the use of concurrent TMS-fMRI in studying how remote influences can vary in a purely top-down manner with attentional demands.
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TMS interference with these areas impairs performance on said tasks.
“and interference with these areas using transcranial magnetic stimulation impairs performance on said tasks (e.g. [39]).”
From Linking ADHD to the Neural Circuitry of Attention (2017) · cites this paper as [39]
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- Authors
- Blankenburg, F., Ruff, C. C., Bestmann, S., Bjoertomt, O., Josephs, O., Deichmann, R., & Driver, J.
- Affiliations
- Wellcome Centre for Human Neuroimaging (GB)
- UCL Queen Square Institute of Neurology (GB)
- University College London (GB)
- University Hospital Frankfurt (DE)
- Corresponding author
- Blankenburg, F.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-02-22
- Volume
- 20
- Issue
- 11
- Pages
- 2702-2711
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC2951847
- OpenAlex
- W2112032082
- Cited by
- 132
- References
- 69
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 8 · 2023: 3 · 2022: 8 · 2021: 8 · 2020: 5 · 2019: 8 · 2018: 7 · 2017: 14 · 2016: 5 · 2015: 6 · 2014: 13 · 2013: 9 · 2012: 12
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Cerebral Cortex (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- reroDoc Digital Library (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) (submittedVersion, cc-by-nc)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Wellcome Trust (EU-FP7-, 200728)
- Bundesministerium für Bildung und Forschung
- Universität Zürich
- Directorate for Biological Sciences
- Medical Research Council (EU FP7)
- Biotechnology and Biological Sciences Research Council (BB/F02424X/1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Spatial Neglect and Hemispheric Dysfunction
- Keywords
- visuospatial attention, posterior parietal cortex, transcranial magnetic stimulation, covert attention, attentional networks, extrastriate cortex, top-down attentional control, hemifield attention, hemispheric lateralization
- MeSH terms
- Adult, Attention, Humans, Magnetic Resonance Imaging, Male, Orientation, Parietal Lobe, Space Perception, Transcranial Magnetic Stimulation
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