The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
The Role of Interneuron Networks in Driving Human Motor Cortical Plasticity
Abstract
The after-effects of repetitive transcranial magnetic stimulation (rTMS) are highly variable between individuals. Because different populations of cortical neurons are stimulated more easily or are more excitable in different people at different times, the variability may not be due to differences between individuals in the plasticity of cortical synapses, but may instead be due to individual differences in the recruitment of cortical neurons. In this study, we examined the effects of rTMS in 56 healthy volunteers. The responses to excitatory and inhibitory theta burst stimulation (TBS) protocols were highly variable between individuals. Surprisingly, the TBS effect was highly correlated with the latency of motor-evoked potentials (MEPs) evoked by TMS pulses that induced an anterior-posterior (AP) directed current across the central sulcus. Finally, we devised a new plasticity protocol using closely timed pairs of oppositely directed TMS current pulses across the central sulcus. Again, the after-effects were related to the latency of MEPs evoked by AP current. Our results are consistent with the idea that variation in response to rTMS plasticity probing protocols is strongly influenced by which interneuron networks are recruited by the TMS pulse.
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Cites
Rossi, S., Hallett, M., Rossini, P. M., & Pascual-Leone, A. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.08.016 · Cited by 5,367
Theta Burst Stimulation of the Human Motor Cortex
Huang, Y.-Z., Edwards, M. J., Rounis, E., Bhatia, K. P., & Rothwell, J. C. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.033 · Cited by 4,158
Self-citationRegulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
Markram, H., Lübke, J., Frotscher, M., & Sakmann, B. (1997) · Science · doi:10.1126/science.275.5297.213 · Cited by 3,832
Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954
Spike Timing–Dependent Plasticity: A Hebbian Learning Rule
Caporale, N., & Dan, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125639 · Cited by 1,997 · cited 2×
“Our hypothesis was that it recruits spike timing dependent plasticity (STDP) according to a “pre-post” rule in which synapses are strengthened if a presynaptic input is regularly followed by a postsynaptic discharge (Caporale and Dan 2008).”
MethodInduction of plasticity in the human motor cortex by paired associative stimulation
Stefan, K. (2000) · Brain · doi:10.1093/brain/123.3.572 · Cited by 1,481
Interaction between intracortical inhibition and facilitation in human motor cortex.
Ziemann, U., Rothwell, J. C., & Ridding, M. C. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021734 · Cited by 1,140
Self-citationDay, B. L., Dressler, D., Maertens de Noordhout, A., Marsden, C. D., Nakashima, K., Rothwell, J. C., & Thompson, P. D. (1989) · The Journal of Physiology · doi:10.1113/jphysiol.1989.sp017626 · Cited by 931
Self-citationRidding, M. C., & Ziemann, U. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.190314 · Cited by 787 · cited 5×
“Variability of TBS Responses As noted in the Introduction, there is a very large interindividual variation in the response to TMS protocols that test early forms of synaptic plasticity in the human motor cortex (Ridding and Ziemann 2010).”
BackgroundInfluentialCheeran, B., Talelli, P., Mori, F., Koch, G., Suppa, A., Edwards, M., Houlden, H., Bhatia, K., Greenwood, R., & Rothwell, J. C. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.159905 · Cited by 705
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Cited by
Rossini, P. M., Burke, D., Chen, R., Cohen, L. G., Daskalakis, Z., Di Iorio, R., Di Lazzaro, V., Ferreri, F., Fitzgerald, P. B., George, M. S., et al. (2015) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.02.001 · Cited by 2,753
Self-citationLefaucheur, J.-P., Aleman, A., Baeken, C., Benninger, D. H., Brunelin, J., Di Lazzaro, V., Filipović, S. R., Grefkes, C., Hasan, A., Hummel, F. C., et al. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.11.002 · Cited by 2,382
Self-citationLefaucheur, J.-P., André-Obadia, N., Antal, A., Ayache, S. S., Baeken, C., Benninger, D. H., Cantello, R. M., Cincotta, M., de Carvalho, M., De Ridder, D., et al. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2014.05.021 · Cited by 2,119
Self-citationInter-individual Variability in Response to Non-invasive Brain Stimulation Paradigms
López-Alonso, V., Cheeran, B., Río-Rodríguez, D., & Fernández-del-Olmo, M. (2014) · Brain Stimulation · doi:10.1016/j.brs.2014.02.004 · Cited by 810
Variability in Response to Transcranial Direct Current Stimulation of the Motor Cortex
Wiethoff, S., Hamada, M., & Rothwell, J. C. (2014) · Brain Stimulation · doi:10.1016/j.brs.2014.02.003 · Cited by 785
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Metadata
- Authors
- Hamada, M., Murase, N., Hasan, A., Balaratnam, M., & Rothwell, J. C.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-06-01
- Volume
- 23
- Issue
- 7
- Pages
- 1593-1605
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2102259310
- Cited by
- 769
- References
- 69
- FWCI
- 23.37
- Type
- journal article
- Language
- en
- Open access
- closed
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