The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
A common polymorphism in the brain‐derived neurotrophic factor gene ( BDNF ) modulates human cortical plasticity and the response to rTMS
Open accessAbstract
The brain‐derived neurotrophic factor gene ( BDNF ) is one of many genes thought to influence synaptic plasticity in the adult brain and shows a common single nucleotide polymorphism ( BDNF Val66Met) in the normal population that is associated with differences in hippocampal volume and episodic memory. It is also thought to influence possible synaptic changes in motor cortex following a simple motor learning task. Here we extend these studies by using new non‐invasive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (TDCS) techniques that directly test the excitability and plasticity of neuronal circuits in human motor cortex in subjects at rest. We investigated whether the susceptibility to TMS probes of plasticity is significantly influenced by the BDNF polymorphism. Val66Met carriers were matched with Val66Val individuals and tested on the following protocols: continuous and intermittent theta burst TMS; median nerve paired associative stimulation; and homeostatic plasticity in the TDCS/1 Hz rTMS model. The response of Met allele carriers differed significantly in all protocols compared with the response of Val66Val individuals. We suggest that this is due to the effect of BNDF on the susceptibility of synapses to undergo LTP/LTD. The circuits tested here are implicated in the pathophysiology of movement disorders such as dystonia and are being assessed as potential new targets in the treatment of stroke. Thus the polymorphism may be one factor that influences the natural response of the brain to injury and disease.
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Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., Egan, M. F., Meyer-Lindenberg, A., & Weinberger, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2680-04.2004 · Cited by 890
Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia
Picconi, B., Centonze, D., Håkansson, K., Bernardi, G., Greengard, P., Fisone, G., Cenci, M. A., & Calabresi, P. (2003) · Nature Neuroscience · doi:10.1038/nn1040 · Cited by 821
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815
Consensus: Motor cortex plasticity protocols
Ziemann, U., Paulus, W., Nitsche, M. A., Pascual-Leone, A., Byblow, W. D., Berardelli, A., Siebner, H. R., Classen, J., Cohen, L. G., & Rothwell, J. C. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.006 · Cited by 639
Self-citationKleim, J. A., Chan, S., Pringle, E., Schallert, K., Procaccio, V., Jimenez, R., & Cramer, S. C. (2006) · Nature Neuroscience · doi:10.1038/nn1699 · Cited by 529
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Cited by
Plasticity during stroke recovery: from synapse to behaviour
Murphy, T. H., & Corbett, D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2735 · Cited by 1,938
Plasticity in gray and white: neuroimaging changes in brain structure during learning
Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685
Fritsch, B., Reis, J., Martinowich, K., Schambra, H. M., Ji, Y., Cohen, L. G., & Lu, B. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.035 · Cited by 1,420
Inter-individual Variability in Response to Non-invasive Brain Stimulation Paradigms
López-Alonso, V., Cheeran, B., Río-Rodríguez, D., & Fernández-del-Olmo, M. (2014) · Brain Stimulation · doi:10.1016/j.brs.2014.02.004 · Cited by 810
Self-citationRidding, M. C., & Ziemann, U. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.190314 · Cited by 787
Metadata
- Authors
- Cheeran, B., Talelli, P., Mori, F., Koch, G., Suppa, A., Edwards, M., Houlden, H., Bhatia, K., Greenwood, R., & Rothwell, J. C.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2008-11-28
- Volume
- 586
- Issue
- 23
- Pages
- 5717-5725
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1693245692
- Cited by
- 705
- References
- 8
- FWCI
- 19.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A common polymorphism in the brain‐derived neurotrophic factor gene ( BDNF ) modulates human cortical plasticity and the response to rTMS. https://app.cochat.ai/papers/10.1113/jphysiol.2008.159905
- The paper
- Cheeran, B., Talelli, P., Mori, F., Koch, G., Suppa, A., Edwards, M., Houlden, H., Bhatia, K., Greenwood, R., & Rothwell, J. C. (2008). A common polymorphism in the brain‐derived neurotrophic factor gene ( BDNF ) modulates human cortical plasticity and the response to rTMS. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2008.159905
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