Cited by 322Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

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The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Medial Prefrontal Cortex in Autism

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Hashemi, Ezzat, Ariza, Jeanelle, Rogers, Haille, Noctor, Stephen C., Martínez-Cerdeño, Verónica·2016·Cerebral Cortex

DOI 10.1093/cercor/bhw021PMC PMC6074948

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Abstract

The cognitive phenotype of autism has been correlated with an altered balance of excitation to inhibition in the cerebral cortex, which could result from a change in the number, function, or morphology of GABA-expressing interneurons. The number of GABAergic interneuron subtypes has not been quantified in the autistic cerebral cortex. We classified interneurons into 3 subpopulations based on expression of the calcium-binding proteins parvalbumin, calbindin, or calretinin. We quantified the number of each interneuron subtype in postmortem neocortical tissue from 11 autistic cases and 10 control cases. Prefrontal Brodmann Areas (BA) BA46, BA47, and BA9 in autism and age-matched controls were analyzed by blinded researchers. We show that the number of parvalbumin+ interneurons in these 3 cortical areas-BA46, BA47, and BA9-is significantly reduced in autism compared with controls. The number of calbindin+ and calretinin+ interneurons did not differ in the cortical areas examined. Parvalbumin+ interneurons are fast-spiking cells that synchronize the activity of pyramidal cells through perisomatic and axo-axonic inhibition. The reduced number of parvalbumin+ interneurons could disrupt the balance of excitation/inhibition and alter gamma wave oscillations in the cerebral cortex of autistic subjects. These data will allow development of novel treatments specifically targeting parvalbumin interneurons.

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Authors: Hashemi, E., Ariza, J., Rogers, H., Noctor, S. C., & Martínez-Cerdeño, V.
Affiliations: Shriners Hospitals for Children - Northern California (US)
University of California Davis Medical Center (US)
ORCID: Hashemi, Ezzat
Noctor, Stephen C.
Venue: Cerebral Cortex
Publisher: Oxford University Press (OUP)
Published: 2016-02-27
Volume: 27
Issue: 2
Pages: bhw021
ISSN: 1047-3211 (ISSN-L)
1460-2199
DOI: 10.1093/cercor/bhw021
PMC: PMC6074948
OpenAlex: W2294392975
Cited by: 322
References: 113
Citations by year: 2026: 17 · 2025: 20 · 2024: 32 · 2023: 30 · 2022: 26 · 2021: 49 · 2020: 45 · 2019: 34 · 2018: 30 · 2017: 32 · 2016: 7
FWCI: 21.85
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cerebral Cortex (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute for Mental Health (MH094681 and MH101188)
MIND Institute (U54 HD079125)
Shriners Hospitals, and the Pathology Department at UCD
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: autism spectrum disorder, parvalbumin interneurons, GABAergic interneurons, medial prefrontal cortex, excitation-inhibition balance, interneuron subtypes, calbindin, calretinin, fast-spiking interneurons, gamma oscillations, postmortem brain
MeSH terms: Adolescent, Adult, Autistic Disorder, Cell Count, Child, Female, Humans, Interneurons, Male, Middle Aged, Parvalbumins, Calbindins, Calbindin 2

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The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Medial Prefrontal Cortex in Autism

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