Distinct Neocortical Progenitor Lineages Fine-tune Neuronal Diversity in a Layer-specific Manner.
Open accessAbstract
How the variety of neurons that organize into neocortical layers and functional areas arises is a central question in the study of cortical development. While both intrinsic and extrinsic cues are known to influence this process, whether distinct neuronal progenitor groups contribute to neuron diversity and allocation is poorly understood. Using in vivo genetic fate-mapping combined with whole-cell patch clamp recording, we show that the firing pattern and apical dendritic morphology of excitatory neurons in layer 4 of the barrel cortex are specified in part by their neural precursor lineage. Further, we show that separate precursors contribute to unique features of barrel cortex topography including the intralaminar position and thalamic innervation of the neurons they generate. Importantly, many of these lineage-specified characteristics are different from those previously measured for pyramidal neurons in layers 2-3 of the frontal cortex. Collectively, our data elucidate a dynamic temporal program in neuronal precursors that fine-tunes the properties of their progeny according to the lamina of destination.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Multiple classes of NPCs exist that result in numerous subtypes of neurons.
“Recent studies have identified multiple classes of NPCs that result in numerous subtypes of neurons even within a small defined region of the cortex (Tyler et al., 2015; Guillamon-Vivancos et al., 2019).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Guillamon-Vivancos et al., 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neurogenic radial glia in the outer subventricular zone of human neocortex
Hansen, D. V., Lui, J. H., Parker, P. R. L., & Kriegstein, A. R. (2010) · Nature · doi:10.1038/nature08845 · Cited by 1,388 · see citing works
Pollen, A. A., Nowakowski, T. J., Shuga, J., Wang, X., Leyrat, A. A., Lui, J. H., Li, N., Szpankowski, L., Fowler, B., Chen, P., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2967 · Cited by 920 · see citing works
Cell-cycle control and cortical development
Dehay, C., & Kennedy, H. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2097 · Cited by 655 · see citing works
Feldmeyer, D., Egger, V., Lübke, J., & Sakmann, B. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00169.x · Cited by 441 · see citing works
Excitatory neuronal connectivity in the barrel cortex
Feldmeyer, D. (2012) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2012.00024 · Cited by 298 · see citing works
Staiger, J. F. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh029 · Cited by 226 · see citing works
Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis
Kawaguchi, A., Ikawa, T., Kasukawa, T., Ueda, H. R., Kurimoto, K., Saitou, M., & Matsuzaki, F. (2008) · Development · doi:10.1242/dev.022616 · Cited by 193 · see citing works
Stancik, E. K., Navarro-Quiroga, I., Sellke, R., & Haydar, T. F. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6131-09.2010 · Cited by 186 · see citing works
Self-citationCortical and Clonal Contribution of Tbr2 Expressing Progenitors in the Developing Mouse Brain
Vasistha, N. A., García-Moreno, F., Arora, S., Cheung, A. F. P., Arnold, S. J., Robertson, E. J., & Molnár, Z. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu125 · Cited by 177 · see citing works
Callaway, E. M., & Borrell, V. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5222-10.2011 · Cited by 95 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Amatrudo JM, Weaver CM, Crimins JL, Hof PR, Rosene DL, Luebke JI. 2012. Influence of highly distinctive structural properties on the excitability of pyramidal neurons in mon- key visual and prefrontal cortices. J Neurosci. 32(40): 13644-13660.
- Crimins JL, Rocher AB, Luebke JI. 2012. Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progres- sive tauopathy. Acta Neuropathol. 122(5):551-564.
- Lund JS. 1984. Spiny Stellate Neurons. In: Peters A, Jones EG, editors. Cerebral cortex: cellular components of the cerebral cortex, Vol. 1. New York: Plenum Press, p. 255-308.
- Rocher AB, Crimins JL, Amatrudo JM, Kinson MS, Todd-Brown MA, Lewis J, Luebke JI. 2010. Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs. Exp Neurol. 223(2):385-393.
Cited by
Sorted by citations
Neurodevelopment in Down syndrome: Concordance in humans and models
Klein, J. A., & Haydar, T. F. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.941855 · Cited by 47 · see citing works
“Recent studies have identified multiple classes of NPCs that result in numerous subtypes of neurons even within a small defined region of the cortex (Tyler et al., 2015; Guillamon-Vivancos et al., 2019).”
BackgroundSelf-citation
- Authors
- Guillamon-Vivancos, T., Tyler, W. A., Medalla, M., Chang, W. W.-E., Okamoto, M., Haydar, T. F., & Luebke, J. I.
- Affiliations
- Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
- Boston University (US)
- Corresponding author
- Haydar, Tarik F
- Luebke, Jennifer I
- ORCID
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-02-03
- Volume
- 29
- Issue
- 3
- Pages
- 1121-1138
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC6373699
- OpenAlex
- W2791989763
- Cited by
- 34
- References
- 10
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neocortex development, neuronal heterogeneity, barrel cortex, layer 4, excitatory neurons, neuronal firing patterns, dendritic morphology, cortical topography, pyramidal neurons, frontal cortex, genetic fate mapping
- MeSH terms
- Action Potentials, Animals, Female, Male, Models, Neurological, Somatosensory Cortex, Pyramidal Cells, Neocortex, T-Box Domain Proteins, Dendritic Spines, Mice, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
