Excitatory neuronal connectivity in the barrel cortex

Feldmeyer, Dirk

doi:10.3389/fnana.2012.00024

Cited by 298Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchTactile and Sensory Interactions

Excitatory neuronal connectivity in the barrel cortex

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Feldmeyer, Dirk·2012·Frontiers in Neuroanatomy

DOI 10.3389/fnana.2012.00024PMC PMC3394394

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Abstract

Neocortical areas are believed to be organized into vertical modules, the cortical columns, and the horizontal layers 1-6. In the somatosensory barrel cortex these columns are defined by the readily discernible barrel structure in layer 4. Information processing in the neocortex occurs along vertical and horizontal axes, thereby linking individual barrel-related columns via axons running through the different cortical layers of the barrel cortex. Long-range signaling occurs within the neocortical layers but also through axons projecting through the white matter to other neocortical areas and subcortical brain regions. Because of the ease of identification of barrel-related columns, the rodent barrel cortex has become a prototypical system to study the interactions between different neuronal connections within a sensory cortical area and between this area and other cortical as well subcortical regions. Such interactions will be discussed specifically for the feed-forward and feedback loops between the somatosensory and the somatomotor cortices as well as the different thalamic nuclei. In addition, recent advances concerning the morphological characteristics of excitatory neurons and their impact on the synaptic connectivity patterns and signaling properties of neuronal microcircuits in the whisker-related somatosensory cortex will be reviewed. In this context, their relationship between the structural properties of barrel-related columns and their function as a module in vertical synaptic signaling in the whisker-related cortical areas will be discussed.

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Authors: Feldmeyer, D.
Affiliations: Forschungszentrum Jülich (DE)
Corresponding author: Feldmeyer, Dirk
ORCID: Feldmeyer, Dirk
Venue: Frontiers in Neuroanatomy
Publisher: Frontiers Media SA
Published: 2012
Volume: 6
Pages: 24-24
ISSN: 1662-5129 (ISSN-L)
DOI: 10.3389/fnana.2012.00024
PMC: PMC3394394
OpenAlex: W2156728993
Cited by: 298
References: 255
Citations by year: 2026: 16 · 2025: 15 · 2024: 15 · 2023: 19 · 2022: 16 · 2021: 31 · 2020: 26 · 2019: 25 · 2018: 25 · 2017: 23 · 2016: 24 · 2015: 23 · 2014: 25 · 2013: 14 · 2012: 1
FWCI: 10.31
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Neuroanatomy (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
JuSER (Forschungszentrum Jülich) (submittedVersion, other-oa)
RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
RWTH Publications (RWTH Aachen)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Keywords: barrel cortex, excitatory neurons, cortical columns, somatosensory cortex, somatomotor cortex, thalamic nuclei, neuronal microcircuits, neuronal morphology, synaptic connectivity

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Excitatory neuronal connectivity in the barrel cortex

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