Enduring behavioral effects induced by birth by caesarean section in the mouse
Open accessAbstract
Birth by Caesarean (C)-section impacts early gut microbiota colonization and is associated with an increased risk of developing immune and metabolic disorders. Moreover, alterations of the microbiome have been shown to affect neurodevelopmental trajectories. However, the long-term effects of C-section on neurobehavioral processes remain unknown. Here, we demonstrated that birth by C-section results in marked but transient changes in microbiome composition in the mouse, in particular, the abundance of Bifidobacterium spp. was depleted in early life. Mice born by C-section had enduring social, cognitive, and anxiety deficits in early life and adulthood. Interestingly, we found that these specific behavioral alterations induced by the mode of birth were also partially corrected by co-housing with vaginally born mice. Finally, we showed that supplementation from birth with a Bifidobacterium breve strain, or with a dietary prebiotic mixture that stimulates the growth of bifidobacteria, reverses selective behavioral alterations in C-section mice. Taken together, our data link the gut microbiota to behavioral alterations in C-section-born mice and suggest the possibility of developing adjunctive microbiota-targeted therapies that may help to avert long-term negative consequences on behavior associated with C-section birth mode.
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Microbial alterations associated with C-section delivery could have permanent effects on behavior and cognition.
“These microbial alterations (e.g., depletion in Bifidobacterium) associated with C-section delivery could have permanent effects on behavior and cognition;”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [251]
Some microbial and behavioral alterations associated with C-section could be reversed by supplementation with a prebiotic mixture (galactooligosaccharide, fructooligosaccharide), suggesting that microbiota-targeted diet interventions could be used to alleviate some of the negative effects associated with C-section.
“however, some of these microbial and behavioral alterations could be reversed by supplementation with a prebiotic mixture (galactooligosaccharide, fructooligosaccharide), suggesting that microbiota-targeted diet interventions could be used to alleviate some of the negative effects associated with Csection (251).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [251]
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Palacios‐García, I., Mhuireach, G. A., Grasso‐Cladera, A., Cryan, J. F., & Parada, F. J. (2022) · BioEssays · doi:10.1002/bies.202100249 · Cited by 14 · see citing works
Self-citation
- Authors
- Morais, L. H., Golubeva, A. V., Moloney, G. M., Moya-Pérez, A., Ventura-Silva, A. P., Arboleya, S., Bastiaanssen, T. F. S., O’Sullivan, O., Rea, K., Borre, Y., Scott, K. A., Patterson, E., Cherry, P., Stilling, R., Hoban, A. E., El Aidy, S., Sequeira, A. M., Beers, S., Moloney, R. D., Renes, I. B., Wang, S., Knol, J., Ross, R. P., O’Toole, P. W., Cotter, P. D., Stanton, C., Dinan, T. G., & Cryan, J. F.
- Affiliations
- University College Cork (IE)
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- Amsterdam UMC Location University of Amsterdam (NL)
- Nutricia Research (Netherlands) (NL)
- Corresponding author
- Cryan, John F.
- ORCID
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 30
- Issue
- 19
- Pages
- 3761-3774.e6
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W3078809481
- Cited by
- 104
- References
- 80
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 15 · 2023: 12 · 2022: 18 · 2021: 29 · 2020: 5
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by-nc-nd)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by-nc-nd)
- T-Stór (Teagasc) (acceptedVersion, cc-by-nc-sa)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion, cc-by-nc-nd)
- T-Stór (Teagasc) (submittedVersion, cc-by-nc-sa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc-nd)
- Funders
- Danone Nutricia Research
- Science Foundation Ireland
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- cesarean section, gut microbiota, Bifidobacterium, Bifidobacterium breve, social behavior, anxiety, cognitive impairment, cohousing, prebiotics, microbiota-targeted therapy, mode of delivery, neurobehavioral development
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bifidobacterium, Cesarean Section, Disease Models, Animal, Feces, Female, Nervous System Diseases, Pregnancy, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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