Surfactant-Assisted Pressurized Liquid Extraction at Room Temperature for Radix glycyrrhizae by a New Class of Surfactants
Open accessAbstract
A laboratory-assembled surfactant-assisted pressurized liquid extraction system at room temperature was used for the extraction of glycyrrhizin (GLY) in Radix glycyrrhizae. Environmentally friendly saccharide fatty acid ester such as glucose oleic acid ester is proposed to replace chemical-based surfactants. As the chemical properties of the surfactant obtained were unknown initially, lipase-catalyzed synthesis and liquid chromatography with tandem mass spectrometry were used to ascertain the identity. Surfactant-assisted pressurized liquid extraction (PLE) was carried out dynamically and the extraction efficiencies of the proposed method using different concentration of glucose oleic acid ester were compared with sonication using an organic solvent (ethanol/water, 70:30). The extraction efficiencies of GLY in Radix glycyrrhizae using surfactant-assisted PLE was observed to be higher compared with sonication. The method precision was found to vary from 1.3 to 5.1% (relative standard deviation, RSD, n= 6) on different days. The new method demonstrated the possibility for the extraction to be carried out at room temperature for the production of botanical extracts.
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“As is known, surfactants are both hydrophilic and lipophilic compounds which make them unique tools in isolation of various natural compounds via extraction processes (22-30).”
Background
- Authors
- Heng, M. Y., Thio, B. J. R., & Ong, E. S.
- Affiliations
- Singapore University of Technology and Design (SG)
- Corresponding author
- Ong, Eng Shi
- Venue
- Journal of Chromatographic Science
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-03-02
- Volume
- 54
- Issue
- 5
- Pages
- 864-870
- ISSN
- 0021-9665 (ISSN-L)
- 1945-239X
- PMC
- PMC4890455
- OpenAlex
- W2294220935
- Cited by
- 4
- References
- 19
- Citations by year
- 2026: 2 · 2021: 1 · 2020: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Chromatographic Science (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- SUTD-MIT International Design Centre
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Phase Equilibria and Thermodynamics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
- Keywords
- room temperature extraction, Radix Glycyrrhizae, glycyrrhizin, lipase-catalyzed synthesis, ultrasound-assisted extraction, extraction efficiency
- MeSH terms
- Chromatography, High Pressure Liquid, Plant Extracts, Pressure, Reference Standards, Surface-Active Agents, Tandem Mass Spectrometry
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