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Cited by 473

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study

Open access
Bartoletti, Michele, Pascale, Renato, Cricca, Monica, Rinaldi, Matteo, Maccaro, Angelo, Bussini, Linda, Fornaro, Giacomo, Tonetti, Tommaso, Pizzilli, Giacinto, Francalanci, Eugenia, Giuntoli, Lorenzo, Rubin, Arianna, Moroni, Alessandra, Ambretti, Simone, Trapani, Filippo, Vatamanu, Oana, Ranieri, Vito Marco, Castelli, Andrea, Baiocchi, Massimo, Lewis, Russell, Giannella, Maddalena, Viale, Pierluigi, PREDICO Study Group, Raumer, Luigi, Guerra, Luca, Tumietto, Fabio, Cascavilla, Alessandra, Zamparini, Eleonora, Verucchi, Gabriella, Coladonato, Simona, Ianniruberto, Stefano, Attard, Luciano, Volpato, Marina Tadolini Francesca, Virgili, Giulio, Rossi, Nicolò, Del Turco, Elena Rosselli, Guardigni, Viola, Fasulo, Giovanni, Dentale, Nicola, Fulgaro, Ciro, Legnani, Giorgio, Campaci, Emanuele, Basso, Cristina, Zuppiroli, Alberto, Passino, Amalia Sanna, Tesini, Giulia, Angelelli, Lucia, Badeanu, Adriana, Rossi, Agostino, Santangelo, Giulia, Dauti, Flovia, Koprivika, Vidak, Roncagli, Nicholas, Tzimas, Ioannis, Liuzzi, Guido Maria, Baxhaku, Irid, Pasinelli, Letizia, Neri, Mattia, Zanaboni, Tommaso, Dell’Omo, Francesco, Gori, Alice, Zavatta, Idina, Antonini, Stefano, Pironi, Chiara, Piccini, Elena, Esposito, Luca, Zuccotti, Alessandro, Urbinati, Giacomo, Pratelli, Agnese, Sarti, Alberto, Semprini, Michela, Evangelisti, Enrico, D’Onofrio, Mara, Sasdelli, Giuseppe·2021·Clinical Infectious Diseases
DOI 10.1093/cid/ciaa1065
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Abstract

Background: We evaluated the incidence of invasive pulmonary aspergillosis among intubated patients with critical COVID-19 and evaluated different case definitions of invasive aspergillosis. Methods: Prospective, multicenter study in adult patients with microbiologically confirmed COVID-19 receiving mechanical ventilation. All included participants underwent a screening protocol for invasive pulmonary aspergillosis with bronchoalveolar lavage galactomannan and cultures performed on admission at 7 days and in case of clinical deterioration. Cases were classified as coronavirus-associated pulmonary aspergillosis (CAPA) according to previous consensus definitions. The new definition was compared with putative invasive pulmonary aspergillosis (PIPA). Results: 108 patients were enrolled. Probable CAPA was diagnosed in 30 (27.7%) patients after a median of 4 (2–8) days from intensive care unit (ICU) admission. Kaplan-Meier curves showed a significantly higher 30-day mortality rate from ICU admission among patients with either CAPA (44% vs 19%, P = .002) or PIPA (74% vs 26%, P < .001) when compared with patients not fulfilling criteria for aspergillosis. The association between CAPA (OR, 3.53; 95% CI, 1.29–9.67; P = .014) or PIPA (OR, 11.60; 95% CI, 3.24–41.29; P < .001) with 30-day mortality from ICU admission was confirmed, even after adjustment for confounders with a logistic regression model. Among patients with CAPA receiving voriconazole treatment (13 patients; 43%) a trend toward lower mortality (46% vs 59%; P = .30) and reduction in galactomannan index in consecutive samples were observed. Conclusions: We found a high incidence of CAPA among critically ill COVID-19 patients and its occurrence seems to change the natural course of disease.

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Authors
Bartoletti, M., Pascale, R., Cricca, M., Rinaldi, M., Maccaro, A., Bussini, L., Fornaro, G., Tonetti, T., Pizzilli, G., Francalanci, E., Giuntoli, L., Rubin, A., Moroni, A., Ambretti, S., Trapani, F., Vatamanu, O., Ranieri, V. M., Castelli, A., Baiocchi, M., Lewis, R., Giannella, M., Viale, P., PREDICO Study Group, Raumer, L., Guerra, L., Tumietto, F., Cascavilla, A., Zamparini, E., Verucchi, G., Coladonato, S., Ianniruberto, S., Attard, L., Volpato, M. T. F., Virgili, G., Rossi, N., Del Turco, E. R., Guardigni, V., Fasulo, G., Dentale, N., Fulgaro, C., Legnani, G., Campaci, E., Basso, C., Zuppiroli, A., Passino, A. S., Tesini, G., Angelelli, L., Badeanu, A., Rossi, A., Santangelo, G., Dauti, F., Koprivika, V., Roncagli, N., Tzimas, I., Liuzzi, G. M., Baxhaku, I., Pasinelli, L., Neri, M., Zanaboni, T., Dell’Omo, F., Gori, A., Zavatta, I., Antonini, S., Pironi, C., Piccini, E., Esposito, L., Zuccotti, A., Urbinati, G., Pratelli, A., Sarti, A., Semprini, M., Evangelisti, E., D’Onofrio, M., & Sasdelli, G.
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2020-07-28
Volume
73
Issue
11
Pages
e3606-e3614
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1093/cid/ciaa1065
OpenAlex
W3046139360
Cited by
473
References
7
FWCI
10.74
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study. https://app.cochat.ai/papers/10.1093/cid/ciaa1065
The paper
Bartoletti, M., Pascale, R., Cricca, M., Rinaldi, M., Maccaro, A., Bussini, L., Fornaro, G., Tonetti, T., Pizzilli, G., Francalanci, E., Giuntoli, L., Rubin, A., Moroni, A., Ambretti, S., Trapani, F., Vatamanu, O., Ranieri, V. M., Castelli, A., Baiocchi, M., . . . Sasdelli, G. (2021). Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaa1065

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.