Use of Antistaphylococcal -Lactams to Increase Daptomycin Activity in Eradicating Persistent Bacteremia Due to Methicillin-Resistant Staphylococcus aureus: Role of Enhanced Daptomycin Binding
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We used daptomycin plus antistaphylococcal β-lactams (ASBL) to clear refractory MRSA bacteremia. In vitro studies showed enhanced daptomycin bactericidal activity, increased membrane daptomycin binding, and decrease in positive surface charge induced by ASBLs against daptomycin nonsusceptible MRSA. Addition of ASBLs to daptomycin may be of benefit in refractory MRSA bacteremia. (Although the official designation is "daptomycin nonsusceptiblity," we will use the term "daptomycin-resistance" in this paper for facility of presentation.).
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The combination of daptomycin and a beta-lactam antibiotic has been reported to be effective in treating a limited number of patients with persistent MRSA bacteremia.
“The combination of daptomycin and a β-lactam antibiotic has been reported to be effective in treating a limited number of patients with persistent MRSA bacteremia.168”
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- Authors
- Dhand, A., Bayer, A. S., Pogliano, J., Yang, S.-J., Bolaris, M., Nizet, V., Wang, G., & Sakoulas, G.
- Affiliations
- New York Medical College (US)
- University of California, Los Angeles (US)
- University of California San Diego (US)
- Sharp Memorial Hospital (US)
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-20
- Volume
- 53
- Issue
- 2
- Pages
- 158-163
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- PMC
- PMC3697476
- OpenAlex
- W2168625432
- Cited by
- 252
- References
- 12
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 9 · 2023: 13 · 2022: 11 · 2021: 12 · 2020: 16 · 2019: 19 · 2018: 19 · 2017: 19 · 2016: 20 · 2015: 31 · 2014: 23 · 2013: 20 · 2012: 21
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Infectious Diseases (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Sharp HealthCare
- Astellas Pharma
- Pfizer Pharmaceuticals
- National Institute of General Medical Sciences (R01GM073898)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Keywords
- daptomycin, methicillin-resistant Staphylococcus aureus, MRSA bacteremia, persistent bacteremia, daptomycin resistance, membrane binding, bactericidal activity, combination therapy
- MeSH terms
- Adult, Aged, 80 and over, Anti-Bacterial Agents, Cell Membrane, Drug Therapy, Combination, Female, Humans, Male, Membrane Potentials, Microbial Sensitivity Tests, Middle Aged, Bacteremia, Treatment Outcome, Daptomycin, Drug Resistance, Bacterial, beta-Lactams, Methicillin-Resistant Staphylococcus aureus
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