MRSA: the first half century

Moellering, R. C.

doi:10.1093/jac/dkr437

Cited by 236Antimicrobial Resistance in StaphylococcusAntibiotic Use and ResistanceInfection Control in Healthcare

MRSA: the first half century

Moellering, R. C.·2012·Journal of Antimicrobial Chemotherapy

DOI 10.1093/jac/dkr437

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Abstract

Fifty years ago methicillin-resistant Staphylococcus aureus (MRSA) first revealed themselves to the medical community, having been described in a landmark article published in the British Medical Journal. Among other things, their discovery set off a major response from the scientific and medical professions to control or even eliminate them as major human pathogens. Despite these efforts, however, MRSA have spread throughout the world and a half century after they burst upon the scene they continue to pose major challenges to research scientists and clinicians alike. In a very real sense, this year marks the 'birthday' of a remarkably successful pathogen. The major reasons for the ability of MRSA to prosper and cause disease in settings inimical to its survival form the basis of this article.

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To date, 11 different SCCmec allotypes have been described with varying degrees of genetic homology and different sizes, insertion sequences and accompanying resistance genes.
“To date, 11 different SCCmec allotypes have been described with varying degrees of genetic homology and different sizes, insertion sequences and accompanying resistance genes (68, 69).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [69]

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Authors: Moellering, R. C.
Affiliations: Beth Israel Deaconess Medical Center (US)
Corresponding author: Moellering, R. C.
Venue: Journal of Antimicrobial Chemotherapy
Publisher: Oxford University Press (OUP)
Published: 2011-10-18
Volume: 67
Issue: 1
Pages: 4-11
ISSN: 0305-7453 (ISSN-L)
1460-2091
DOI: 10.1093/jac/dkr437
OpenAlex: W2101650905
Cited by: 236
References: 75
Citations by year: 2026: 8 · 2025: 13 · 2024: 11 · 2023: 7 · 2022: 8 · 2021: 21 · 2020: 9 · 2019: 17 · 2018: 13 · 2017: 20 · 2016: 28 · 2015: 33 · 2014: 23 · 2013: 17 · 2012: 8
FWCI: 1.95
Type: journal article
Language: en
Open access: closed
Locations: Journal of Antimicrobial Chemotherapy (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
Keywords: methicillin-resistant Staphylococcus aureus, antibiotic resistance, bacterial virulence, pathogen adaptation, staphylococcal infections, antimicrobial resistance control
MeSH terms: Humans, Staphylococcal Infections, Drug Resistance, Multiple, Bacterial, History, 20th Century, History, 21st Century, Methicillin-Resistant Staphylococcus aureus, Pandemics

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