Cited by 218Antifungal resistance and susceptibilityOcular Infections and TreatmentsInfective Endocarditis Diagnosis and Management

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Ocular Manifestations of Candidemia

Open access

Oude Lashof, A. M. L., Rothova, A., Sobel, J. D., Ruhnke, M., Pappas, P. G., Viscoli, C., Schlamm, H. T., Oborska, I. T., Rex, J. H., Kullberg, B. J.·2011·Clinical Infectious Diseases

DOI 10.1093/cid/cir355

Open this paper in CoChat — free account

Abstract

BACKGROUND: Ocular candidiasis is a major complication of candidemia. The incidence, risk factors, and outcome of eye involvement during candidemia are largely unknown. We prospectively studied the ocular manifestations of candidemia in a large, worldwide, randomized multicenter trial that compared voriconazole with amphotericin B followed by fluconazole for the treatment of candidemia. METHODS: Nonneutropenic patients with blood cultures positive for Candida species were assigned treatment with voriconazole or with amphotericin B followed by fluconazole in a randomized 2:1 ratio. Dilated fundoscopy was performed in each patient at baseline, on day 7, at 2 and 6 weeks after the end of treatment (EOT), and, if clinically indicated, at 12 weeks after EOT. RESULTS: Of 370 patients, 49 had findings consistent with the diagnosis of ocular candidiasis at baseline, and an additional 11 patients developed abnormalities during treatment, totaling 60 patients with eye involvement (16%). Of these patients, probable Candida eye infection was diagnosed in 40 patients (6 with endophthalmitis, 34 with chorioretinitis), and possible Candida eye infection in 20 (all with chorioretinitis). The duration of candidemia was significantly longer in patients with ocular candidiasis (median, 4 days; range, 1-18 days) compared with patients without ocular involvement (median, 3 days; range 1-26 days; log rank, P = .026). Therapy with either voriconazole (44 cases) or amphotericin B followed by fluconazole (16 cases) was successful in 65% of patients; outcome was not evaluable in 32% and was unfavorable in 3%. CONCLUSIONS: Ocular involvement occurred in 16% of patients with candidemia; however, endophthalmitis was uncommon (1.6%). Treatment with either voriconazole or amphotericin B followed by fluconazole was successful for ocular candidiasis in most cases with follow-up.

Integrity signals

Registry

Crossref · 10.1093/cid/cir355

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of America
Pappas, P. G., Kauffman, C. A., Andes, D., Benjamin, D. K., Calandra, T. F., Edwards, J. E., Filler, S. G., Fisher, J. F., Kullberg, B.-J., Zeichner, L. O., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/596757 · Cited by 3,191
Self-citation
Comparison of Caspofungin and Amphotericin B for Invasive Candidiasis
Mora-Duarte, J., Betts, R., Rotstein, C., Colombo, A. L., Thompson-Moya, L., Smietana, J., Lupinacci, R., Sable, C., Kartsonis, N., & Perfect, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021585 · Cited by 1,380
Anidulafungin versus Fluconazole for Invasive Candidiasis
Reboli, A. C., Rotstein, C., Pappas, P. G., Chapman, S. W., Kett, D. H., Kumar, D., Betts, R., Wible, M., Goldstein, B. P., Schranz, J., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066906 · Cited by 894
Self-citation
Candida parapsilosis , an Emerging Fungal Pathogen
Trofa, D. P., Gácser, A., & Nosanchuk, J. D. (2008) · Clinical Microbiology Reviews · doi:10.1128/cmr.00013-08 · Cited by 886
Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trial
Kuse, E.-R., Chetchotisakd, P., da Cunha, C. A., Ruhnke, M., Barrios, C., Raghunadharao, D., Sekhon, J. S., Freire, A., Ramasubramanian, V., Demeyer, I., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60605-9 · Cited by 692
Self-citation
Micafungin versus Caspofungin for Treatment of Candidemia and Other Forms of Invasive Candidiasis
Pappas, P. G., Rotstein, C. M. F., Betts, R. F., Nucci, M., Talwar, D., De Waele, J. J., Vazquez, J. A., Dupont, B. F., Horn, D. L., Ostrosky-Zeichner, L., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/520980 · Cited by 638
Voriconazole versus a regimen of amphotericin B followed by fluconazole for candidaemia in non-neutropenic patients: a randomised non-inferiority trial
Kullberg, B., Sobel, J., Ruhnke, M., Pappas, P., Viscoli, C., Rex, J., Cleary, J., Rubinstein, E., Church, L., Brown, J., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67490-9 · Cited by 521
Determination of Vitreous, Aqueous, and Plasma Concentration of OrallyAdministered Voriconazole in Humans
Hariprasad, S. M. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.1.42 · Cited by 312
Intraocular Candidiasis in Patients with Candidemia
Donahue, S. P., Greven, C. M., Zuravleff, J. J., Eller, A. W., Nguyen, M. H., Peacock, J. E., Wagener, M. M., & Yu, V. L. (1994) · Ophthalmology · doi:10.1016/s0161-6420(94)31175-4 · Cited by 239
A Multicenter, Double‐Blind Trial of a High‐Dose Caspofungin Treatment Regimen versus a Standard Caspofungin Treatment Regimen for Adult Patients with Invasive Candidiasis
Betts, R. F., Nucci, M., Talwar, D., Gareca, M., Queiroz‐Telles, F., Bedimo, R. J., Herbrecht, R., Ruiz‐Palacios, G., Young, J. H., Baddley, J. W., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/598933 · Cited by 214

Flagged first, then by citations

Show all 29 references

Research works printed but not linked: 1

Rodr guez-Adri n, 2003, Medicine, 82, 187

Sorted by citations

Invasive candidiasis
Pappas, P. G., Lionakis, M. S., Arendrup, M. C., Ostrosky-Zeichner, L., & Kullberg, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.26 · Cited by 1,636
ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients
Cornely, O. A., Bassetti, M., Calandra, T., Garbino, J., Kullberg, B. J., Lortholary, O., Meersseman, W., Akova, M., Arendrup, M. C., Arikan-Akdagli, S., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12039 · Cited by 1,217
Bacterial and Fungal Endophthalmitis
Durand, M. L. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00113-16 · Cited by 526
Endophthalmitis
Durand, M. L. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12118 · Cited by 519
An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells
Leger, A. J. S., Desai, J. V., Drummond, R. A., Kugadas, A., Almaghrabi, F., Silver, P. B., Raychaudhuri, K., Gadjeva, M. G., Iwakura, Y., Lionakis, M. S., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.014 · Cited by 292
Invasive Candidiasis
McCarty, T. P., & Pappas, P. G. (2016) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.10.013 · Cited by 285
Candidemia and Invasive Candidiasis
McCarty, T. P., White, C. M., & Pappas, P. G. (2021) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2021.03.007 · Cited by 260
Candidemia and invasive candidiasis in adults: A narrative review
Antinori, S., Milazzo, L., Sollima, S., Galli, M., & Corbellino, M. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.06.029 · Cited by 259
Common invasive fungal diseases: an overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia
Schmiedel, Y., & Zimmerli, S. (2016) · Swiss Medical Weekly · doi:10.4414/smw.2016.14281 · Cited by 232
Endogenous endophthalmitis: diagnosis, management, and prognosis
Sadiq, M. A., Hassan, M., Agarwal, A. K., Sarwar, S., Toufeeq, S., Soliman, M. K., Hanout, M., Sepah, Y. J., Diana, V., & Nguyen, Q. D. (2015) · Journal of Ophthalmic Inflammation and Infection · doi:10.1186/s12348-015-0063-y · Cited by 218
Invasive candidiasis: current clinical challenges and unmet needs in adult populations
Soriano, À., Honoré, P. M., Puerta‐Alcalde, P., García‐Vidal, C., Pagotto, A., Gonçalves, D. C., & Verweij, P. E. (2023) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkad139 · Cited by 215
Medical interventions for fungal keratitis
FlorCruz, N. V., & Evans, J. R. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004241.pub4 · Cited by 176
Brazilian guidelines for the management of candidiasis – a joint meeting report of three medical societies: Sociedade Brasileira de Infectologia, Sociedade Paulista de Infectologia and Sociedade Brasileira de Medicina Tropical
Colombo, A. L., Guimarães, T., Camargo, L. F. A., Richtmann, R., Queiroz‐Telles, F., Salles, M. J. C., da Cunha, C. A., Shikanai‐Yasuda, M. A., Moretti, M. L., & Nucci, M. (2013) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2013.02.001 · Cited by 161
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Thompson, G. R., Jenks, J. D., Baddley, J. W., Lewis, J. S., Egger, M., Schwartz, I. S., Boyer, J., Patterson, T. F., Chen, S. C. ‐., Pappas, P. G., et al. (2023) · Clinical Microbiology Reviews · doi:10.1128/cmr.00019-23 · Cited by 132
Endogenous fungal endophthalmitis: risk factors, clinical features, and treatment outcomes in mold and yeast infections
Sridhar, J. S., Flynn, H. W., Kuriyan, A. E., Miller, D., & Albini, T. A. (2013) · Journal of Ophthalmic Inflammation and Infection · doi:10.1186/1869-5760-3-60 · Cited by 112
Treatment of Invasive Candidiasis: A Narrative Review
Ben-Ami, R. (2018) · Journal of Fungi · doi:10.3390/jof4030097 · Cited by 111
The Mycobiome in Health and Disease: Emerging Concepts, Methodologies and Challenges
Tiew, P. Y., Aogáin, M. M., Ali, N. A. B. M., Thng, K. X., Goh, K., Lau, K. J. X., & Chotirmall, S. H. (2020) · Mycopathologia · doi:10.1007/s11046-019-00413-z · Cited by 113
Value of β-d-glucan and Candida albicans germ tube antibody for discriminating between Candida colonization and invasive candidiasis in patients with severe abdominal conditions
León, C., Ruiz‐Santana, S., Saavedra, P., Castro, C., Úbeda, A., Loza, A., Martín‐Mazuelos, E., Blanco, A., Jerez, V., Ballús, J., et al. (2012) · Intensive Care Medicine · doi:10.1007/s00134-012-2616-y · Cited by 96
Utility of Ophthalmologic Screening for Patients With Candida Bloodstream Infections
Breazzano, M. P., Day, H. R., Bloch, K. C., Tanaka, S., Cherney, E. F., Sternberg, P. W., Donahue, S. P., & Bond, J. B. (2019) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2019.0733 · Cited by 98
Endogenous Endophthalmitis: A Review of Case Series Published between 2011 and 2020
Danielescu, C., Anton, N., Stanca, H. T., & Munteanu, M. (2020) · Journal of Ophthalmology · doi:10.1155/2020/8869590 · Cited by 85
American Academy of Ophthalmology Recommendations on Screening for Endogenous Candida Endophthalmitis
Breazzano, M. P., Bond, J. B., Bearelly, S., Kim, D. H., Donahue, S. P., Lum, F., & Olsen, T. W. (2021) · Ophthalmology · doi:10.1016/j.ophtha.2021.07.015 · Cited by 82
Invasive fungal infections in patients with cancer in the Intensive Care Unit
Sipsas, N. V., & Kontoyiannis, D. P. (2012) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2011.11.017 · Cited by 82
Mucoadhesive phenylboronic acid conjugated chitosan oligosaccharide-vitamin E copolymer for topical ocular delivery of voriconazole: synthesis, in vitro/vivo evaluation, and mechanism
Sun, X., Sheng, Y., Li, K., Sai, S., Feng, J., Li, Y., Zhang, J., Han, J., & Tian, B. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.10.047 · Cited by 79
Consensus guidelines for the treatment of yeast infections in the haematology, oncology and intensive care setting, 2014
Chen, S. C., Sorrell, T. C., Chang, C. C., Paige, E. K., Bryant, P. A., & Slavin, M. A. (2014) · Internal Medicine Journal · doi:10.1111/imj.12597 · Cited by 81
Occurrence, presentation and treatment of candidemia
Mikulska, M., Del Bono, V., Ratto, S., & Viscoli, C. (2012) · Expert Review of Clinical Immunology · doi:10.1586/eci.12.52 · Cited by 71
Eye Infections
Durand, M. L., Barshak, M. B., & Sobrin, L. (2023) · New England Journal of Medicine · doi:10.1056/nejmra2216081 · Cited by 69
Management bundles for candidaemia: the impact of compliance on clinical outcomes
Takesue, Y., Ueda, T., Mikamo, H., Oda, S., Takakura, S., Kitagawa, Y., KOHNO, S., on behalf of the ACTIONs Project, Masuda, A., Yoshida, C., et al. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku414 · Cited by 71
Consensus guidelines for the diagnosis and management of invasive candidiasis in haematology, oncology and intensive care settings, 2021
Keighley, C., Cooley, L., Morris, A. J., Ritchie, D., Clark, J. E., Boan, P., & Worth, L. J. (2021) · Internal Medicine Journal · doi:10.1111/imj.15589 · Cited by 66
Candidemia in the Intensive Care Unit
Epelbaum, O., & Chasan, R. (2017) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2017.04.010 · Cited by 67
Endophthalmitis: A review of recent trends
Safneck, J. R. (2012) · Saudi Journal of Ophthalmology · doi:10.1016/j.sjopt.2012.02.011 · Cited by 62
Eye fungal infections: a mini review
Reginatto, P., Agostinetto, G. D. J., Fuentefria, R. D. N., Marinho, D. R., Pizzol, M. M. D., & Fuentefría, A. M. (2023) · Archives of Microbiology · doi:10.1007/s00203-023-03536-6 · Cited by 56
Candidaemia and a risk predictive model for overall mortality: a prospective multicentre study
Keighley, C., Chen, S. C. A., Marriott, D. J. E., Pope, A. L., Chapman, B., Kennedy, K., Bak, N., Underwood, N., Wilson, H. L., McDonald, K., et al. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-4065-5 · Cited by 52
Prevalence of, and risk factors for, hematogenous fungal endophthalmitis in patients with Candida bloodstream infection
Kato, H., Yoshimura, Y., Suido, Y., Ide, K., Sugiyama, Y., Matsuno, K., & Nakajima, H. (2018) · Infection · doi:10.1007/s15010-018-1163-z · Cited by 51
Diagnosis of Invasive Candidiasis: From Gold Standard Methods to Promising Leading-edge Technologies
Pitarch, A., Nombela, C., & Gil, C. (2018) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026618666181025093146 · Cited by 51
The incidence of endophthalmitis or macular involvement and the necessity of a routine ophthalmic examination in patients with candidemia
Ueda, T., Takesue, Y., Tokimatsu, I., Miyazaki, T., Nakada, N., Nagao, M., Nakajima, K., Mikamo, H., Yamagishi, Y., Kasahara, K., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216956 · Cited by 48
Clinical characteristics and risk factors of ocular candidiasis
Nagao, M., Saito, T., Doi, S., Hotta, G., Yamamoto, M., Matsumura, Y., Matsushima, A., Ito, Y., Takakura, S., & Ichiyama, S. (2012) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2012.03.006 · Cited by 49
Prevalence of Ocular Candidiasis and Candida Endophthalmitis in Patients With Candidemia: A Systematic Review and Meta-Analysis
Phongkhun, K., Pothikamjorn, T. L., Srisurapanont, K., Manothummetha, K., Sanguankeo, A., Thongkam, A., Chuleerarux, N., Leksuwankun, S., Meejun, T., Thanakitcharu, J., et al. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad064 · Cited by 50
Invasive candidiasis: from mycobiome to infection, therapy, and prevention
Lagunes, L., & Rello, J. (2016) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-016-2658-0 · Cited by 47
Candidemia in a Portuguese tertiary care hospital: Analysis of a 2-year period
Pinto-Magalhães, S., Martins, A., Lacerda, S., Filipe, R., Prista‐Leão, B., Pinheiro, D., Silva‐Pinto, A., & Santos, L. (2019) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2019.08.002 · Cited by 43
Is routine ophthalmoscopy really necessary in candidemic patients?
Vena, A., Muñóz, P., Padilla, B., Valerio, M., Sanchez, M. I., Puig‐Asensio, M., Fortün, J., Fernández‐Ruiz, M., Merino, P., Losa, J. E., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183485 · Cited by 42
An Italian consensus for invasive candidiasis management (ITALIC)
Scudeller, L., Viscoli, C., Menichetti, F., Bono, V. D., Cristini, F., Tascini, C., Bassetti, M., & Viale, P. (2013) · Infection · doi:10.1007/s15010-013-0558-0 · Cited by 42
T2MR contributes to the very early diagnosis of complicated candidaemia. A prospective study
Muñóz, P., Vena, A., Machado, M., Martínez‐Jiménez, M. D. C., Gioia, F., Gómez, E., Origüen, J., Orellana, M. Á., López‐Medrano, F., Pérez-Granda, M. J., et al. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky048 · Cited by 41
Usefulness of EQUAL Candida Score for predicting outcomes in patients with candidaemia: a retrospective cohort study
Huang, H., Lu, P., Wang, Y., Chen, T., Chang, K., & Lin, S. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.01.029 · Cited by 41
Posaconazole micelles for ocular delivery: in vitro permeation, ocular irritation and antifungal activity studies
Durgun, M. E., Kahraman, E., Hacıoğlu, M., Güngör, S., & Özsoy, Y. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00974-x · Cited by 42
Inpatient Ophthalmology Consultation for Fungemia: Prevalence of Ocular Involvement and Necessity of Funduscopic Screening
Adam, M. K., Vahedi, S., Nichols, M., Fintelmann, R. E., Keenan, J. D., Garg, S. J., Hsu, J., Maguire, J. I., & Spirn, M. J. (2015) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2015.07.033 · Cited by 39
Risk factors and outcomes of patients with ocular involvement of candidemia
Son, H., Kim, M. J., Lee, S., Choi, S., Jung, K. H., Jung, J., Chong, Y. P., Kim, S., Choi, S., Kim, Y. S., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222356 · Cited by 40
Usefulness of guideline recommendations for prognosis in patients with candidemia
Cuervo, G., García‐Vidal, C., Puig‐Asensio, M., Merino, P., Vena, A., Martín‐Peña, A., Montejo, J. M., Gaitán, A. C. R., Lázaro-Perona, F., Fortün, J., et al. (2018) · Medical Mycology · doi:10.1093/mmy/myy118 · Cited by 36
Management of invasive candidiasis and candidaemia in critically ill adults: expert opinion of the European Society of Anaesthesia Intensive Care Scientific Subcommittee
O’Leary, R., Einav, S., Léone, M., Madách, K., Martin, C., & Martín‐Loeches, I. (2017) · Journal of Hospital Infection · doi:10.1016/j.jhin.2017.11.020 · Cited by 34
Chronic Meningitis
Thakur, K. T., & Wilson, M. R. (2018) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000664 · Cited by 35
Do all candidemic patients need an ophthalmic examination?
Vinikoor, M. J., Zoghby, J., Cohen, K. L., & Tucker, J. D. (2013) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2012.12.014 · Cited by 31
Endogenous Endophthalmitis - A Major Review
Xie, C. A., Singh, J., Tyagi, M., Androudi, S. N., Dave, V. P., Arora, A., Gupta, V., Agrawal, R. V., Mi, H. F., & Sen, A. C. (2022) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2022.2126863 · Cited by 31
Multimodal imaging of refractory Candida chorioretinitis progressing to endogenous endophthalmitis
Lavine, J. A., & Mititelu, M. (2015) · Journal of Ophthalmic Inflammation and Infection · doi:10.1186/s12348-015-0054-z · Cited by 30
Our 2014 approach to candidaemia
Koehler, P. A., Tacke, D., & Cornely, O. A. (2014) · Mycoses · doi:10.1111/myc.12207 · Cited by 30
An evidence-based bundle improves the quality of care and outcomes of patients with candidaemia
Cardozo, C., Cuervo, G., Salavert, M., Merino, P., Gioia, F., Fernández‐Ruiz, M., López-Cortés, L. E., Escolà‐Vergé, L., Montejo, M., Muñóz, P., et al. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz491 · Cited by 29
The efficacy of voriconazole in 24 ocular Fusarium infections
Troke, P. F., Obenga, G., Gaujoux, T., Goldschmidt, P. L., Bienvenu, A., Cornet, M., Grenouillet, F., Pons, D., Ranque, S., Sitbon, K., et al. (2012) · Infection · doi:10.1007/s15010-012-0273-2 · Cited by 29
Clinical characteristics and risk factors for complications of candidaemia in adults: Focus on endophthalmitis, endocarditis, and osteoarticular infections
Shin, S. U., Yu, Y. H., Kim, S. S., Oh, T. H., Kim, S. E., Kim, U. J., Kang, S., Jang, H., Park, K., & Jung, S. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.01.049 · Cited by 28
Outcomes, Impact on Management, and Costs of Fungal Eye Disease Consults in a Tertiary Care Setting
Ghodasra, D. H., Eftekhari, K., Shah, A. R., & VanderBeek, B. L. (2014) · Ophthalmology · doi:10.1016/j.ophtha.2014.06.042 · Cited by 28
Incidence and Risk Factors of Ocular Infection Caused by Staphylococcus aureus Bacteremia
Jung, J., Lee, J., Yu, S. N., Kim, Y. K., Lee, J. Y., Sung, H., Kim, M., Kim, S., Lee, S., Choi, S., et al. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02651-15 · Cited by 28
No evidence of increased ocular involvement in candidemic patients initially treated with echinocandins
Muñóz, P., Vena, A., Padilla, B., Valerio, M., Sánchez, M. I. T., Puig‐Asensio, M., Fortün, J., Fernández‐Ruiz, M., Merino, P., Losa, J. E., et al. (2017) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2017.02.014 · Cited by 28
Duration of treatment for candidemia and risk for late-onset ocular candidiasis
Blennow, O., Tallstedt, L., Hedquist, B., & Gårdlund, B. (2012) · Infection · doi:10.1007/s15010-012-0369-8 · Cited by 27
Incidence and Clinical Predictors of Ocular Candidiasis in Patients withCandidaFungemia
Khalid, A., Clough, L. A., Symons, R. C. A., Mahnken, J. D., Dong, L., & Eid, A. J. (2014) · Interdisciplinary Perspectives on Infectious Diseases · doi:10.1155/2014/650235 · Cited by 27
Endogenous Candida endophthalmitis: Who is really at risk?
Seidelman, J., Fleece, M., Bloom, A., Lydon, E., Yang, W., Arnold, C., Weber, D. J., & Okeke, N. L. (2021) · Journal of Infection · doi:10.1016/j.jinf.2020.12.032 · Cited by 26
Ocular Involvement in Hospitalized Patients with Candidemia: Analysis at a Boston Tertiary Care Center
Huynh, N., Chang, H.-Y. P., & Borboli-Gerogiannis, S. (2012) · Ocular Immunology and Inflammation · doi:10.3109/09273948.2011.646383 · Cited by 26
Differences in Ocular Complications Between Candida albicans and Non-albicans Candida Infection Analyzed by Epidemiology and a Mouse Ocular Candidiasis Model
Abe, M., Kinjo, Y., Ueno, K., Takatsuka, S., Nakamura, S., Ogura, S., Kimura, M., Araoka, H., Sadamoto, S., Shinozaki, M., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02477 · Cited by 24
Invasive Candidiasis
Schroeder, J. A., Wilson, C. M., & Pappas, P. G. (2024) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2024.11.007 · Cited by 26
Risk Factors and Clinical Characteristics of Patients with Ocular Candidiasis
Sakamoto, T., Gotoh, K., Hashimoto, K., Tanamachi, C., & Watanabe, H. (2022) · Journal of Fungi · doi:10.3390/jof8050497 · Cited by 21
Posaconazole nanocrystals dry powder inhalers for the local treatment of invasive pulmonary aspergillosis
Li, X., Wang, Q., Huang, J., Xiao, Y., Zhang, X., Fan, X., Fang, Z., Wang, G., Qiu, Z., Luo, D., et al. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124938 · Cited by 20
Screening for Ocular Candidiasis Among Patients With Candidemia: Is It Time to Change Practice?
O’Donnell, M., Eller, A. W., Waxman, E. L., Clancy, C. J., & Nguyen, M. H. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciac233 · Cited by 20
Systemic Candida albicans Infection in Mice Causes Endogenous Endophthalmitis via Breaching the Outer Blood-Retinal Barrier
Singh, S., Singh, S., & Kumar, A. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01658-22 · Cited by 20
Fundoscopy screening for intraocular candida in patients with positive blood cultures—is it justified?
El-Abiary, M., Jones, B. L., Williams, G. J., & Lockington, D. (2018) · Eye · doi:10.1038/s41433-018-0160-x · Cited by 20
Endogenous endophthalmitis and other ocular manifestations of injection drug use
Luong, P. M., Tsui, E. Y. K., Batra, N. N., & Zegans, M. E. (2019) · Current Opinion in Ophthalmology · doi:10.1097/icu.0000000000000606 · Cited by 20
Mind the gaps: challenges in the clinical management of invasive candidiasis in critically ill patients
Pietrobom, P. M. P., & Colombo, A. L. (2020) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000684 · Cited by 20
Risk Factors for Endogenous Endophthalmitis in Hospitalized Patients with Candida Fungemia
Uppuluri, A., Zarbin, M. A., Budoff, G., & Bhagat, N. (2020) · Ophthalmology Retina · doi:10.1016/j.oret.2020.10.007 · Cited by 20
The Incidence of Ocular Complications in Candidemic Patients and Implications for the Practice of Routine Eye Exams
Hillenbrand, M., Mendy, A., Patel, K., Wilkinson, R., Liao, S., Robertson, J., & Apewokin, S. K. (2022) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofac045 · Cited by 19
Prevalence and factors predictive of intraocular fungal infection in patients with fungemia at an academic urban tertiary care center
Brar, V. S., Geraymovych, E., Conduff, J., Braich, P. S., & Leffler, C. T. (2015) · Clinical ophthalmology · doi:10.2147/opth.s91540 · Cited by 19
Investigation of a new horizon antifungal activity with enhancing the antimicrobial efficacy of ciprofloxacin and its binary mixture via their encapsulation in nanoassemblies: in vitro and in vivo evaluation
Taleb, S. A. A., Darwish, A. B., Abood, A., & Mohamed, A. M. (2019) · Drug Development Research · doi:10.1002/ddr.21632 · Cited by 17
Efficacy of T-2307, a novel arylamidine, against ocular complications of disseminated candidiasis in mice
Abe, M., Nakamura, S., Kinjo, Y., Masuyama, Y., Mitsuyama, J., Kaku, M., & Miyazaki, Y. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz020 · Cited by 17
Nosocomial Candida parapsilosis candidaemia: risk factors, antifungal susceptibility and outcome
Hirai, Y., Asahata, S., Ainoda, Y., Goto, A., Fujita, T., & Totsuka, K. (2014) · Journal of Hospital Infection · doi:10.1016/j.jhin.2014.02.006 · Cited by 17
Candidemia y candidiasis invasora en el adulto. Formas clínicas y tratamiento
Cervera, C. (2012) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/j.eimc.2012.02.003 · Cited by 35
Factors associated with the development of ocular candidiasis and ocular prognosis with echinocandin therapy for candidemia
Sakai, D., Matsumiya, W., Kusuhara, S., & Nakamura, M. (2021) · Journal of Ophthalmic Inflammation and Infection · doi:10.1186/s12348-021-00248-0 · Cited by 17
Candidiasis sistémica en pacientes críticos, factores predictores de riesgo
Universidad Pedagógica y Tecnológica de Colombia, E. D. M. T., Lazo, V., Hernández, G., Universidad Pedagógica y Tecnológica de Colombia, E. D. M. T., Méndez, Y. R., & Universidad Pedagógica y Tecnológica de Colombia, E. D. M. T. (2018) · Horizonte Médico (Lima) · doi:10.24265/horizmed.2018.v18n1.11 · Cited by 19
Épico project. Development of educational recommendations using the DELPHI technique on invasive candidiasis in non-neutropenic critically ill adult patients
Zaragoza, R., Llinares, P., Maseda, E., Ferrer, R., & Rodríguez, A. H. (2013) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2013.05.006 · Cited by 14
CLINICAL UTILITY OF BETA-D-GLUCAN TESTING FOR ENDOGENOUS FUNGAL CHORIORETINITIS OR ENDOPHTHALMITIS
Ammar, M. J., Carroll, R. M., Kolomeyer, A. M., Ying, G., Whitehead, G., Brucker, A. J., & Kim, B. J. (2020) · Retina · doi:10.1097/iae.0000000000002861 · Cited by 14
Pediatric uveitis: Role of the pediatrician
Shivpuri, A., Turtsevich, I. Z., Solebo, A. L., & Compeyrot‐Lacassagne, S. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.874711 · Cited by 13
Candida Biofilm Eye Infection: Main Aspects and Advance in Novel Agents as Potential Source of Treatment
Petrillo, F., Sinoca, M., Fea, A. M., Galdiero, M., Maione, A., Galdiero, E., Guida, M., & Reibaldi, M. (2023) · Antibiotics · doi:10.3390/antibiotics12081277 · Cited by 13
Evaluation of Susceptibility and Innate Immune Response in C57BL/6 and BALB/c Mice During Candida albicans Endophthalmitis
Rottmann, B. G., Singh, P. K., Singh, S., Revankar, S. G., Chandrasekar, P. H., & Kumar, A. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.11.31 · Cited by 13
Endophthalmitis
Neß, T. (2018) · Der Ophthalmologe · doi:10.1007/s00347-018-0729-6 · Cited by 13
Clinical Features and Outcomes of Persistent Candidemia Caused by Candida albicans versus Non-albicans Candida Species: A Focus on Antifungal Resistance and Follow-Up Blood Cultures
Kitaya, S., Kanamori, H., Katori, Y., & Tokuda, K. (2023) · Microorganisms · doi:10.3390/microorganisms11040928 · Cited by 12
Candida Species
Edwards, J. E. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00258-7 · Cited by 12
Outcomes and Clinical Features Predictive of Fungal Endophthalmitis
Priluck, A., Huang, P., & Breazzano, M. P. (2023) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2023.02.011 · Cited by 11
Study of ocular candidiasis during nine-year period
Tanaka, H., Ishida, K., Yamada, W., Nishida, T., Mochizuki, K., & Kawakami, H. (2016) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2015.12.001 · Cited by 11
The Incidence of Ocular Candidiasis and Evaluation of Routine Ophthalmic Examination in Critically Ill Patients with Candidaemia
Gluck, S., Headdon, W., Tang, D. W. S., Bastian, I., Goggin, M., & Deane, A. M. (2015) · Anaesthesia and Intensive Care · doi:10.1177/0310057x1504300605 · Cited by 11
Effect of first-line antifungal treatment on ocular complication risk in Candida or yeast blood stream infection
Hautala, N. M., Köykkä, H., Siiskonen, M., Saari, J., Kauranen, J., & Hautala, T. (2021) · BMJ Open Ophthalmology · doi:10.1136/bmjophth-2021-000837 · Cited by 10
Do Patients With Candidemia Need an Ophthalmologic Examination?
Lehman, A. C., Tessier, K., Sattarova, V., Montezuma, S. R., Kline, S., & Erayil, S. E. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofae663 · Cited by 9
AIDS-related Cryptococcus neoformans choroiditis
Canfield, G. S., Reingold, S. B., Ho, A. P., Thor, A. D., Pecen, P. E., DeSanto, K., Chastain, D. B., Franco‐Paredes, C., Castillo‐Mancilla, J., & Henao‐Martínez, A. F. (2020) · IDCases · doi:10.1016/j.idcr.2020.e00931 · Cited by 9
Candida Endophthalmitis Treated Successfully With Isavuconazole: A Case Report
Sng, E. C. Y., Tan, A. L., Zhou, P. Y., Tan, T. J., Waduthantri, S., Chee, S.-P., & Tan, B. H. (2021) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofab516 · Cited by 9
Ocular Involvement in Patients with Fungemia in an Urban Tertiary Care Center
Price, K. W., Tsui, E. Y. K., BARBAZETTO, I. A., & Park, L. (2017) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2017.1381271 · Cited by 9
Tratamiento antifúngico individualizado en el paciente crítico con infección fúngica invasora
Zaragoza, R., Maseda, E., & Pemán, J. (2021) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2021.04.006 · Cited by 9
Endogenous Fungal Endophthalmitis in a Patient Admitted to Intensive Care and Treated with Systemic Steroid for COVID-19
Kaderli, S. T., Karalezlı, A., Çitil, B. E., & Saatçi, A. O. (2022) · Turkish Journal of Ophthalmology · doi:10.4274/tjo.galenos.2022.04324 · Cited by 8
Candida guilliermondii-induced chorioretinitis in a patient with eating disorder
Tamura, A., Kawamoto, D., Minami, K., Yasuda, S., Tsujimoto, H., Tsuda, Y., Mizumoto, K., & Suzuki, H. (2020) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2020.11.005 · Cited by 8

Authors: Oude Lashof, A. M. L., Rothova, A., Sobel, J. D., Ruhnke, M., Pappas, P. G., Viscoli, C., Schlamm, H. T., Oborska, I. T., Rex, J. H., & Kullberg, B. J.
Affiliations: Wayne State University (US)
Humboldt-Universität zu Berlin (DE)
University of Alabama at Birmingham (US)
University of Genoa (IT)
Pfizer (United States) (US)
The University of Texas Health Science Center at Houston (US)
Radboud University Nijmegen (NL)
ORCID: Sobel, J. D.
Ruhnke, M.
Pappas, P. G.
Rex, J. H.
Kullberg, B. J.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2011-07-15
Volume: 53
Issue: 3
Pages: 262-268
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1093/cid/cir355
OpenAlex: W2119470586
Cited by: 218
References: 29
Citations by year: 2026: 7 · 2025: 14 · 2024: 10 · 2023: 16 · 2022: 18 · 2021: 20 · 2020: 15 · 2019: 19 · 2018: 17 · 2017: 15 · 2016: 16 · 2015: 12 · 2014: 16 · 2013: 10 · 2012: 12
FWCI: 8.41
Type: journal article
Language: en
Open access: green
cris.maastrichtuniversity.nl
Licence: other-oa
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, other-oa)
CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Infective Endocarditis Diagnosis and Management
Keywords: ocular candidiasis, candidemia, endophthalmitis, chorioretinitis, Candida, voriconazole, amphotericin B, fluconazole, antifungal therapy, non-neutropenic patients, treatment outcomes
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Amphotericin B, Antifungal Agents, Candida, Female, Humans, Male, Middle Aged, Endophthalmitis, Prospective Studies, Pyrimidines, Risk Factors, Triazoles, Fluconazole, Eye Infections, Fungal, Incidence, Young Adult, Candidemia, Voriconazole

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Ocular Manifestations of Candidemia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks