The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Evaluation of a Novel Point-of-Care Cryptococcal Antigen Test on Serum, Plasma, and Urine From Patients With HIV-Associated Cryptococcal Meningitis
Open accessAbstract
BACKGROUND: Many deaths from cryptococcal meningitis (CM) may be preventable through early diagnosis and treatment. An inexpensive point-of-care (POC) assay for use with urine or a drop of blood would facilitate early diagnosis of cryptococcal infection in resource-limited settings. We compared cryptococcal antigen (CRAG) concentrations in plasma, serum, and urine from patients with CM, using an antigen-capture assay for glucuronoxylomannan (GXM) and a novel POC dipstick test. METHODS: GXM concentrations were determined in paired serum, plasma, and urine from 62 patients with active or recent CM, using a quantitative sandwich enzyme-linked immunosorbent assay (ELISA). A dipstick lateral-flow assay developed using the same monoclonal antibodies for the sandwich ELISA was tested in parallel. Correlation coefficients were calculated using Spearman rank test. RESULTS: All patients had detectable GXM in serum, plasma, and urine using the quantitative ELISA. Comparison of paired serum and plasma showed identical results. There were strong correlations between GXM levels in serum/urine (r(s) = 0.86; P < .001) and plasma/urine (r(s) = 0.85; P < .001). Levels of GXM were 22-fold lower in urine than in serum/plasma. The dipstick test was positive in serum, plasma, and urine in 61 of 62 patients. Dipstick titers correlated strongly with ELISA. Correlations between the methods were 0.93 (P < .001) for serum, 0.94 (P < .001) for plasma, and 0.94 (P < .001) for urine. CONCLUSIONS: This novel dipstick test has the potential to markedly improve early diagnosis of CM in many settings, enabling testing of urine in patients presenting to health care facilities in which lumbar puncture, or even blood sampling, is not feasible.
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Requirements for high impact diagnostics in the developing world
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Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults
French, N., Gray, K., Watera, C., Nakiyingi, J., Lugada, E., Moore, M., Lalloo, D., Whitworth, J. A. G., & Gilks, C. F. (2002) · AIDS · doi:10.1097/00002030-200205030-00009 · Cited by 417
Jarvis, J. N., Lawn, S. D., Vogt, M., Bangani, N., Wood, R., & Harrison, T. S. (2009) · Clinical Infectious Diseases · doi:10.1086/597262 · Cited by 318
Self-citationKambugu, A., Meya, D. B., Rhein, J., O’Brien, M., Janoff, E. N., Ronald, A. R., Kamya, M. R., Mayanja‐Kizza, H., Sande, M. A., Bohjanen, P. R., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/587667 · Cited by 300
Corticosteroids for Bacterial Meningitis in Adults in Sub-Saharan Africa
Scarborough, M., Gordon, S. B., Whitty, C. J. M., French, N., Njalale, Y., Chitani, A., Peto, T. E. A., Lalloo, D. G., & Zijlstra, E. E. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065711 · Cited by 281
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Self-citationAdult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases
Jarvis, J. N., Meintjes, G., Williams, A., Brown, Y., Crede, T., & Harrison, T. S. (2010) · BMC Infectious Diseases · doi:10.1186/1471-2334-10-67 · Cited by 266
Self-citationComparison of commercial kits for detection of cryptococcal antigen
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Hidden Killers: Human Fungal Infections
Brown, G. D., Denning, D. W., Gow, N. A. R., Levitz, S. M., Netea, M. G., & White, T. C. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004404 · Cited by 4,284
Diagnostic point-of-care tests in resource-limited settings
Drain, P. K., Hyle, E. P., Noubary, F., Freedberg, K. A., Wilson, D., Bishai, W. R., Rodriguez, W., & Bassett, I. V. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70250-0 · Cited by 744
Maziarz, E. K., & Perfect, J. R. (2016) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.10.006 · Cited by 698
Cryptococcus: from environmental saprophyte to global pathogen
May, R. C., Stone, N. R. H., Wiesner, D. L., Bicanic, T., & Nielsen, K. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.6 · Cited by 541
Limper, A. H., Adenis, A., Le, T., & Harrison, T. S. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30303-1 · Cited by 472
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Metadata
- Authors
- Jarvis, J. N., Percival, A., Bauman, S., Pelfrey, J., Meintjes, G., Williams, G. N., Longley, N., Harrison, T. S., & Kozel, T. R.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-09-21
- Volume
- 53
- Issue
- 10
- Pages
- 1019-1023
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2121822883
- Cited by
- 295
- References
- 18
- FWCI
- 20.75
- Type
- journal article
- Language
- en
- Open access
- green
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