Cited by 1,331HIV-related health complications and treatmentsHIV/AIDS Research and InterventionsHIV Research and Treatment

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. Premature Age-Related Comorbidities Among HIV-Infected Persons Compared with the General Population.

Guaraldi, G., Orlando, G., Zona, S., Menozzi, M., Carli, F., Garlassi, E., Berti, A., Rossi, E., Roverato, A., Palella, F.·2011·Clinical Infectious Diseases

DOI 10.1093/cid/cir627

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Abstract

BACKGROUND: Human immunodeficiency virus (HIV)-infected patients may have a greater risk of noninfectious comorbidities (NICMs) compared with the general population. We assessed the prevalence and risk factors for NICMs in a large cohort of HIV-infected adults and compared these findings with data from matched control subjects. METHODS: We performed a case-control study involving antiretroviral therapy (ART)-experienced HIV-infected patients treated at Modena University, Italy, from 2002 through 2009. These patients were compared with age-, sex-, and race-matched adults (control subjects) from the general population included in the CINECA ARNO database. NICMs included cardiovascular disease, hypertension, diabetes mellitus, bone fractures, and renal failure. Polypathology (Pp) was defined as the concurrent presence of ≥2 NICMs. Logistic regression models were constructed to evaluate associated predictors of NICMs and Pp. RESULTS: There were 2854 patients and 8562 control subjects. The mean age was 46 years, and 37% were women. Individual NICM and Pp prevalences in each age stratum were higher among patients than among controls (all P <.001). Pp prevalence among patients aged 41-50 years was similar to that among controls aged 51-60 years (P value was not statistically significant); diabetes mellitus, cardiovascular disease, bone fractures, and renal failure were statistically independent after adjustment for sex, age, and hypertension. Logistic regression models showed that independent predictors of Pp in the overall cohort were (all P < .001) age (odds ratio [OR], 1.11), male sex (OR, 1.77), nadir CD4 cell count <200 cells/μL (OR, 4.46), and ART exposure (OR, 1.01). CONCLUSIONS: Specific age-related NICMs and Pp were more common among HIV-infected patients than in the general population. The prevalence of Pp in HIV-infected persons anticipated Pp prevalence observed in the general population among persons who were 10 years older, and HIV-specific cofactors (lower nadir CD4 cell count and more prolonged ART exposure) were identified as risk factors. These data support the need for earlier screening for NICMs in HIV-infected patients.

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Authors: Guaraldi, G., Orlando, G., Zona, S., Menozzi, M., Carli, F., Garlassi, E., Berti, A., Rossi, E., Roverato, A., & Palella, F.
Affiliations: University of Modena and Reggio Emilia (IT)
Cineca (IT)
University of Bologna (IT)
Northwestern University (US)
ORCID: Guaraldi, G.
Orlando, G.
Zona, S.
Menozzi, M.
Carli, F.
Rossi, E.
Roverato, A.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2011-10-13
Volume: 53
Issue: 11
Pages: 1120-1126
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1093/cid/cir627
OpenAlex: W2135397849
Cited by: 1,331
References: 31
Citations by year: 2026: 63 · 2025: 72 · 2024: 96 · 2023: 84 · 2022: 89 · 2021: 122 · 2020: 119 · 2019: 117 · 2018: 131 · 2017: 100 · 2016: 92 · 2015: 66 · 2014: 79 · 2013: 55 · 2012: 38
FWCI: 65.23
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion)
Padua Research Archive (University of Padova) (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords: HIV infection, age-related comorbidities, cardiovascular disease, hypertension, diabetes mellitus, bone fractures, renal failure, antiretroviral therapy, risk factors, comorbidity screening
MeSH terms: Adult, Age Factors, Cardiovascular Diseases, Diabetes Mellitus, Female, Humans, Hypertension, Italy, Male, Middle Aged, Risk Factors, HIV Infections, Comorbidity, Prevalence, Case-Control Studies, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Fractures, Bone, Renal Insufficiency

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. Premature Age-Related Comorbidities Among HIV-Infected Persons Compared with the General Population.

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