HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity.

Deeks, S. G; Phillips, A. N

doi:10.1136/bmj.a3172

Cited by 704HIV-related health complications and treatmentsHIV/AIDS drug development and treatmentHIV/AIDS Research and Interventions

HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity.

Deeks, S. G, Phillips, A. N·2009·BMJ

DOI 10.1136/bmj.a3172

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Abstract

#### Summary points More than 25 antiretroviral drugs from six therapeutic classes are now available for the management of HIV infection (box 1). Most patients who take medication achieve durable and perhaps lifelong viral suppression, so the classic AIDS related conditions are becoming less common. However, treated patients do not have completely restored health. Compared with people without HIV infection, patients with the infection who are treated with antiretrovirals have increased risk for several “non-AIDS” complications, many of which are commonly associated with ageing (box 2). This risk is particularly evident in patients whose CD4+ T cell counts are below normal during long term treatment, but it is also seen to some extent in those with higher CD4+ T cell counts. As a consequence of the changing spectrum of HIV associated disease, the medical management of HIV infection is evolving—a lower proportion of time is now spent managing drug resistance and short term toxicities and a higher proportion is spent managing these premature age associated complications. This review discusses the evidence that the major complications of “treated” HIV disease—including cardiovascular disease, malignancy, renal disease, …

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Authors: Deeks, S. G., & Phillips, A. N.
Affiliations: San Francisco General Hospital (US)
The Royal Free Hospital (GB)
Corresponding author: Deeks, S. G
ORCID: Phillips, A. N
Venue: BMJ
Publisher: BMJ
Published: 2009-01-26
Volume: 338
Issue: jan26 2
Pages: a3172-a3172
ISSN: 0007-1447 (ISSN-L)
0959-8138
1468-5833
DOI: 10.1136/bmj.a3172
OpenAlex: W2110559078
Cited by: 704
References: 25
Citations by year: 2026: 14 · 2025: 14 · 2024: 22 · 2023: 27 · 2022: 36 · 2021: 38 · 2020: 37 · 2019: 48 · 2018: 47 · 2017: 48 · 2016: 46 · 2015: 71 · 2014: 57 · 2013: 61 · 2012: 53
FWCI: 47.39
Type: journal article
Language: en
Open access: closed
Locations: BMJ (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords: HIV infection, antiretroviral therapy, aging, CD4 count, cardiovascular disease, HIV-associated malignancies, kidney disease, drug resistance, long-term viral suppression
MeSH terms: Age Factors, Cardiovascular Diseases, Health Status, Humans, Kidney Diseases, Liver Diseases, Neoplasms, Risk Factors, HIV Infections, Treatment Outcome, CD4 Lymphocyte Count, Anti-HIV Agents

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HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity.

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