The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Systematic Review and Meta-analysis of the Association Between Giardia lamblia and Endemic Pediatric Diarrhea in Developing Countries
Open accessAbstract
We performed a systematic literature review and meta-analysis examining the association between diarrhea in young children in nonindustrialized settings and Giardia lamblia infection. Eligible were case/control and longitudinal studies that defined the outcome as acute or persistent (>14 days) diarrhea, adjusted for confounders and lasting for at least 1 year. Data on G. lamblia detection (mainly in stools) from diarrhea patients and controls without diarrhea were abstracted. Random effects model meta-analysis obtained pooled odds ratios (ORs) and 95% confidence intervals (CIs). Twelve nonindustrialized-setting acute pediatric diarrhea studies met the meta-analysis inclusion criteria. Random-effects model meta-analysis of combined results (9774 acute diarrhea cases and 8766 controls) yielded a pooled OR of 0.60 (95% CI, .38-.94; P = .03), indicating that G. lamblia was not associated with acute diarrhea. However, limited data suggest that initial Giardia infections in early infancy may be positively associated with diarrhea. Meta-analysis of 5 persistent diarrhea studies showed a pooled OR of 3.18 (95% CI, 1.50-6.76; P < .001), positively linking Giardia with that syndrome. The well-powered Global Enteric Multicenter Study (GEMS) is prospectively addressing the association between G. lamblia infection and diarrhea in children in developing countries.
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Funnel plots for detecting bias in meta-analysis
Sterne, J. A. C., & Egger, M. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(01)00377-8 · Cited by 3,779
Incidence and etiology of infantile diarrhea and major routes of transmission in Huascar, Peru
BLACK, R. E., LOPEZ DE ROMA, G., BROWN, K. H., BRAVO, N., GRADOS BAZALAR, O., & CREED KANASHTRO, H. (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115193 · Cited by 269 · cited 2×
“Black [116] Peru 153 newborns followed from birth ≥1 d with liquid stools totaling 6 for infants <1 mo, 5 for infants aged 1 mo & 4 for older infants.”
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Metadata
- Authors
- Muhsen, K., & Levine, M. M.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-12-15
- Volume
- 55
- Issue
- suppl_4
- Pages
- S271-S293
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W1968710639
- Cited by
- 208
- References
- 2
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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