Failure of High-Dose Daptomycin for Bacteremia Caused by Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions
Open accessAbstract
High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 µg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium strains with minimum inhibitory concentrations >2 µg/mL.
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These changes were sufficient to abolish the in vitro bactericidal activity of DAP and were associated with a clinical failure in a neutropenic patient with VRE bacteremia.
“More importantly, these changes were sufficient to abolish the in vitro bactericidal activity of DAP and were associated with a clinical failure in a neutropenic patient with VRE bacteremia (92).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [92]
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Cites
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MULTIDRUG-RESISTANT ENTEROCOCCUS FAECIUM MENINGITIS IN A TODDLER
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- Diaz L, Tran TT, Munita JM, et al. Whole genome analyses of Entero- coccus faecium with diverse daptomycin minimal inhibitory concentra- tions. Antimicrob Agents Chemother 2014; 58:4527-34.
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- Authors
- Munita, J. M., Mishra, N. N., Alvarez, D., Tran, T. T., Diaz, L., Panesso, D., Reyes, J., Murray, B. E., Adachi, J. A., Bayer, A. S., & Arias, C. A.
- Affiliations
- Universidad del Desarrollo (CL)
- University of California, Los Angeles (US)
- Universidad El Bosque (CO)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Munita, Jose M.
- ORCID
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-08-08
- Volume
- 59
- Issue
- 9
- Pages
- 1277-1280
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- PMC
- PMC4271039
- OpenAlex
- W2097259039
- Cited by
- 70
- References
- 13
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 12 · 2014: 2
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Infectious Diseases (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Repositorio Institucional Universidad El Bosque (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01-AI-39108, R01AI093749, K08AI113317, R01AI039108, R01AI047923)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- daptomycin, Enterococcus faecium, bacteremia, daptomycin resistance, high-dose daptomycin, bloodstream infection, antimicrobial resistance selection, minimum inhibitory concentration, monotherapy
- MeSH terms
- Adult, Anti-Bacterial Agents, Humans, Male, Microbial Sensitivity Tests, Bacteremia, Gram-Positive Bacterial Infections, Enterococcus faecium, Treatment Failure, Daptomycin, Fatal Outcome, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Young Adult, Chemotherapy-Induced Febrile Neutropenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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